Post-treatment with the combination of 5-aminoimidazole-4-carboxyamide ribonucleoside and carnitine improves renal function after ischemia/reperfusion injury.

Idrovo JP, Yang WL, Matsuda A, Nicastro J, Coppa GF, Wang P

Shock (Augusta, Ga.)1 Jan 2012Cited by 20 (Europe PMC)

PMID21841537PMCIDPMC3237783DOI10.1097/shk.0b013e31823185d7PepBankPUB-21841537

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with renal I/R, AICAR alone did not significantly improve most measurements versus vehicle.
In plain wordsIn rats with renal I/R, AICAR alone did not significantly improve most measurements versus vehicle.
Peptide
AICAR (acadesine)
Outcome
No significant changeMost measured outcomes
Study
ratn: not reported in source
renal ischemia/reperfusion
Comparator
Vehicle
Outcome group
Kidney function · Kidney and urinary
Studied dose
30 mg/kg BWAs given in this study (rat).
Source sentences
Summary
In contrast, administration of either drug alone did not show a significant improvement in most of the measurements.
1 context sentence(design, population, supporting numbers)
Summary · context
Male adult rats were subjected to renal I/R by bilateral renal pedicle clamping for 60 min, followed by administration of saline (vehicle), carnitine (250 mg/kg BW), AICAR (30 mg/kg BW), or combination of both drugs.
Report a problemFND-2184153711

Studies that did not test the peptide alone10

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

02AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In rats with renal I/R, combined carnitine and AICAR increased CPT1 activity versus vehicle.
In plain wordsIn rats with renal I/R, combined carnitine and AICAR increased CPT1 activity versus vehicle.
Peptide
AICAR (acadesine)
Outcome
IncreaseCPT1 activity
Study
ratn: not reported in source
renal ischemia/reperfusion
Comparator
Vehicle
Outcome group
Mitochondrial function · Kidney and urinary
Source sentences
Summary
The combined treatment significantly increased CPT1 activity and ATP levels and lowered renal malondialdehyde and serum TNF-α levels against the vehicle group.
1 context sentence(design, population, supporting numbers)
Summary · context
Male adult rats were subjected to renal I/R by bilateral renal pedicle clamping for 60 min, followed by administration of saline (vehicle), carnitine (250 mg/kg BW), AICAR (30 mg/kg BW), or combination of both drugs.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2184153701
03AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In rats with renal I/R, combined carnitine and AICAR increased ATP levels versus vehicle.
In plain wordsIn rats with renal I/R, combined carnitine and AICAR increased ATP levels versus vehicle.
Peptide
AICAR (acadesine)
Outcome
IncreaseATP levels
Study
ratn: not reported in source
renal ischemia/reperfusion
Comparator
Vehicle
Outcome group
Mitochondrial function · Kidney and urinary
Source sentences
Summary
The combined treatment significantly increased CPT1 activity and ATP levels and lowered renal malondialdehyde and serum TNF-α levels against the vehicle group.
1 context sentence(design, population, supporting numbers)
Summary · context
Male adult rats were subjected to renal I/R by bilateral renal pedicle clamping for 60 min, followed by administration of saline (vehicle), carnitine (250 mg/kg BW), AICAR (30 mg/kg BW), or combination of both drugs.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2184153702
04AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In rats with renal I/R, combined carnitine and AICAR lowered renal malondialdehyde versus vehicle.
In plain wordsIn rats with renal I/R, combined carnitine and AICAR lowered renal malondialdehyde versus vehicle.
Peptide
AICAR (acadesine)
Outcome
DecreaseRenal malondialdehyde
Study
ratn: not reported in source
renal ischemia/reperfusion
Comparator
Vehicle
Outcome group
Oxidative stress · Kidney and urinary
Source sentences
Summary
The combined treatment significantly increased CPT1 activity and ATP levels and lowered renal malondialdehyde and serum TNF-α levels against the vehicle group.
1 context sentence(design, population, supporting numbers)
Summary · context
Male adult rats were subjected to renal I/R by bilateral renal pedicle clamping for 60 min, followed by administration of saline (vehicle), carnitine (250 mg/kg BW), AICAR (30 mg/kg BW), or combination of both drugs.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2184153703
05AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In rats with renal I/R, combined carnitine and AICAR lowered serum TNF-α versus vehicle.
In plain wordsIn rats with renal I/R, combined carnitine and AICAR lowered serum TNF-α versus vehicle.
Peptide
AICAR (acadesine)
Outcome
DecreaseSerum TNF-α
Study
ratn: not reported in source
renal ischemia/reperfusion
Comparator
Vehicle
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
The combined treatment significantly increased CPT1 activity and ATP levels and lowered renal malondialdehyde and serum TNF-α levels against the vehicle group.
1 context sentence(design, population, supporting numbers)
Summary · context
Male adult rats were subjected to renal I/R by bilateral renal pedicle clamping for 60 min, followed by administration of saline (vehicle), carnitine (250 mg/kg BW), AICAR (30 mg/kg BW), or combination of both drugs.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2184153704
06AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Efficacy outcome
In rats with renal I/R, combined carnitine and AICAR improved renal morphology versus vehicle.
In plain wordsIn rats with renal I/R, combined carnitine and AICAR improved renal morphology versus vehicle.
Peptide
AICAR (acadesine)
Outcome
Direction not reportedRenal morphology
Study
ratn: not reported in source
renal ischemia/reperfusion
Comparator
Vehicle
Outcome group
Kidney function · Kidney and urinary
Source sentences
Summary
It led to improvement in renal morphology and histological damage score associated with diminution in serum creatinine, blood urea nitrogen, and aspartate aminotransferase levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Male adult rats were subjected to renal I/R by bilateral renal pedicle clamping for 60 min, followed by administration of saline (vehicle), carnitine (250 mg/kg BW), AICAR (30 mg/kg BW), or combination of both drugs.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2184153705
07AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Efficacy outcome
In rats with renal I/R, combined carnitine and AICAR improved histological damage scores versus vehicle.
In plain wordsIn rats with renal I/R, combined carnitine and AICAR improved histological damage scores versus vehicle.
Peptide
AICAR (acadesine)
Outcome
DecreaseHistological damage score
Study
ratn: not reported in source
renal ischemia/reperfusion
Comparator
Vehicle
Outcome group
Kidney function · Kidney and urinary
Source sentences
Summary
It led to improvement in renal morphology and histological damage score associated with diminution in serum creatinine, blood urea nitrogen, and aspartate aminotransferase levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Male adult rats were subjected to renal I/R by bilateral renal pedicle clamping for 60 min, followed by administration of saline (vehicle), carnitine (250 mg/kg BW), AICAR (30 mg/kg BW), or combination of both drugs.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2184153706
08AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Efficacy outcome
In rats with renal I/R, combined carnitine and AICAR lowered serum creatinine versus vehicle.
In plain wordsIn rats with renal I/R, combined carnitine and AICAR lowered serum creatinine versus vehicle.
Peptide
AICAR (acadesine)
Outcome
DecreaseSerum creatinine
Study
ratn: not reported in source
renal ischemia/reperfusion
Comparator
Vehicle
Outcome group
Kidney function · Kidney and urinary
Source sentences
Summary
It led to improvement in renal morphology and histological damage score associated with diminution in serum creatinine, blood urea nitrogen, and aspartate aminotransferase levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Male adult rats were subjected to renal I/R by bilateral renal pedicle clamping for 60 min, followed by administration of saline (vehicle), carnitine (250 mg/kg BW), AICAR (30 mg/kg BW), or combination of both drugs.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2184153707
09AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Efficacy outcome
In rats with renal I/R, combined carnitine and AICAR lowered blood urea nitrogen versus vehicle.
In plain wordsIn rats with renal I/R, combined carnitine and AICAR lowered blood urea nitrogen versus vehicle.
Peptide
AICAR (acadesine)
Outcome
DecreaseBlood urea nitrogen
Study
ratn: not reported in source
renal ischemia/reperfusion
Comparator
Vehicle
Outcome group
Kidney function · Kidney and urinary
Source sentences
Summary
It led to improvement in renal morphology and histological damage score associated with diminution in serum creatinine, blood urea nitrogen, and aspartate aminotransferase levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Male adult rats were subjected to renal I/R by bilateral renal pedicle clamping for 60 min, followed by administration of saline (vehicle), carnitine (250 mg/kg BW), AICAR (30 mg/kg BW), or combination of both drugs.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2184153708
10AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Efficacy outcome
In rats with renal I/R, combined carnitine and AICAR lowered aspartate aminotransferase versus vehicle.
In plain wordsIn rats with renal I/R, combined carnitine and AICAR lowered aspartate aminotransferase versus vehicle.
Peptide
AICAR (acadesine)
Outcome
DecreaseAspartate aminotransferase
Study
ratn: not reported in source
renal ischemia/reperfusion
Comparator
Vehicle
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
It led to improvement in renal morphology and histological damage score associated with diminution in serum creatinine, blood urea nitrogen, and aspartate aminotransferase levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Male adult rats were subjected to renal I/R by bilateral renal pedicle clamping for 60 min, followed by administration of saline (vehicle), carnitine (250 mg/kg BW), AICAR (30 mg/kg BW), or combination of both drugs.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2184153709
11AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Efficacy outcome
In rats with renal I/R, combined carnitine and AICAR increased survival versus vehicle.
In plain wordsIn rats with renal I/R, combined carnitine and AICAR increased survival versus vehicle.
Peptide
AICAR (acadesine)
Outcome
IncreaseSurvival
Study
ratn: not reported in source
renal ischemia/reperfusion
Comparator
Vehicle
Outcome group
Mortality · Whole body
Source sentences
Summary
Moreover, the combined treatment significantly improved the survival rate in comparison to the vehicle group.
1 context sentence(design, population, supporting numbers)
Summary · context
Male adult rats were subjected to renal I/R by bilateral renal pedicle clamping for 60 min, followed by administration of saline (vehicle), carnitine (250 mg/kg BW), AICAR (30 mg/kg BW), or combination of both drugs.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2184153710

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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