Elamipretide (SS-31) studies: 372 papers with results
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- Mitochondrial antioxidant elamipretide improves learning and memory impairment induced by chronic sleep deprivation in mice.
Zhang YM · Brain and behavior · 2024
Animal study (in vivo) · mouse · 10 results
- Age-related changes of skeletal muscle metabolic response to contraction are also sex-dependent.
Campbell MD · The Journal of physiology · 2025
Animal study (in vivo) · mouse · 2 results
- Targeting mitochondrial stress with Szeto-Schiller 31 prevents experimental abdominal aortic aneurysm: Crosstalk with endoplasmic reticulum stress.
Navas-Madroñal M · British journal of pharmacology · 2023
Animal study (in vivo) · mouse · 11 results
- Synovial fluid mitochondrial DNA concentration reflects the degree of cartilage damage after naturally occurring articular injury.
Seewald LA · Osteoarthritis and cartilage · 2023
Animal study (in vivo) · equine · 1 result
- Differential Effects of the Mitochondria-Active Tetrapeptide SS-31 (D-Arg-dimethylTyr-Lys-Phe-NH2) and Its Peptidase-Targeted Prodrugs in Experimental Acute Kidney Injury.
Wyss JC · Frontiers in pharmacology · 2019
Animal study (in vivo) · mouse · 5 results
- Anti-VEGFR2 F(ab')2 drug conjugate promotes renal accumulation and glomerular repair in diabetic nephropathy.
Liu D · Nature communications · 2023
Animal study (in vivo) · mouse · 1 result
- The mitochondria-targeted small molecule SS31 delays progression of behavioral deficits by attenuating β-amyloid plaque formation and mitochondrial/synaptic deterioration in APP/PS1 mice.
Jia YL · Biochemical and biophysical research communications · 2023
Animal study (in vivo) · mouse · 7 results
- Treatment of age-related visual impairment with a peptide acting on mitochondria.
Alam NM · Disease models & mechanisms · 2022
Animal study (in vivo) · mouse · 8 results
- SS-31 efficacy in a mouse model of Friedreich ataxia by upregulation of frataxin expression.
Liu Y · Human molecular genetics · 2021
Animal study (in vivo) · mouse · 10 results
- Hypochlorite modified albumins promote cell death in the tubule interstitium in rats via mitochondrial damage in obstructive nephropathy and the protective effects of antioxidant peptides.
Liu ZR · Free radical research · 2018
Animal study (in vivo) · rat · 4 results
- Hepatocyte mitochondrial DNA mediates macrophage immune response in liver injury induced by trichloroethylene.
Gao L · Ecotoxicology and environmental safety · 2024
Animal study (in vivo) · mouse · 3 results
- Platelet Membrane-Encapsulated MSNs Loaded with SS31 Peptide Alleviate Myocardial Ischemia-Reperfusion Injury.
Zhang Z · Journal of functional biomaterials · 2022
Animal study (in vivo) · 3 results
- Experimental coronary artery stenosis accelerates kidney damage in renovascular hypertensive swine.
Sun D · Kidney international · 2015
Animal study (in vivo) · pig · 3 results
- Targeting mitochondria in the aged cerebral vasculature with SS-31, a proteomic study of brain microvessels.
Seman A · GeroScience · 2023
Animal study (in vivo) · mouse · 4 results
- SS31 Confers Cerebral Protection by Reversing Mitochondrial Dysfunction in Early Brain Injury Following Subarachnoid Hemorrhage, via the Nrf2- and PGC-1α-Dependent Pathways.
Zhou J · Neurochemical research · 2023
Animal study (in vivo) · 12 results
- Elamipretide treatment during pregnancy ameliorates the progression of polycystic kidney disease in maternal and neonatal mice with PKD1 mutations.
Daneshgar N · Kidney international · 2022
Animal study (in vivo) · mouse · 6 results
- Adverse Neurological Effects of Short-Term Sleep Deprivation in Aging Mice Are Prevented by SS31 Peptide.
Wu J · Clocks & sleep · 2020
Animal study (in vivo) · mouse · 5 results
- Mitochondrial targeted therapy with elamipretide (MTP-131) as an adjunct to tumor necrosis factor inhibition for traumatic optic neuropathy in the acute setting.
Tse BC · Experimental eye research · 2020
Animal study (in vivo) · mouse · 4 results
- In vivo high-resolution magic angle spinning magnetic and electron paramagnetic resonance spectroscopic analysis of mitochondria-targeted peptide in Drosophila melanogaster with trauma-induced thoracic injury.
Constantinou C · International journal of molecular medicine · 2016
Animal study (in vivo) · drosophila melanogaster · 2 results
- Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 (elamipretide) and development of a high-throughput machine learning-driven imaging pipeline for cerebromicrovascular protection therapeutic screening.
Patai R · GeroScience · 2025
Animal study (in vivo) · mouse · 1 result
- Long-term treatment with Elamipretide enhances healthy aging phenotypes in mice.
Nickel K · Aging pathobiology and therapeutics · 2022
Animal study (in vivo) · mouse · 6 results
- SS31 alleviates LPS-induced acute lung injury by inhibiting inflammatory responses through the S100A8/NLRP3/GSDMD signaling pathway.
Luo P · European journal of medical research · 2024
Animal study (in vivo) · mouse · 8 results
- Skeletal muscle mitochondrial dysfunction mediated by Pseudomonas aeruginosa quorum-sensing transcription factor MvfR: reversing effects with anti-MvfR and mitochondrial-targeted compounds.
Aggarwal S · mBio · 2024
Animal study (in vivo) · mouse · 1 result
- Mitochondria-targeted reactive oxygen species blockor SS-31 blocks hepatic stellate cell activation and alleviates hepatic fibrosis by regulating NLRP3 inflammasomes.
Liu L · Cellular and molecular biology (Noisy-le-Grand, France) · 2024
Animal study (in vivo) · mouse · 10 results
- Elamipretide effects on the skeletal muscle phosphoproteome in aged female mice.
Campbell MD · GeroScience · 2022
Animal study (in vivo) · mouse · 1 result
- SS-31 ameliorates hepatic injury in rats subjected to severe burns plus delayed resuscitation via inhibiting the mtDNA/STING pathway in Kupffer cells.
Wu Y · Biochemical and biophysical research communications · 2021
Animal study (in vivo) · rat · 6 results
- [Protective effect of mitochondria-targeted antioxidant peptide SS-31 in sepsis-induced acute kidney injury].
Sun M · Zhonghua wei zhong bing ji jiu yi xue · 2021
Animal study (in vivo) · mouse · 7 results
- Early treatment with combination of SS31 and entresto effectively preserved the heart function in doxorubicin-induced dilated cardiomyopathic rat.
Yeh JN · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021
Animal study (in vivo) · rat · 9 results
- Arsenic Directs Stem Cell Fate by Imparting Notch Signaling Into the Extracellular Matrix Niche.
Anguiano T · Toxicological sciences : an official journal of the Society of Toxicology · 2020
Animal study (in vivo) · mouse · 3 results
- Protective effect of the antioxidative peptide SS31 on ionizing radiation-induced hematopoietic system damage in mice.
Han X · Blood cells, molecules & diseases · 2019
Animal study (in vivo) · mouse · 9 results
- Mitochondrial Cardiolipin-Targeted Tetrapeptide, SS-31, Exerts Neuroprotective Effects Within In Vitro and In Vivo Models of Spinal Cord Injury.
Ravenscraft B · International journal of molecular sciences · 2025
Animal study (in vivo) · mouse · 6 results
- Role of AQP3 in the Vascular Leakage of Sepsis and the Protective Effect of Ss-31.
Zhang J · Journal of cardiovascular pharmacology · 2021
Animal study (in vivo) · rat · 4 results
- Effects of Elamipretide on Autophagy in Renal Cells of Pigs with Metabolic Syndrome.
Hong S · Cells · 2022
Animal study (in vivo) · pig · 5 results
- SS31 Ameliorates Oxidative Stress via the Restoration of Autophagic Flux to Protect Aged Mice From Hind Limb Ischemia.
Yang Q · Frontiers in cardiovascular medicine · 2022
Animal study (in vivo) · mouse · 11 results
- A 50 kdyne contusion spinal cord injury with or without the drug SS-31 was not associated with major changes in muscle mass or gene expression 14 d after injury in young male mice.
Graham ZA · Physiological reports · 2021
Animal study (in vivo) · mouse · 5 results
- A mitochondrial targeting tetrapeptide Bendavia protects lateral line hair cells from gentamicin exposure.
Kuang X · Journal of applied toxicology : JAT · 2018
Animal study (in vivo) · zebrafish · 3 results
- YTHDF1-mediated mitochondrial dysfunction and allergic airway inflammation by interaction with β-catenin/TCF4 signaling.
Xie C · International immunopharmacology · 2025
Animal study (in vivo) · mouse · 2 results
- Intermittent treatment with elamipretide preserves exercise tolerance in aged female mice.
Campbell MD · GeroScience · 2023
Animal study (in vivo) · mouse · 5 results
- Aging Increases Susceptibility to Develop Cardiac Hypertrophy following High Sugar Consumption.
Valencia AP · Nutrients · 2022
Animal study (in vivo) · mouse · 3 results
- Mitochondrial dysfunction drives age-related degeneration of the thoracic aorta.
Dhanekula AS · GeroScience · 2026
Animal study (in vivo) · mouse · 5 results
- SS-31 improves post-cardiac arrest brain injury by inhibiting microglial ferroptosis and polarization.
Jiang T · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
Animal study (in vivo) · rat · 11 results
- Acute mitochondrial reactive oxygen species emissions drive mitochondrial dysfunction after traumatic muscle injury in male mice.
Heo J · American journal of physiology. Cell physiology · 2025
Animal study (in vivo) · mouse · 6 results
- Mitochondrial Targeting by Elamipretide Improves Myocardial Bioenergetics Without Translating into Functional Benefits in HFpEF.
Schauer A · International journal of molecular sciences · 2026
Animal study (in vivo) · rat · 15 results
- Elamipretide Improves Mitochondrial Function in Mitochondrial Trifunctional Protein-Deficient Mice and Human Fibroblasts.
Vieira Neto E · Journal of inherited metabolic disease · 2026
Animal study (in vivo) · mouse · 7 results
- SS-31: A promising therapeutic agent against bleomycin-induced pulmonary fibrosis in Mice.
Gu Q · PloS one · 2025
Animal study (in vivo) · mouse · 9 results
- Protective effects of SS-31 against SDHB suppression-mitochondrial dysfunction-EndMT axis-modulated CBT sclerosis and progression.
Tang H · American journal of translational research · 2020
Animal study (in vivo) · mouse · 5 results
- Szeto-Schiller 31 eases acute lung injury in neonatal mice with acute respiratory distress syndrome by mediating TXNIP expression and NLRP3 inflammasome activation.
Zhu M · Translational pediatrics · 2025
Animal study (in vivo) · mouse · 13 results
- [Protective effect of mitochondria-targeted antioxidant SS31 on early brain injury following subarachnoid hemorrhage in rats].
Zhou J · Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2017
Animal study (in vivo) · rat · 9 results
- Elamipretide (SS-31) promotes recovery by preserving mitochondrial bioenergetics and neural remodeling after spinal cord injury.
Song Z · Neurochemistry international · 2026
Animal study (in vivo) · mouse · 12 results
- Breaking a mitochondrial danger-STING feed-forward amplifier preserves alveolar-capillary architecture and dampens interferon-chemokine signaling in acute lung injury.
Elmorsy EA · Tissue & cell · 2026
Animal study (in vivo) · 6 results