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Study · Animal study (in vivo) · rat · 2015

15 results

Estradiol regulates effects of hindbrain activator 5-aminoimidazole-4-carboxamide-riboside administration on hypothalamic adenosine 5'-monophosphate-activated protein kinase activity and metabolic neurotransmitter mRNA and protein expression.

Alenazi FS, Ibrahim BA, Briski KP

Journal of neuroscience research4 Dec 2014Cited by 11 (Europe PMC)

PMID25476093 (opens in a new tab)DOI10.1002/jnr.23520 (opens in a new tab)PepBankPUB-25476093
Publisher pagePubMedAsk about this study
Jump to 15 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In ovariectomized rats, AICAR decreased PVH corticotrophin-releasing hormone gene expression in oil and estradiol strata.

    In plain wordsIn rats, AICAR reduced this hormone's gene expression in both implant groups versus saline.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreasePVH CRH gene expression
    Study

    ratn: not reported in source

    Ovariectomized female rats with estradiol or oil implants
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · fourth ventricleAs given in this study (rat).

    Source sentences

    Summary
    PVH corticotrophin-releasing hormone gene and protein profiles were decreased in O/A and E/A animals.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In ovariectomized rats, AICAR decreased PVH corticotrophin-releasing hormone protein in oil and estradiol strata.

    In plain wordsIn rats, AICAR reduced this hormone's protein in both implant groups versus saline.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreasePVH CRH protein
    Study

    ratn: not reported in source

    Ovariectomized female rats with estradiol or oil implants
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · fourth ventricleAs given in this study (rat).

    Source sentences

    Summary
    PVH corticotrophin-releasing hormone gene and protein profiles were decreased in O/A and E/A animals.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In oil-implanted rats, AICAR increased ARH POMC mRNA.

    In plain wordsIn rats with oil implants, AICAR increased POMC gene activity versus saline.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseARH POMC mRNA with oil
    Study

    ratn: not reported in source

    Ovariectomized female rats with estradiol or oil implants
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · fourth ventricleAs given in this study (rat).

    Source sentences

    Summary
    ARH pro-opiomelanocortin (POMC) mRNA and protein were both elevated in O/A but were diminished or unchanged, respectively, in E/A animals; ARH neuropeptide Y (NPY) transcription was inhibited in O/A and E/A animals, but neuropeptide content was augmented in E/A only.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In oil-implanted rats, AICAR increased ARH POMC protein.

    In plain wordsIn rats with oil implants, AICAR increased POMC protein versus saline.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseARH POMC protein with oil
    Study

    ratn: not reported in source

    Ovariectomized female rats with estradiol or oil implants
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · fourth ventricleAs given in this study (rat).

    Source sentences

    Summary
    ARH pro-opiomelanocortin (POMC) mRNA and protein were both elevated in O/A but were diminished or unchanged, respectively, in E/A animals; ARH neuropeptide Y (NPY) transcription was inhibited in O/A and E/A animals, but neuropeptide content was augmented in E/A only.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In estradiol-implanted rats, AICAR decreased ARH POMC mRNA.

    In plain wordsIn rats with estradiol implants, AICAR reduced POMC gene activity versus saline.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseARH POMC mRNA with estradiol
    Study

    ratn: not reported in source

    Ovariectomized female rats with estradiol or oil implants
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · fourth ventricleAs given in this study (rat).

    Source sentences

    Summary
    ARH pro-opiomelanocortin (POMC) mRNA and protein were both elevated in O/A but were diminished or unchanged, respectively, in E/A animals; ARH neuropeptide Y (NPY) transcription was inhibited in O/A and E/A animals, but neuropeptide content was augmented in E/A only.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In estradiol-implanted rats, AICAR did not change ARH POMC protein.

    In plain wordsIn rats with estradiol implants, AICAR did not change POMC protein versus saline.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeARH POMC protein with estradiol
    Study

    ratn: not reported in source

    Ovariectomized female rats with estradiol or oil implants
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · fourth ventricleAs given in this study (rat).

    Source sentences

    Summary
    ARH pro-opiomelanocortin (POMC) mRNA and protein were both elevated in O/A but were diminished or unchanged, respectively, in E/A animals; ARH neuropeptide Y (NPY) transcription was inhibited in O/A and E/A animals, but neuropeptide content was augmented in E/A only.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR inhibited ARH NPY transcription in oil and estradiol strata.

    In plain wordsIn rats, AICAR reduced NPY gene activity in both implant groups versus saline.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseARH NPY transcription
    Study

    ratn: not reported in source

    Ovariectomized female rats with estradiol or oil implants
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · fourth ventricleAs given in this study (rat).

    Source sentences

    Summary
    ARH pro-opiomelanocortin (POMC) mRNA and protein were both elevated in O/A but were diminished or unchanged, respectively, in E/A animals; ARH neuropeptide Y (NPY) transcription was inhibited in O/A and E/A animals, but neuropeptide content was augmented in E/A only.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In estradiol-implanted rats, AICAR increased ARH NPY content.

    In plain wordsIn rats with estradiol implants, AICAR increased NPY protein versus saline.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseARH NPY protein with estradiol
    Study

    ratn: not reported in source

    Ovariectomized female rats with estradiol or oil implants
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · fourth ventricleAs given in this study (rat).

    Source sentences

    Summary
    ARH pro-opiomelanocortin (POMC) mRNA and protein were both elevated in O/A but were diminished or unchanged, respectively, in E/A animals; ARH neuropeptide Y (NPY) transcription was inhibited in O/A and E/A animals, but neuropeptide content was augmented in E/A only.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR reduced VMH SF-1 mRNA in oil and estradiol strata.

    In plain wordsIn rats, AICAR reduced SF-1 gene activity in both implant groups versus saline.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseVMH SF-1 mRNA
    Study

    ratn: not reported in source

    Ovariectomized female rats with estradiol or oil implants
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · fourth ventricleAs given in this study (rat).

    Source sentences

    Summary
    VMH SF-1 mRNA and protein were reduced in O and E animals.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR reduced VMH SF-1 protein in oil and estradiol strata.

    In plain wordsIn rats, AICAR reduced SF-1 protein in both implant groups versus saline.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseVMH SF-1 protein
    Study

    ratn: not reported in source

    Ovariectomized female rats with estradiol or oil implants
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · fourth ventricleAs given in this study (rat).

    Source sentences

    Summary
    VMH SF-1 mRNA and protein were reduced in O and E animals.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR did not alter AMPK protein in any examined hypothalamic structure.

    In plain wordsIn rats, AICAR did not change AMPK protein in the examined brain regions versus saline.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeHypothalamic AMPK protein
    Study

    ratn: not reported in source

    Ovariectomized female rats with estradiol or oil implants
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · fourth ventricleAs given in this study (rat).

    Source sentences

    Summary
    AICAR did not alter AMPK protein in any structure but elevated PVH (↑E), did not alter ARH, and decreased VMH (↓O,↓E) pAMPK.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In estradiol-implanted rats, AICAR increased PVH pAMPK.

    In plain wordsIn rats with estradiol implants, AICAR increased activated AMPK in the PVH versus saline.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePVH pAMPK with estradiol
    Study

    ratn: not reported in source

    Ovariectomized female rats with estradiol or oil implants
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · fourth ventricleAs given in this study (rat).

    Source sentences

    Summary
    AICAR did not alter AMPK protein in any structure but elevated PVH (↑E), did not alter ARH, and decreased VMH (↓O,↓E) pAMPK.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR did not alter ARH pAMPK.

    In plain wordsIn rats, AICAR did not change activated AMPK in the ARH versus saline.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeARH pAMPK
    Study

    ratn: not reported in source

    Ovariectomized female rats with estradiol or oil implants
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · fourth ventricleAs given in this study (rat).

    Source sentences

    Summary
    AICAR did not alter AMPK protein in any structure but elevated PVH (↑E), did not alter ARH, and decreased VMH (↓O,↓E) pAMPK.
  14. 14AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR decreased VMH pAMPK in oil and estradiol strata.

    In plain wordsIn rats, AICAR reduced activated AMPK in the VMH in both implant groups versus saline.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseVMH pAMPK
    Study

    ratn: not reported in source

    Ovariectomized female rats with estradiol or oil implants
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · fourth ventricleAs given in this study (rat).

    Source sentences

    Summary
    AICAR did not alter AMPK protein in any structure but elevated PVH (↑E), did not alter ARH, and decreased VMH (↓O,↓E) pAMPK.
  15. 15AnimalAnimal study (in vivo)Mechanism

    In oil-implanted ovariectomized rats, AICAR decreased ARH NPY neuropeptide content versus saline.

    In plain wordsIn rats with oil implants, AICAR reduced ARH NPY protein versus saline.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseARH NPY protein with oil
    Study

    ratn: not reported in source

    Ovariectomized female rats with oil implants
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · fourth ventricleAs given in this study (rat).

    Source sentences

    Summary
    Dissimilar POMC (↑O vs. ↔E) and NPY (↓O vs. ↑E) neuropeptide responses to caudal fourth ventricle AICAR indicate E regulation of hindbrain AMPK signaling and/or target receptivity, implying that ARH-controlled metabolic responses may differ in the presence vs. absence of E.
    1 context sentence
    Summary · context
    E- or oil (O)-implanted ovariectomized female rats that had been injected, into the fourth ventricle, with the AMPK activator 5-aminoimidazole-4-carboxamide-riboside (AICAR; A) or saline (S)

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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