Exogenous H₂S alleviates senescence of glomerular mesangial cells through up-regulating mitophagy by activation of AMPK-ULK1-PINK1-parkin pathway in mice.

E Y, Lin Y, Yan G, Yang J, Jiao L, Wu R, Yan Q, Chen Y, Chen Y, Yan X, Li H

Biochimica et biophysica acta. Molecular cell research18 Aug 2023Cited by 16 (Europe PMC)

PMID37597773DOI10.1016/j.bbamcr.2023.119568PepBankPUB-37597773

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study27

27 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In D-gal-treated mice, AICAR reversed reduced renal function similarly to NaHS compared with D-gal alone.
In plain wordsIn mice, AICAR improved kidney function similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
IncreaseRenal function
Study
mousen: not reported in source
D-galactose-treated mice
Comparator
D-gal group
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
Here, results of experiments in vivo and in vitro showed that compared with control group, the renal function of mice and GMCs viability were decreased in D-gal (D-galactose) group,
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777301
02LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed reduced viability similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR improved viability similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
IncreaseGMC viability
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Cell viability and death · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
Here, results of experiments in vivo and in vitro showed that compared with control group, the renal function of mice and GMCs viability were decreased in D-gal (D-galactose) group,
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777302
03LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed elevated SA-β-gal activity similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR reduced SA-β-gal activity similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
DecreaseSA-β-gal activity
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Aging markers · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
while the activity of SA-β-gal and p21 expression were increased,
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777303
04LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed increased p21 expression similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR reduced p21 expression similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
Decreasep21 expression
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Aging markers · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
while the activity of SA-β-gal and p21 expression were increased,
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777304
05LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed reduced Cyclin D1 expression similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR increased Cyclin D1 expression similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
IncreaseCyclin D1 expression
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Aging markers · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
Cyclin D1 and Klotho expressions were decreased;
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777305
06LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed reduced Klotho expression similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR increased Klotho expression similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
IncreaseKlotho expression
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Aging markers · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
Cyclin D1 and Klotho expressions were decreased;
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777306
07LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed reduced H2S content similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR increased hydrogen sulfide content similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
IncreaseH2S content
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Receptor activity and mechanism · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
H₂S content and CSE expression were lower;
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777307
08LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed reduced CSE expression similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR increased CSE expression similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
IncreaseCSE expression
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Receptor activity and mechanism · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
H₂S content and CSE expression were lower;
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777308
09LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed increased ROS content similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR reduced reactive oxygen species similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
DecreaseROS content
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Oxidative stress · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
ROS and MDA contents and mitochondrial permeability transition pore (mPTP) opening were risedose;
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777309
10LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed increased MDA content similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR reduced MDA content similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
DecreaseMDA content
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Oxidative stress · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
ROS and MDA contents and mitochondrial permeability transition pore (mPTP) opening were risedose;
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777310
11LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed increased mPTP opening similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR reduced mitochondrial pore opening similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
DecreaseMitochondrial permeability transition pore opening
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Mitochondrial function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
ROS and MDA contents and mitochondrial permeability transition pore (mPTP) opening were risedose;
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777311
12LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed reduced ATP production similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR increased ATP production similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
IncreaseATP production
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Mitochondrial function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
ATP production and mitochondrial membrane potential (Δψm) were reduced;
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777312
13LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed reduced mitochondrial membrane potential similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR increased mitochondrial membrane potential similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
IncreaseMitochondrial membrane potential
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Mitochondrial function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
ATP production and mitochondrial membrane potential (Δψm) were reduced;
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777313
14LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed increased apoptosis similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR reduced apoptosis similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
DecreaseApoptotic rate
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Cell viability and death · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
Apoptotic rate, the expression of Cleaved caspase-9 and -3, Cyt c, p62 and Drp1 were enhanced
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777314
15LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed elevated cleaved caspase-9 expression similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR reduced cleaved caspase-9 expression similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
DecreaseCleaved caspase-9 expression
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Cell viability and death · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
Apoptotic rate, the expression of Cleaved caspase-9 and -3, Cyt c, p62 and Drp1 were enhanced
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777315
16LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed elevated cleaved caspase-3 expression similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR reduced cleaved caspase-3 expression similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
DecreaseCleaved caspase-3 expression
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Cell viability and death · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
Apoptotic rate, the expression of Cleaved caspase-9 and -3, Cyt c, p62 and Drp1 were enhanced
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777316
17LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed elevated Cyt c expression similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR reduced cytochrome c expression similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
DecreaseCytochrome c expression
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Cell viability and death · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
Apoptotic rate, the expression of Cleaved caspase-9 and -3, Cyt c, p62 and Drp1 were enhanced
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777317
18LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed elevated p62 expression similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR reduced p62 expression similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
Decreasep62 expression
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Mitochondrial function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
Apoptotic rate, the expression of Cleaved caspase-9 and -3, Cyt c, p62 and Drp1 were enhanced
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777318
19LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed elevated Drp1 expression similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR reduced Drp1 expression similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
DecreaseDrp1 expression
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Mitochondrial function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
Apoptotic rate, the expression of Cleaved caspase-9 and -3, Cyt c, p62 and Drp1 were enhanced
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777319
20LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed reduced Bcl-2 expression similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR increased Bcl-2 expression similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
IncreaseBcl-2 expression
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Cell viability and death · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
and the expression of Bcl-2, Mfn2, Beclin-1, LC3 II/I, PINK1 and parkin were decreased.
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777320
21LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed reduced Mfn2 expression similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR increased Mfn2 expression similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
IncreaseMfn2 expression
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Mitochondrial function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
and the expression of Bcl-2, Mfn2, Beclin-1, LC3 II/I, PINK1 and parkin were decreased.
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777321
22LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed reduced Beclin-1 expression similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR increased Beclin-1 expression similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
IncreaseBeclin-1 expression
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Mitochondrial function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
and the expression of Bcl-2, Mfn2, Beclin-1, LC3 II/I, PINK1 and parkin were decreased.
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777322
23LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed reduced LC3 II/I expression similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR increased LC3 II/I expression similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
IncreaseLC3 II/I expression
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Mitochondrial function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
and the expression of Bcl-2, Mfn2, Beclin-1, LC3 II/I, PINK1 and parkin were decreased.
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777323
24LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed reduced PINK1 expression similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR increased PINK1 expression similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
IncreasePINK1 expression
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Mitochondrial function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
and the expression of Bcl-2, Mfn2, Beclin-1, LC3 II/I, PINK1 and parkin were decreased.
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777324
25LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed reduced parkin expression similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR increased parkin expression similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
IncreaseParkin expression
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Mitochondrial function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
and the expression of Bcl-2, Mfn2, Beclin-1, LC3 II/I, PINK1 and parkin were decreased.
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777325
26LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed reduced phospho-AMPK/AMPK similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR increased the phospho-AMPK/AMPK ratio similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
IncreasePhospho-AMPK/AMPK
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Receptor activity and mechanism · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
In addition, phospho-AMPK/AMPK and phospho-ULK1/ULK1 were also decreased significantly.
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777326
27LabIn vitro (cells)Mechanism
In D-gal-treated GMCs, AICAR reversed reduced phospho-ULK1/ULK1 similarly to NaHS compared with D-gal alone.
In plain wordsIn cells, AICAR increased the phospho-ULK1/ULK1 ratio similarly to NaHS compared with D-gal alone.
Peptide
AICAR (acadesine)
Outcome
IncreasePhospho-ULK1/ULK1
Study
mousen: not reported in source
D-galactose-treated glomerular mesangial cells
Comparator
D-gal group
Outcome group
Receptor activity and mechanism · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The reverse effects of NaHS were similar to that of AICAR (an AMPK agonist) and kinetin (a PINK1 agonist), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
In addition, phospho-AMPK/AMPK and phospho-ULK1/ULK1 were also decreased significantly.
Summary · context
Compared with the D-gal group, the changes of above indexes were reversed in the D-gal + NaHS (Sodium hydrosulfide, an exogenous H₂S donor) group.
Report a problemFND-3759777327

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

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Terms as the source lists them.

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