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Study · Animal study (in vivo) · rat · 2020

9 results

Whether AICAR in Pregnancy or Lactation Prevents Hypertension Programmed by High Saturated Fat Diet: A Pilot Study.

Tsai WL, Hsu CN, Tain YL

Nutrients11 Feb 2020Cited by 19 (Europe PMC)

PMID32053935 (opens in a new tab)PMCIDPMC7071394 (opens in a new tab)DOI10.3390/nu12020448 (opens in a new tab)PepBankPUB-32053935
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Summary

High consumption of saturated fats links to the development of hypertension. AMP-activated protein kinase (AMPK), a nutrient-sensing signal, is involved in the pathogenesis of hypertension. We examined whether early intervention with a direct AMPK activator 5-aminoimidazole-4-carboxamide riboside (AICAR) during pregnancy or lactation can protect adult male offspring against hypertension programmed by high saturated fat consumption via regulation of nutrient sensing signals, nitric oxide (NO) pathway, and oxidative stress. Pregnant Sprague-Dawley rats received regular chow or high saturated fat diet (HFD) throughout pregnancy and lactation. AICAR treatment was introduced by intraperitoneal injection at 50 mg/kg twice a day for 3 weeks throughout the pregnancy period (AICAR/P) or lactation period (AICAR/L). Male offspring (n = 7-8/group) were assigned to five groups: control, HFD, AICAR/P, HFD + AICAR/L, and HFD + AICAR/P. Male offspring were killed at 16 weeks of age. HFD caused hypertension and obesity in male adult offspring, which could be prevented by AICAR therapy used either during pregnancy or lactation. As a result, we demonstrated that HFD downregulated AMPK/SIRT1/PGC-1α pathway in offspring kidneys. In contrast, AICAR therapy in pregnancy and, to a greater extent, in lactation activated AMPK signaling pathway. The beneficial effects of AICAR therapy in pregnancy is related to restoration of NO pathway. While AICAR uses in pregnancy and lactation both diminished oxidative stress induced by HFD. Our results highlighted that pharmacological AMPK activation might be a promising strategy to prevent hypertension programmed by excessive consumption of high-fat food.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rat offspring, maternal AICAR during pregnancy prevented HFD-programmed hypertension.

    In plain wordsIn rats, maternal AICAR during pregnancy prevented high-fat-diet hypertension compared with HFD alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseHypertension after pregnancy treatment
    Study

    ratn: not reported in source

    male offspring of high saturated fat diet-fed Sprague-Dawley dams
    Comparator
    HFD without AICAR
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    50 mg/kg twice daily · intraperitoneal injection · 3 weeksAs given in this study (rat).

    Source sentences

    Summary
    HFD caused hypertension and obesity in male adult offspring, which could be prevented by AICAR therapy used either during pregnancy or lactation.
    1 context sentence
    Summary · context
    Pregnant Sprague-Dawley rats received regular chow or high saturated fat diet (HFD) throughout pregnancy and lactation. AICAR treatment was introduced by intraperitoneal injection at 50 mg/kg twice a day for 3 weeks throughout the pregnancy period (AICAR/P) or lactation period (AICAR/L).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male rat offspring, maternal AICAR during lactation prevented HFD-programmed hypertension.

    In plain wordsIn rats, maternal AICAR during lactation prevented high-fat-diet hypertension compared with HFD alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseHypertension after lactation treatment
    Study

    ratn: not reported in source

    male offspring of high saturated fat diet-fed Sprague-Dawley dams
    Comparator
    HFD without AICAR
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    50 mg/kg twice daily · intraperitoneal injection · 3 weeksAs given in this study (rat).

    Source sentences

    Summary
    HFD caused hypertension and obesity in male adult offspring, which could be prevented by AICAR therapy used either during pregnancy or lactation.
    1 context sentence
    Summary · context
    Pregnant Sprague-Dawley rats received regular chow or high saturated fat diet (HFD) throughout pregnancy and lactation. AICAR treatment was introduced by intraperitoneal injection at 50 mg/kg twice a day for 3 weeks throughout the pregnancy period (AICAR/P) or lactation period (AICAR/L).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male rat offspring, maternal AICAR during pregnancy prevented HFD-programmed obesity.

    In plain wordsIn rats, maternal AICAR during pregnancy prevented high-fat-diet obesity compared with HFD alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseObesity after pregnancy treatment
    Study

    ratn: not reported in source

    male offspring of high saturated fat diet-fed Sprague-Dawley dams
    Comparator
    HFD without AICAR
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    50 mg/kg twice daily · intraperitoneal injection · 3 weeksAs given in this study (rat).

    Source sentences

    Summary
    HFD caused hypertension and obesity in male adult offspring, which could be prevented by AICAR therapy used either during pregnancy or lactation.
    1 context sentence
    Summary · context
    Pregnant Sprague-Dawley rats received regular chow or high saturated fat diet (HFD) throughout pregnancy and lactation. AICAR treatment was introduced by intraperitoneal injection at 50 mg/kg twice a day for 3 weeks throughout the pregnancy period (AICAR/P) or lactation period (AICAR/L).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In male rat offspring, maternal AICAR during lactation prevented HFD-programmed obesity.

    In plain wordsIn rats, maternal AICAR during lactation prevented high-fat-diet obesity compared with HFD alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseObesity after lactation treatment
    Study

    ratn: not reported in source

    male offspring of high saturated fat diet-fed Sprague-Dawley dams
    Comparator
    HFD without AICAR
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    50 mg/kg twice daily · intraperitoneal injection · 3 weeksAs given in this study (rat).

    Source sentences

    Summary
    HFD caused hypertension and obesity in male adult offspring, which could be prevented by AICAR therapy used either during pregnancy or lactation.
    1 context sentence
    Summary · context
    Pregnant Sprague-Dawley rats received regular chow or high saturated fat diet (HFD) throughout pregnancy and lactation. AICAR treatment was introduced by intraperitoneal injection at 50 mg/kg twice a day for 3 weeks throughout the pregnancy period (AICAR/P) or lactation period (AICAR/L).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rat offspring, maternal AICAR during pregnancy activated AMPK signaling.

    In plain wordsIn rats, maternal AICAR during pregnancy increased AMPK signaling compared with HFD alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAMPK signaling after pregnancy treatment
    Study

    ratn: not reported in source

    male offspring of high saturated fat diet-fed Sprague-Dawley dams
    Comparator
    HFD without AICAR
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    50 mg/kg twice daily · intraperitoneal injection · 3 weeksAs given in this study (rat).

    Source sentences

    Summary
    In contrast, AICAR therapy in pregnancy and, to a greater extent, in lactation activated AMPK signaling pathway.
    1 context sentence
    Summary · context
    Pregnant Sprague-Dawley rats received regular chow or high saturated fat diet (HFD) throughout pregnancy and lactation. AICAR treatment was introduced by intraperitoneal injection at 50 mg/kg twice a day for 3 weeks throughout the pregnancy period (AICAR/P) or lactation period (AICAR/L).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rat offspring, maternal AICAR during lactation activated AMPK signaling more than treatment during pregnancy.

    In plain wordsIn rats, maternal AICAR during lactation increased AMPK signaling more than treatment during pregnancy.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAMPK signaling after lactation treatment
    Study

    ratn: not reported in source

    male offspring of high saturated fat diet-fed Sprague-Dawley dams
    Comparator
    AICAR during pregnancy
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    50 mg/kg twice daily · intraperitoneal injection · 3 weeksAs given in this study (rat).

    Source sentences

    Summary
    In contrast, AICAR therapy in pregnancy and, to a greater extent, in lactation activated AMPK signaling pathway.
    1 context sentence
    Summary · context
    Pregnant Sprague-Dawley rats received regular chow or high saturated fat diet (HFD) throughout pregnancy and lactation. AICAR treatment was introduced by intraperitoneal injection at 50 mg/kg twice a day for 3 weeks throughout the pregnancy period (AICAR/P) or lactation period (AICAR/L).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rat offspring, benefits of maternal AICAR during pregnancy were related to NO pathway restoration.

    In plain wordsIn rats, benefits of maternal AICAR during pregnancy accompanied restoration of the nitric oxide pathway.

    Peptide
    AICAR (acadesine)
    Outcome
    Not applicableNO pathway restoration
    Study

    ratn: not reported in source

    male offspring of high saturated fat diet-fed Sprague-Dawley dams
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    50 mg/kg twice daily · intraperitoneal injection · 3 weeksAs given in this study (rat).

    Source sentences

    Summary
    The beneficial effects of AICAR therapy in pregnancy is related to restoration of NO pathway.
    1 context sentence
    Summary · context
    Pregnant Sprague-Dawley rats received regular chow or high saturated fat diet (HFD) throughout pregnancy and lactation. AICAR treatment was introduced by intraperitoneal injection at 50 mg/kg twice a day for 3 weeks throughout the pregnancy period (AICAR/P) or lactation period (AICAR/L).
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rat offspring, maternal AICAR during pregnancy diminished HFD-induced oxidative stress.

    In plain wordsIn rats, maternal AICAR during pregnancy reduced oxidative stress compared with HFD alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseOxidative stress after pregnancy treatment
    Study

    ratn: not reported in source

    male offspring of high saturated fat diet-fed Sprague-Dawley dams
    Comparator
    HFD without AICAR
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    50 mg/kg twice daily · intraperitoneal injection · 3 weeksAs given in this study (rat).

    Source sentences

    Summary
    While AICAR uses in pregnancy and lactation both diminished oxidative stress induced by HFD.
    1 context sentence
    Summary · context
    Pregnant Sprague-Dawley rats received regular chow or high saturated fat diet (HFD) throughout pregnancy and lactation. AICAR treatment was introduced by intraperitoneal injection at 50 mg/kg twice a day for 3 weeks throughout the pregnancy period (AICAR/P) or lactation period (AICAR/L).
  9. 09AnimalAnimal study (in vivo)Mechanism

    In rat offspring, maternal AICAR during lactation diminished HFD-induced oxidative stress.

    In plain wordsIn rats, maternal AICAR during lactation reduced oxidative stress compared with HFD alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseOxidative stress after lactation treatment
    Study

    ratn: not reported in source

    male offspring of high saturated fat diet-fed Sprague-Dawley dams
    Comparator
    HFD without AICAR
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    50 mg/kg twice daily · intraperitoneal injection · 3 weeksAs given in this study (rat).

    Source sentences

    Summary
    While AICAR uses in pregnancy and lactation both diminished oxidative stress induced by HFD.
    1 context sentence
    Summary · context
    Pregnant Sprague-Dawley rats received regular chow or high saturated fat diet (HFD) throughout pregnancy and lactation. AICAR treatment was introduced by intraperitoneal injection at 50 mg/kg twice a day for 3 weeks throughout the pregnancy period (AICAR/P) or lactation period (AICAR/L).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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