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Study · Animal study (in vivo) · rat · 2011

6 results

Reductions in RIP140 are not required for exercise- and AICAR-mediated increases in skeletal muscle mitochondrial content.

Frier BC, Hancock CR, Little JP, Fillmore N, Bliss TA, Thomson DM, Wan Z, Wright DC

Journal of applied physiology (Bethesda, Md. : 1985)23 Jun 2011Cited by 18 (Europe PMC)

PMID21700896 (opens in a new tab)DOI10.1152/japplphysiol.00279.2011 (opens in a new tab)PepBankPUB-21700896
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rat skeletal muscle, daily AICAR injections for 6 wk did not change RIP140 protein content.

    In plain wordsIn rats, daily AICAR injections for 6 wk did not change muscle RIP140 protein levels.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeRIP140 protein content after chronic treatment
    Study

    ratn: not reported in source

    Skeletal muscle
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated · injection · 6 wkAs given in this study (rat).

    Source sentences

    Summary
    We found that 6 wk of daily 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) injections had no effect on RIP140 protein content in rat skeletal muscle
  2. 02AnimalAnimal study (in vivo)Mechanism

    In skeletal muscle, acute AICAR treatment increased PGC-1α mRNA levels.

    In plain wordsIn skeletal muscle, acute AICAR treatment increased PGC-1α gene activity.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePGC-1alpha mRNA after acute treatment
    Study

    n: not reported in source

    Skeletal muscle
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    An acute bout of exercise, AICAR treatment, and epinephrine injections increased the mRNA levels of PGC-1α, COXIV, and lipin1 independent of decreases in nuclear RIP140 protein.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In skeletal muscle, acute AICAR treatment increased COXIV mRNA levels.

    In plain wordsIn skeletal muscle, acute AICAR treatment increased COXIV gene activity.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseCOXIV mRNA after acute treatment
    Study

    n: not reported in source

    Skeletal muscle
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    An acute bout of exercise, AICAR treatment, and epinephrine injections increased the mRNA levels of PGC-1α, COXIV, and lipin1 independent of decreases in nuclear RIP140 protein.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In skeletal muscle, acute AICAR treatment increased lipin1 mRNA levels.

    In plain wordsIn skeletal muscle, acute AICAR treatment increased lipin1 gene activity.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseLipin1 mRNA after acute treatment
    Study

    n: not reported in source

    Skeletal muscle
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    An acute bout of exercise, AICAR treatment, and epinephrine injections increased the mRNA levels of PGC-1α, COXIV, and lipin1 independent of decreases in nuclear RIP140 protein.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In skeletal muscle, acute AICAR treatment did not decrease nuclear RIP140 protein.

    In plain wordsIn skeletal muscle, acute AICAR treatment did not decrease nuclear RIP140 protein.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeNuclear RIP140 protein after acute treatment
    Study

    n: not reported in source

    Skeletal muscle
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    An acute bout of exercise, AICAR treatment, and epinephrine injections increased the mRNA levels of PGC-1α, COXIV, and lipin1 independent of decreases in nuclear RIP140 protein.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In skeletal muscle, acute AICAR treatment increased RIP140 mRNA expression.

    In plain wordsIn skeletal muscle, acute AICAR treatment increased RIP140 gene activity.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseRIP140 mRNA after acute treatment
    Study

    n: not reported in source

    Skeletal muscle
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Surprisingly these interventions increased RIP140 mRNA expression.
    1 context sentence
    Summary · context
    An acute bout of exercise, AICAR treatment, and epinephrine injections increased the mRNA levels of PGC-1α, COXIV, and lipin1 independent of decreases in nuclear RIP140 protein.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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