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Study · Animal study (in vivo) · mouse · 2019

4 results

AGED MICE ARE SUSCEPTIBLE TO CARDIAC HYPERTROPHY AFTER 1 WEEK OF CONSUMING A HIGH SUGAR DIET

Valencia A, Whitson J, Stuppard R, Valencia G, Rabinovitch P, Marcinek D

Innovation in aging1 Nov 2019

PMCIDPMC6844926 (opens in a new tab)PepBankPUB-97542098
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Summary

Abstract Over 80% of American adults exceed their daily recommended intake of sugar (<10% kcal). While habitual sugar consumption is associated with an increased risk for diabetes and cardiovascular disease, less is known about the effects of short-term sugar consumption on metabolic health, particularly in the elderly. The purpose of this study was to test whether aged hearts are more susceptible to pathology following a short-term high sucrose (HS) diet. Specific goals were to: A) determine the effects of a 1-week HS diet exposure on the hearts of 5 month-old and 24 month-old mice; and B) test if the mitochondrial targeted peptide SS-31 can protect against HS-diet induced effects. Male CB6F1 mice were placed either on standard chow or HS diet after 1 week of receiving saline (control) or SS-31 through osmotic pumps. Heart function was assessed in vivo through echocardiography before and after treatments. One week of HS induced significant cardiac hypertrophy in the old mice compared to age-matched chow controls. Treatment with SS-31 prevented this HS induced hypertrophy. Young hearts were smaller than in the old, but size was unaffected by diet or SS-31. We observed no effect of HS (with or without SS-31) on respiration or H2O2 production in isolated mitochondria from hearts using high-resolution respirometry. These data indicate that only 1-week exposure to HS diet is enough to exacerbate cardiac hypertrophy in aging mice, but factors other than heart mitochondrial ROS may mediate this effect.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aged mice on a 1-week high sucrose diet, SS‑31 prevented diet-induced cardiac hypertrophy.

    In plain wordsIn old mice on a high sugar diet, SS‑31 prevented heart enlargement.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCardiac hypertrophy after 1 week high sucrose diet in old mice
    Study

    mousen: not reported in source

    Male CB6F1 mice on high sucrose diet
    Comparator
    Saline
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · osmotic pumpAs given in this study (mouse).

    Source sentences

    Summary
    Treatment with SS-31 prevented this HS induced hypertrophy.
    2 context sentences
    Summary · context
    One week of HS induced significant cardiac hypertrophy in the old mice compared to age-matched chow controls.
    Summary · context
    Male CB6F1 mice were placed either on standard chow or HS diet after 1 week of receiving saline (control) or SS-31 through osmotic pumps.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In young mice, heart size was not affected by diet or SS‑31.

    In plain wordsIn young mice, heart size did not change with diet or SS‑31.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeHeart size in young mice
    Study

    mousen: not reported in source

    Male CB6F1 mice on high sucrose diet
    Comparator
    Saline
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · osmotic pumpAs given in this study (mouse).

    Source sentences

    Summary
    Young hearts were smaller than in the old, but size was unaffected by diet or SS-31.
    1 context sentence
    Summary · context
    Male CB6F1 mice were placed either on standard chow or HS diet after 1 week of receiving saline (control) or SS-31 through osmotic pumps.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, a high sucrose diet, with or without SS‑31, had no effect on respiration of isolated heart mitochondria.

    In plain wordsIn mice, a high sugar diet, with or without SS‑31, did not change oxygen use in isolated heart mitochondria.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeMitochondrial respiration in isolated heart mitochondria
    Study

    mousen: not reported in source

    Male CB6F1 mice on high sucrose diet
    Comparator
    Saline
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated · osmotic pumpAs given in this study (mouse).

    Source sentences

    Summary
    We observed no effect of HS (with or without SS-31) on respiration
    1 context sentence
    Summary · context
    Male CB6F1 mice were placed either on standard chow or HS diet after 1 week of receiving saline (control) or SS-31 through osmotic pumps.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice, a high sucrose diet, with or without SS‑31, had no effect on H2O2 production in isolated heart mitochondria.

    In plain wordsIn mice, a high sugar diet, with or without SS‑31, did not change hydrogen peroxide production in isolated heart mitochondria.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeH2O2 production in isolated heart mitochondria
    Study

    mousen: not reported in source

    Male CB6F1 mice on high sucrose diet
    Comparator
    Saline
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated · osmotic pumpAs given in this study (mouse).

    Source sentences

    Summary
    We observed no effect of HS (with or without SS-31) on respiration or H2O2 production in isolated mitochondria from hearts
    1 context sentence
    Summary · context
    Male CB6F1 mice were placed either on standard chow or HS diet after 1 week of receiving saline (control) or SS-31 through osmotic pumps.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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