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Study · Animal study (in vivo) · rat · 2018

9 results

Activation of AMPK alleviates cardiopulmonary bypass-induced cardiac injury via ameliorating acute cardiac glucose metabolic disorder.

Wang Z, Cao Y, Yin Q, Han Y, Wang Y, Sun G, Zhu H, Xu M, Gu C

Cardiovascular therapeutics1 Dec 2018Cited by 8 (Europe PMC)

PMID30632675 (opens in a new tab)DOI10.1111/1755-5922.12482 (opens in a new tab)PepBankPUB-30632675
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats undergoing cardiopulmonary bypass, AICAR pretreatment activated AMPK.

    In plain wordsIn rats, AICAR increased AMPK activation compared with bypass without AICAR pretreatment.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAMPK activation
    Study

    ratn: not reported in source

    Cardiopulmonary bypass
    Comparator
    Cardiopulmonary bypass without AICAR pretreatment
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, pretreatment of AMPK agonist 5-aminoimidazole-4-carboxamide1-β-D-ribofuranoside (AICAR) at the beginning of CPB activated AMPK, enhanced phosphorylation of Akt substrate 160 (AS160), and increased myocardial membrane content of GLUT4.
    1 context sentence
    Summary · context
    In this study, a rat model of cardiopulmonary bypass (CPB) was applied to investigate the role of Adenosine 5'-monophosphate-activated protein kinase (AMPK) in modulating myocardial glucose metabolic-induced cardiac injuries after cardiac surgery.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats undergoing cardiopulmonary bypass, AICAR pretreatment enhanced AS160 phosphorylation.

    In plain wordsIn rats, AICAR increased AS160 phosphorylation compared with bypass without AICAR pretreatment.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAS160 phosphorylation
    Study

    ratn: not reported in source

    Cardiopulmonary bypass
    Comparator
    Cardiopulmonary bypass without AICAR pretreatment
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, pretreatment of AMPK agonist 5-aminoimidazole-4-carboxamide1-β-D-ribofuranoside (AICAR) at the beginning of CPB activated AMPK, enhanced phosphorylation of Akt substrate 160 (AS160), and increased myocardial membrane content of GLUT4.
    1 context sentence
    Summary · context
    In this study, a rat model of cardiopulmonary bypass (CPB) was applied to investigate the role of Adenosine 5'-monophosphate-activated protein kinase (AMPK) in modulating myocardial glucose metabolic-induced cardiac injuries after cardiac surgery.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats undergoing cardiopulmonary bypass, AICAR pretreatment increased myocardial membrane GLUT4 content.

    In plain wordsIn rats, AICAR increased heart membrane GLUT4 compared with bypass without AICAR pretreatment.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseMyocardial membrane GLUT4
    Study

    ratn: not reported in source

    Cardiopulmonary bypass
    Comparator
    Cardiopulmonary bypass without AICAR pretreatment
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, pretreatment of AMPK agonist 5-aminoimidazole-4-carboxamide1-β-D-ribofuranoside (AICAR) at the beginning of CPB activated AMPK, enhanced phosphorylation of Akt substrate 160 (AS160), and increased myocardial membrane content of GLUT4.
    1 context sentence
    Summary · context
    In this study, a rat model of cardiopulmonary bypass (CPB) was applied to investigate the role of Adenosine 5'-monophosphate-activated protein kinase (AMPK) in modulating myocardial glucose metabolic-induced cardiac injuries after cardiac surgery.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats undergoing cardiopulmonary bypass, AICAR pretreatment improved myocardial glucose uptake.

    In plain wordsIn rats, AICAR improved heart glucose uptake compared with bypass without AICAR pretreatment.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseMyocardial glucose uptake
    Study

    ratn: not reported in source

    Cardiopulmonary bypass
    Comparator
    Cardiopulmonary bypass without AICAR pretreatment
    Outcome group
    Glycemic control · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Meanwhile, improved myocardial glucose uptake and more importantly alleviated cardiac injury were also observed after CPB pretreated with AICAR.
    1 context sentence
    Summary · context
    In this study, a rat model of cardiopulmonary bypass (CPB) was applied to investigate the role of Adenosine 5'-monophosphate-activated protein kinase (AMPK) in modulating myocardial glucose metabolic-induced cardiac injuries after cardiac surgery.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats undergoing cardiopulmonary bypass, AICAR pretreatment alleviated cardiac injury.

    In plain wordsIn rats, AICAR reduced heart injury compared with bypass without AICAR pretreatment.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCardiac injury
    Study

    ratn: not reported in source

    Cardiopulmonary bypass
    Comparator
    Cardiopulmonary bypass without AICAR pretreatment
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Meanwhile, improved myocardial glucose uptake and more importantly alleviated cardiac injury were also observed after CPB pretreated with AICAR.
    1 context sentence
    Summary · context
    In this study, a rat model of cardiopulmonary bypass (CPB) was applied to investigate the role of Adenosine 5'-monophosphate-activated protein kinase (AMPK) in modulating myocardial glucose metabolic-induced cardiac injuries after cardiac surgery.

Studies that did not test the peptide alone4

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 06AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In rats after bypass, mutant AS160 abolished AICAR benefit on cardiac glucose uptake.

    In plain wordsIn rats, mutant AS160 reduced heart glucose uptake compared with AICAR without the mutant.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseGlucose uptake with AS160 mutant
    Study

    ratn: not reported in source

    Cardiopulmonary bypass
    Comparator
    AICAR without AS160-4P
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    Moreover, the application of a mutant form of AS160 (AS160-4P) abolished the beneficial effect of AICAR, as evidenced by impaired cardiac glucose uptake, reduced myocardial membrane GLUT-4 translocation, increased cardiac injury markers, and deterioration of cardiac function after CPB.
    1 context sentence
    Summary · context
    In this study, a rat model of cardiopulmonary bypass (CPB) was applied to investigate the role of Adenosine 5'-monophosphate-activated protein kinase (AMPK) in modulating myocardial glucose metabolic-induced cardiac injuries after cardiac surgery.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 07AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In rats after bypass, mutant AS160 reduced myocardial membrane GLUT4 translocation despite AICAR.

    In plain wordsIn rats, mutant AS160 reduced heart membrane GLUT4 movement compared with AICAR without the mutant.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseMembrane GLUT4 translocation with AS160 mutant
    Study

    ratn: not reported in source

    Cardiopulmonary bypass
    Comparator
    AICAR without AS160-4P
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    Moreover, the application of a mutant form of AS160 (AS160-4P) abolished the beneficial effect of AICAR, as evidenced by impaired cardiac glucose uptake, reduced myocardial membrane GLUT-4 translocation, increased cardiac injury markers, and deterioration of cardiac function after CPB.
    1 context sentence
    Summary · context
    In this study, a rat model of cardiopulmonary bypass (CPB) was applied to investigate the role of Adenosine 5'-monophosphate-activated protein kinase (AMPK) in modulating myocardial glucose metabolic-induced cardiac injuries after cardiac surgery.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  3. 08AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In rats after bypass, mutant AS160 increased cardiac injury markers despite AICAR.

    In plain wordsIn rats, mutant AS160 increased heart injury markers compared with AICAR without the mutant.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseCardiac injury markers with AS160 mutant
    Study

    ratn: not reported in source

    Cardiopulmonary bypass
    Comparator
    AICAR without AS160-4P
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    Moreover, the application of a mutant form of AS160 (AS160-4P) abolished the beneficial effect of AICAR, as evidenced by impaired cardiac glucose uptake, reduced myocardial membrane GLUT-4 translocation, increased cardiac injury markers, and deterioration of cardiac function after CPB.
    1 context sentence
    Summary · context
    In this study, a rat model of cardiopulmonary bypass (CPB) was applied to investigate the role of Adenosine 5'-monophosphate-activated protein kinase (AMPK) in modulating myocardial glucose metabolic-induced cardiac injuries after cardiac surgery.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  4. 09AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In rats after bypass, mutant AS160 worsened cardiac function despite AICAR.

    In plain wordsIn rats, mutant AS160 worsened heart function compared with AICAR without the mutant.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCardiac function with AS160 mutant
    Study

    ratn: not reported in source

    Cardiopulmonary bypass
    Comparator
    AICAR without AS160-4P
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    Moreover, the application of a mutant form of AS160 (AS160-4P) abolished the beneficial effect of AICAR, as evidenced by impaired cardiac glucose uptake, reduced myocardial membrane GLUT-4 translocation, increased cardiac injury markers, and deterioration of cardiac function after CPB.
    1 context sentence
    Summary · context
    In this study, a rat model of cardiopulmonary bypass (CPB) was applied to investigate the role of Adenosine 5'-monophosphate-activated protein kinase (AMPK) in modulating myocardial glucose metabolic-induced cardiac injuries after cardiac surgery.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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