Elamipretide (SS-31) studies: 372 papers with results
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- Targeting ANT1 to regulate PINK1/Parkin-mediated mitophagy is an effective treatment of trauma-induced tendon heterotopic ossification.
Li G · Journal of orthopaedic translation · 2025
Animal study (in vivo) · mouse · 2 results
- The potential of mitochondrially-targeted tetrapeptide in protecting against noise-induced hearing impairment.
Kumar NA · Neuroreport · 2025
Animal study (in vivo) · mouse · 2 results
- Elamipretide Rejuvenates Oocyte Quality and Restores Female Fertility During Reproductive Aging.
Zhang HL · Aging cell · 2026
Animal study (in vivo) · mouse · 12 results
- Seawater immersion reshapes the temporal dynamics of traumatic brain injury and reveals mitochondrial oxidative stress as a modifiable therapeutic target.
Li W · Experimental neurology · 2026
Animal study (in vivo) · mouse · 4 results
- Disruption of hippocampal mitochondrial function underlies opioid-induced postoperative cognitive dysfunction in aged rats.
Muscat SM · Brain, behavior, and immunity · 2026
Animal study (in vivo) · rat · 4 results
- Targeting Mitochondria in MASLD: Comparative Evaluation of MitoQ and SS-31 (Elamipretide) in Aged Female Mice under Nutritional Stress.
Xiao D · Physiological research · 2026
Animal study (in vivo) · mouse (aged female c57bl and 6) · 8 results
- SS31 protects damaged retinal cells through the AMPK/DRP1 signaling pathway.
Cui N · Molecular vision · 2026
Animal study (in vivo) · mouse · 5 results
- Peroxiredoxin Ⅲ safeguards cardiac function against doxorubicin by regulating mitochondrial quality control via H2O2 detoxification.
Park JW · Redox biology · 2026
Animal study (in vivo) · mouse · 1 result
- Restoring cardiolipin homeostasis mitigates cerebral ischemia-reperfusion injury by suppressing ATG5-mediated neuronal autophagy-dependent ferroptosis.
Dong W · Journal of advanced research · 2026
Animal study (in vivo) · mouse · 7 results
- Mechanisms of Anti-Oxidants, N-Acetylcysteine and Elamipretide (SS-31), on Ozone-Induced Airway Hyperresponsiveness and Mucus Hypersecretion.
Xie M · Lung · 2026
Animal study (in vivo) · mouse · 13 results
- Cuproptosis of bronchial epithelial cells triggers airway remodeling in chronic asthma.
Wang M · Scientific reports · 2026
Animal study (in vivo) · mouse · 7 results
- Endothelial Glycocalyx Degradation as a Mediator of Neuroinflammation and Cognitive Impairment in Aged Rats: Protective Role of SS-31.
Kan MH · Molecular neurobiology · 2025
Animal study (in vivo) · rat · 3 results
- Environmental enrichment highlights mitochondrial inner membrane function as a therapeutic target for sepsis-associated encephalopathy.
Wang SX · Brain research · 2025
Animal study (in vivo) · mouse · 4 results
- Low expression of Frataxin might contribute to diabetic peripheral neuropathy in a mouse model.
Xia S · Biochemical and biophysical research communications · 2025
Animal study (in vivo) · mouse · 7 results
- Mitochondrial oxidative damage reprograms lipid metabolism of renal tubular epithelial cells in the diabetic kidney
Hou Y · Cell. Mol. Life Sci · 2024
Animal study (in vivo) · 4 results
- Reduction of Elevated Proton Leak Rejuvenates Mitochondria in the Aged Cardiomyocyte
Zhang H · Innovation in aging · 2020
Animal study (in vivo) · mouse and rat · 7 results
- AGED MICE ARE SUSCEPTIBLE TO CARDIAC HYPERTROPHY AFTER 1 WEEK OF CONSUMING A HIGH SUGAR DIET
Valencia A · Innovation in aging · 2019
Animal study (in vivo) · mouse · 4 results
- THE ROLE OF MITOCHONDRIAL ENERGETICS IN CARDIAC AND SKELETAL MUSCLE AGING
Rabinovitch P · Innovation in aging · 2018
Animal study (in vivo) · mouse · 9 results
- Dual action of SS31 via NRF2/HO-1: countering oxidative stress and metabolic dysfunction in ovarian aging.
Zhang G · Journal of ovarian research · 2026
Other design · 6 results
- Antioxidant effect of Elamipretide on bull's sperm cells during freezing/thawing process.
Kowalczyk A · Andrology · 2021
Ex vivo tissue · bull · 2 results
- Targeting mitochondrial cardiolipin and the cytochrome c/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis.
Birk AV · British journal of pharmacology · 2014
Ex vivo tissue · 6 results
- Mitochondrial protein interaction landscape of SS-31.
Chavez JD · Proceedings of the National Academy of Sciences of the United States of America · 2020
Ex vivo tissue · 3 results
- Elamipretide Improves Mitochondrial Function in the Failing Human Heart.
Chatfield KC · JACC. Basic to translational science · 2019
Ex vivo tissue · 4 results
- The targeted anti-oxidant MitoQ causes mitochondrial swelling and depolarization in kidney tissue.
Gottwald EM · Physiological reports · 2018
Ex vivo tissue · 2 results
- Antioxidant treatments do not improve force recovery after fatiguing stimulation of mouse skeletal muscle fibres.
Cheng AJ · The Journal of physiology · 2015
Ex vivo tissue · mouse · 6 results
- The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 diabetes.
Escribano-Lopez I · Scientific reports · 2018
Ex vivo tissue · 9 results
- Mitoprotective therapy preserves chondrocyte viability and prevents cartilage degeneration in an ex vivo model of posttraumatic osteoarthritis.
Delco ML · Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018
Ex vivo tissue · bovine · 4 results
- Defective postreperfusion metabolic recovery directly associates with incident delayed graft function.
Wijermars LG · Kidney international · 2016
Ex vivo tissue · 1 result
- The Mitochondrial Antioxidant SS-31 Modulates Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy in Type 2 Diabetes.
Escribano-López I · Journal of clinical medicine · 2019
Ex vivo tissue · 11 results
- A mitochondrial-targeted antioxidant improves myofilament Ca2+ sensitivity during prolonged low frequency force depression at low PO2.
Gandra PG · The Journal of physiology · 2018
Ex vivo tissue · mouse · 3 results
- Elamipretide as a potential candidate for relieving cryodamage to human spermatozoa during cryopreservation.
Bai H · Cryobiology · 2020
Ex vivo tissue · 7 results
- Cadmium-cardiolipin disruption of respirasome assembly and redox balance through mitochondrial membrane rigidification.
Romanova N · Journal of lipid research · 2025
Ex vivo tissue · rat · 8 results
- Effect of Elamipretide on the Vitrification of Mouse Ovarian Tissue by Freezing.
Yao X · Biopreservation and biobanking · 2024
Ex vivo tissue · mouse · 8 results
- Elamipretide enhances post-thaw rooster sperm quality by mitigating oxidative stress and optimizing mitochondrial function during cryopreservation.
Najafi A · Scientific reports · 2025
Ex vivo tissue · chicken · 7 results
- Mitochondrial connexin43 and mitochondrial KATP channels modulate triggered arrhythmias in mouse ventricular muscle.
Sato H · Pflugers Archiv : European journal of physiology · 2023
Ex vivo tissue · mouse · 1 result
- SS-31 improves the quality of maternally aged oocytes by ameliorating mitochondrial function and metabolism.
Xiong D · Journal of ovarian research · 2026
Ex vivo tissue · mouse · 15 results
- Evaluation of SS-31 as a Potential Strategy for Tendinopathy Treatment: An In Vitro Model.
Zhang X · The American journal of sports medicine · 2022
In vitro (cells) · 6 results
- Reversible Mitochondrial Fragmentation in iPSC-Derived Cardiomyocytes From Children With DCMA, a Mitochondrial Cardiomyopathy.
Rohani L · The Canadian journal of cardiology · 2020
In vitro (cells) · 1 result
- Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease.
Calkins MJ · Human molecular genetics · 2011
In vitro (cells) · mouse · 3 results
- Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons.
Manczak M · Journal of Alzheimer's disease : JAD · 2010
In vitro (cells) · mouse · 5 results
- Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines.
Zhao K · Biochemical pharmacology · 2005
In vitro (cells) · 5 results
- Doxorubicin acts via mitochondrial ROS to stimulate catabolism in C2C12 myotubes.
Gilliam LA · American journal of physiology. Cell physiology · 2012
In vitro (cells) · mouse · 2 results
- Mitochondrial production of reactive oxygen species contributes to the β-adrenergic stimulation of mouse cardiomycytes.
Andersson DC · The Journal of physiology · 2011
In vitro (cells) · mouse · 3 results
- Synergistic Protective Effects of Mitochondrial Division Inhibitor 1 and Mitochondria-Targeted Small Peptide SS31 in Alzheimer's Disease.
Reddy PH · Journal of Alzheimer's disease : JAD · 2018
In vitro (cells) · 11 results
- Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells.
Han Z · The Journal of pharmacology and experimental therapeutics · 2009
In vitro (cells) · bovine · 3 results
- C3a receptor blockade protects podocytes from injury in diabetic nephropathy.
Morigi M · JCI insight · 2020
In vitro (cells) · 1 result
- PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction.
Zhou W · Human molecular genetics · 2019
In vitro (cells) · 2 results
- Peptide SS-31 upregulates frataxin expression and improves the quality of mitochondria: implications in the treatment of Friedreich ataxia.
Zhao H · Scientific reports · 2017
In vitro (cells) · 9 results
- Biomass-related PM2.5 induces mitochondrial fragmentation and dysfunction in human airway epithelial cells.
Gao M · Environmental pollution (Barking, Essex : 1987) · 2022
In vitro (cells) · 3 results
- Mitochondria-targeted antioxidant peptide SS31 attenuates high glucose-induced injury on human retinal endothelial cells.
Li J · Biochemical and biophysical research communications · 2011
In vitro (cells) · 6 results