Differential attenuation of AMPK activation during acute exercise following exercise training or AICAR treatment.

McConell GK, Manimmanakorn A, Lee-Young RS, Kemp BE, Linden KC, Wadley GD

Journal of applied physiology (Bethesda, Md. : 1985)14 Aug 2008Cited by 20 (Europe PMC)

PMID18703760DOI10.1152/japplphysiol.01371.2007PepBankPUB-18703760

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats, AICAR pretreatment attenuated exercise-induced soleus AMPKalpha phosphorylation, with a nonsignificant 1.3-fold increase during exercise.
In plain wordsIn rats, AICAR pretreatment reduced the exercise-induced AMPKalpha phosphorylation response compared with no pretreatment.
Peptide
AICAR (acadesine)
Outcome
DecreaseSoleus AMPKalpha phosphorylation response
Study
ratn: not reported in source
male Sprague-Dawley rats during treadmill exercise
Comparator
no training or AICAR pretreatment
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
0.5 mg/g body weight · intraperitoneal · 10 daysAs given in this study (rat).
Measurements
p-AMPKalpha increase
1.3 fold
during exercise after AICAR; nonsignificant
Source sentences
Summary
Ten days of AICAR administration also attenuated the exercise-induced increases in AMPK signaling in the soleus although not as effectively as 10 days of exercise training (nonsignificant 1.3-fold increase in p-AMPKalpha; significant 3-fold increase in p-ACCbeta).
1 context sentence(design, population, supporting numbers)
Summary · context
We compared the effect of 10 days of treadmill training (60 min/day) with 10 days of AICAR administration (0.5 mg/g body weight ip) on subsequent AMPK activation during 45 min of treadmill exercise in male Sprague-Dawley rats.
Report a problemFND-1870376001
02AnimalAnimal study (in vivo)Mechanism
In rats, AICAR pretreatment attenuated exercise-induced soleus ACCbeta phosphorylation, with a significant 3-fold increase during exercise.
In plain wordsIn rats, AICAR pretreatment reduced the exercise-induced ACCbeta phosphorylation response compared with no pretreatment.
Peptide
AICAR (acadesine)
Outcome
DecreaseSoleus ACCbeta phosphorylation response
Study
ratn: not reported in source
male Sprague-Dawley rats during treadmill exercise
Comparator
no training or AICAR pretreatment
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
0.5 mg/g body weight · intraperitoneal · 10 daysAs given in this study (rat).
Measurements
p-ACCbeta increase
3 fold
during exercise after AICAR; significant
Source sentences
Summary
Ten days of AICAR administration also attenuated the exercise-induced increases in AMPK signaling in the soleus although not as effectively as 10 days of exercise training (nonsignificant 1.3-fold increase in p-AMPKalpha; significant 3-fold increase in p-ACCbeta).
1 context sentence(design, population, supporting numbers)
Summary · context
We compared the effect of 10 days of treadmill training (60 min/day) with 10 days of AICAR administration (0.5 mg/g body weight ip) on subsequent AMPK activation during 45 min of treadmill exercise in male Sprague-Dawley rats.
Report a problemFND-1870376002
03AnimalAnimal study (in vivo)Mechanism
In rats, AICAR pretreatment attenuated exercise-induced soleus AMPK signaling less effectively than exercise training.
In plain wordsIn rats, AICAR pretreatment reduced the muscle AMPK response to exercise less effectively than exercise training.
Peptide
AICAR (acadesine)
Outcome
DecreaseAMPK signaling attenuation versus training
Study
ratn: not reported in source
male Sprague-Dawley rats during treadmill exercise
Comparator
10 days of exercise training
Outcome group
Receptor activity and mechanism · Musculoskeletal
Studied dose
0.5 mg/g body weight · intraperitoneal · 10 daysAs given in this study (rat).
Source sentences
Summary
Ten days of AICAR administration also attenuated the exercise-induced increases in AMPK signaling in the soleus although not as effectively as 10 days of exercise training (nonsignificant 1.3-fold increase in p-AMPKalpha; significant 3-fold increase in p-ACCbeta).
1 context sentence(design, population, supporting numbers)
Summary · context
We compared the effect of 10 days of treadmill training (60 min/day) with 10 days of AICAR administration (0.5 mg/g body weight ip) on subsequent AMPK activation during 45 min of treadmill exercise in male Sprague-Dawley rats.
Report a problemFND-1870376003
04AnimalAnimal study (in vivo)Mechanism
In rats, AICAR pretreatment increased the rise in skeletal muscle 2-deoxyglucose uptake during exercise.
In plain wordsIn rats, AICAR pretreatment increased muscle glucose uptake during exercise compared with no pretreatment.
Peptide
AICAR (acadesine)
Outcome
IncreaseExercise-induced muscle glucose uptake
Study
ratn: not reported in source
male Sprague-Dawley rats during treadmill exercise
Comparator
no training or AICAR pretreatment
Outcome group
Glycemic control · Metabolic and weight
Studied dose
0.5 mg/g body weight · intraperitoneal · 10 daysAs given in this study (rat).
Source sentences
Summary
The increase in skeletal muscle 2-deoxyglucose uptake during exercise was greater after either 10 days of exercise training or AICAR administration.
1 context sentence(design, population, supporting numbers)
Summary · context
We compared the effect of 10 days of treadmill training (60 min/day) with 10 days of AICAR administration (0.5 mg/g body weight ip) on subsequent AMPK activation during 45 min of treadmill exercise in male Sprague-Dawley rats.
Report a problemFND-1870376004

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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