Brain AMPK signaling improves intestinal barrier function through brain orexin and the vagal pathway in rats.

Funayama T, Nozu T, Ishioh M, Sumi C, Saito T, Hatayama M, Yamamoto M, Shindo M, Takahashi S, Okumura T

Neuroscience letters28 Mar 2025Cited by 3 (Europe PMC)

PMID40158792DOI10.1016/j.neulet.2025.138208PepBankPUB-40158792

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, intracisternal AICAR reduced LPS-induced colonic hyperpermeability.
In plain wordsIn rats, AICAR delivered into the brain reduced LPS-induced colon leakage.
Peptide
AICAR (acadesine)
Outcome
DecreaseColonic hyperpermeability after central AICAR
Study
ratn: not reported in source
LPS-induced colonic hyperpermeability
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated · intracisternalAs given in this study (rat).
Source sentences
Summary
Intracisternal AICAR, an AMPK activator, could reduce LPS-induced colonic hyperpermeability while peripherally administered AICAR failed to change it.
Report a problemFND-4015879201
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, peripheral AICAR did not change LPS-induced colonic hyperpermeability.
In plain wordsIn rats, peripheral AICAR did not change LPS-induced colon leakage.
Peptide
AICAR (acadesine)
Outcome
No significant changeColonic hyperpermeability after peripheral AICAR
Study
ratn: not reported in source
LPS-induced colonic hyperpermeability
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated · peripheralAs given in this study (rat).
Source sentences
Summary
Intracisternal AICAR, an AMPK activator, could reduce LPS-induced colonic hyperpermeability while peripherally administered AICAR failed to change it.
Report a problemFND-4015879202

Studies that did not test the peptide alone8

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

03AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In rats, intracisternal compound C blocked AICAR-associated improvement in colonic hyperpermeability.
In plain wordsIn rats, compound C delivered into the brain blocked AICAR-associated improvement in colon leakage.
Peptide
AICAR (acadesine)
Outcome
DecreaseCentral AMPK inhibition of AICAR response
Study
ratn: not reported in source
LPS-induced colonic hyperpermeability
Outcome group
Gastrointestinal protection · Gastrointestinal
Source sentences
Summary
The improvement of colonic hyperpermeability by intracisternal AICAR was blocked by intracisternal but not subcutaneous compound C, AMPK inhibitor, atropine or vagotomy.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-4015879203
04AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In rats, subcutaneous compound C did not block AICAR-associated improvement in colonic hyperpermeability.
In plain wordsIn rats, compound C injected under the skin did not block AICAR-associated improvement in colon leakage.
Peptide
AICAR (acadesine)
Outcome
No significant changePeripheral AMPK inhibition of AICAR response
Study
ratn: not reported in source
LPS-induced colonic hyperpermeability
Outcome group
Gastrointestinal protection · Gastrointestinal
Source sentences
Summary
The improvement of colonic hyperpermeability by intracisternal AICAR was blocked by intracisternal but not subcutaneous compound C, AMPK inhibitor, atropine or vagotomy.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-4015879204
05AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In rats, atropine blocked AICAR-associated improvement in colonic hyperpermeability.
In plain wordsIn rats, atropine blocked AICAR-associated improvement in colon leakage.
Peptide
AICAR (acadesine)
Outcome
DecreaseAtropine inhibition of AICAR response
Study
ratn: not reported in source
LPS-induced colonic hyperpermeability
Outcome group
Gastrointestinal protection · Gastrointestinal
Source sentences
Summary
The improvement of colonic hyperpermeability by intracisternal AICAR was blocked by intracisternal but not subcutaneous compound C, AMPK inhibitor, atropine or vagotomy.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-4015879205
06AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In rats, vagotomy blocked AICAR-associated improvement in colonic hyperpermeability.
In plain wordsIn rats, cutting the vagus nerve blocked AICAR-associated improvement in colon leakage.
Peptide
AICAR (acadesine)
Outcome
DecreaseVagotomy inhibition of AICAR response
Study
ratn: not reported in source
LPS-induced colonic hyperpermeability
Outcome group
Gastrointestinal protection · Gastrointestinal
Source sentences
Summary
The improvement of colonic hyperpermeability by intracisternal AICAR was blocked by intracisternal but not subcutaneous compound C, AMPK inhibitor, atropine or vagotomy.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-4015879206
07AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In rats, intracisternal orexin receptor antagonist blocked AICAR-associated improvement in colonic hyperpermeability.
In plain wordsIn rats, blocking brain orexin receptors blocked AICAR-associated improvement in colon leakage.
Peptide
AICAR (acadesine)
Outcome
DecreaseOrexin receptor blockade of AICAR response
Study
ratn: not reported in source
LPS-induced colonic hyperpermeability
Outcome group
Gastrointestinal protection · Gastrointestinal
Source sentences
Summary
The improvement of colonic hyperpermeability by intracisternal AICAR was blocked by intracisternal orexin receptor antagonist but not oxytocin or GLP-1 receptor antagonist.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-4015879207
08AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In rats, oxytocin receptor antagonist did not block AICAR-associated improvement in colonic hyperpermeability.
In plain wordsIn rats, blocking oxytocin receptors did not block AICAR-associated improvement in colon leakage.
Peptide
AICAR (acadesine)
Outcome
No significant changeOxytocin receptor blockade of AICAR response
Study
ratn: not reported in source
LPS-induced colonic hyperpermeability
Outcome group
Gastrointestinal protection · Gastrointestinal
Source sentences
Summary
The improvement of colonic hyperpermeability by intracisternal AICAR was blocked by intracisternal orexin receptor antagonist but not oxytocin or GLP-1 receptor antagonist.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-4015879208
09AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In rats, GLP-1 receptor antagonist did not block AICAR-associated improvement in colonic hyperpermeability.
In plain wordsIn rats, blocking GLP-1 receptors did not block AICAR-associated improvement in colon leakage.
Peptide
AICAR (acadesine)
Outcome
No significant changeGLP-1 receptor blockade of AICAR response
Study
ratn: not reported in source
LPS-induced colonic hyperpermeability
Outcome group
Gastrointestinal protection · Gastrointestinal
Source sentences
Summary
The improvement of colonic hyperpermeability by intracisternal AICAR was blocked by intracisternal orexin receptor antagonist but not oxytocin or GLP-1 receptor antagonist.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-4015879209
10AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In rats, intracisternal compound C prevented brain oxytocin-induced improvement in colonic hyperpermeability.
In plain wordsIn rats, compound C delivered into the brain prevented oxytocin-associated improvement in colon leakage.
Peptide
Oxytocin
Outcome
DecreaseAMPK inhibition of oxytocin response
Study
ratn: not reported in source
LPS-induced colonic hyperpermeability
Outcome group
Gastrointestinal protection · Gastrointestinal
Source sentences
Summary
Intracisternal compound C prevented brain oxytocin or GLP-1 but not orexin-induced improvement of colonic hyperpermeability.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-4015879210

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 2
21 Oct 2026, 12:50 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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