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Study · Ex vivo tissue · mouse · 2024

8 results

Effect of Elamipretide on the Vitrification of Mouse Ovarian Tissue by Freezing.

Yao X, Lu Q, Wu Y, Liu J, Liu N, Huang X, Xu C

Biopreservation and biobanking22 Apr 2024Cited by 7 (Europe PMC)

PMID38648553 (opens in a new tab)PMCIDPMC11656123 (opens in a new tab)DOI10.1089/bio.2023.0078 (opens in a new tab)PepBankPUB-38648553
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In vitrified mouse ovarian tissue, 100 umol/L SS‑31 significantly improved follicle quality.

    In plain wordsIn lab-tested mouse ovarian tissue after freezing, SS‑31 improved the quality of egg follicles.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseFollicle quality
    Study

    mousen: not reported in source

    Vitrified mouse ovarian tissue
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 μmol/L · added to cryoprotectant resuscitation solutionAs given in this study (mouse).

    Source sentences

    Summary
    At the end of the experiment, the addition of 100 μmol/L SS-31 significantly improved follicle quality and oocyte maturation rate in vitro (p p p < 0.05).
    1 context sentence
    Summary · context
    In this study, we examined follicular morphology and viability, mitochondrial function and oxidative stress levels, apoptosis, and culture in vitro after vitrification cryoresuscitation operation by treating ovarian tissues with SS-31 in cryoprotectant resuscitation solution.
  2. 02LabEx vivo tissueEfficacy outcome

    In vitrified mouse ovarian tissue, 100 umol/L SS‑31 significantly improved the oocyte maturation rate in vitro.

    In plain wordsIn lab-tested mouse ovarian tissue after freezing, SS‑31 raised the share of eggs that matured in culture.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseIn vitro oocyte maturation rate
    Study

    mousen: not reported in source

    Vitrified mouse ovarian tissue
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 μmol/L · added to cryoprotectant resuscitation solutionAs given in this study (mouse).

    Source sentences

    Summary
    At the end of the experiment, the addition of 100 μmol/L SS-31 significantly improved follicle quality and oocyte maturation rate in vitro (p p p < 0.05).
    1 context sentence
    Summary · context
    In this study, we examined follicular morphology and viability, mitochondrial function and oxidative stress levels, apoptosis, and culture in vitro after vitrification cryoresuscitation operation by treating ovarian tissues with SS-31 in cryoprotectant resuscitation solution.
  3. 03LabEx vivo tissueEfficacy outcome

    In vitrified mouse ovarian tissue, 100 umol/L SS‑31 significantly reduced apoptosis.

    In plain wordsIn lab-tested mouse ovarian tissue after freezing, SS‑31 reduced programmed cell death.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseApoptosis
    Study

    mousen: not reported in source

    Vitrified mouse ovarian tissue
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 μmol/L · added to cryoprotectant resuscitation solutionAs given in this study (mouse).

    Source sentences

    Summary
    At the end of the experiment, the addition of 100 μmol/L SS-31 significantly improved follicle quality and oocyte maturation rate in vitro (p p p < 0.05).
    1 context sentence
    Summary · context
    In this study, we examined follicular morphology and viability, mitochondrial function and oxidative stress levels, apoptosis, and culture in vitro after vitrification cryoresuscitation operation by treating ovarian tissues with SS-31 in cryoprotectant resuscitation solution.
  4. 04LabEx vivo tissueEfficacy outcome

    In vitrified mouse ovarian tissue, 100 umol/L SS‑31 significantly reduced oxidative stress levels (superoxide dismutase, catalase, malondialdehyde).

    In plain wordsIn lab-tested mouse ovarian tissue after freezing, SS‑31 reduced oxidative stress.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseOxidative stress levels (SOD, catalase, malondialdehyde)
    Study

    mousen: not reported in source

    Vitrified mouse ovarian tissue
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    100 μmol/L · added to cryoprotectant resuscitation solutionAs given in this study (mouse).

    Source sentences

    Summary
    At the end of the experiment, the addition of 100 μmol/L SS-31 significantly improved follicle quality and oocyte maturation rate in vitro (p p p < 0.05).
    1 context sentence
    Summary · context
    In this study, we examined follicular morphology and viability, mitochondrial function and oxidative stress levels, apoptosis, and culture in vitro after vitrification cryoresuscitation operation by treating ovarian tissues with SS-31 in cryoprotectant resuscitation solution.
  5. 05LabEx vivo tissueEfficacy outcome

    In vitrified mouse ovarian tissue, mitochondrial respiratory chain complex enzyme activity was significantly increased in the 100 umol/L SS‑31 group.

    In plain wordsIn lab-tested mouse ovarian tissue after freezing, SS‑31 raised the activity of mitochondrial energy enzymes.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial respiratory chain complex enzyme activity
    Study

    mousen: not reported in source

    Vitrified mouse ovarian tissue
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    100 μmol/L · added to cryoprotectant resuscitation solutionAs given in this study (mouse).

    Source sentences

    Summary
    Meanwhile, mitochondrial respiratory chain complex enzyme activity, mtDNA copy number (p p < 0.05) content were significantly increased in the 100 μmol/L SS-31-treated group.
    1 context sentence
    Summary · context
    In this study, we examined follicular morphology and viability, mitochondrial function and oxidative stress levels, apoptosis, and culture in vitro after vitrification cryoresuscitation operation by treating ovarian tissues with SS-31 in cryoprotectant resuscitation solution.
  6. 06LabEx vivo tissueEfficacy outcome

    In vitrified mouse ovarian tissue, mtDNA copy number was significantly increased in the 100 umol/L SS‑31 group.

    In plain wordsIn lab-tested mouse ovarian tissue after freezing, SS‑31 raised the number of mitochondrial DNA copies.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreasemtDNA copy number
    Study

    mousen: not reported in source

    Vitrified mouse ovarian tissue
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    100 μmol/L · added to cryoprotectant resuscitation solutionAs given in this study (mouse).

    Source sentences

    Summary
    Meanwhile, mitochondrial respiratory chain complex enzyme activity, mtDNA copy number (p p < 0.05) content were significantly increased in the 100 μmol/L SS-31-treated group.
    1 context sentence
    Summary · context
    In this study, we examined follicular morphology and viability, mitochondrial function and oxidative stress levels, apoptosis, and culture in vitro after vitrification cryoresuscitation operation by treating ovarian tissues with SS-31 in cryoprotectant resuscitation solution.
  7. 07LabEx vivo tissueEfficacy outcome

    In vitrified mouse ovarian tissue, ATP content was significantly increased in the 100 umol/L SS‑31 group.

    In plain wordsIn lab-tested mouse ovarian tissue after freezing, SS‑31 raised the energy molecule ATP.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseATP content
    Study

    mousen: not reported in source

    Vitrified mouse ovarian tissue
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    100 μmol/L · added to cryoprotectant resuscitation solutionAs given in this study (mouse).

    Source sentences

    Summary
    Meanwhile, mitochondrial respiratory chain complex enzyme activity, mtDNA copy number (p p < 0.05) content were significantly increased in the 100 μmol/L SS-31-treated group.
    1 context sentence
    Summary · context
    In this study, we examined follicular morphology and viability, mitochondrial function and oxidative stress levels, apoptosis, and culture in vitro after vitrification cryoresuscitation operation by treating ovarian tissues with SS-31 in cryoprotectant resuscitation solution.
  8. 08LabEx vivo tissueEfficacy outcome

    In vitrified mouse ovarian tissue, mRNA levels of mitochondrial energy metabolism and biosynthesis genes (STRT1, PGC-1a, PPAR-a, TFAM) were markedly upregulated in the 100 umol/L SS‑31 group.

    In plain wordsIn lab-tested mouse ovarian tissue after freezing, SS‑31 raised the activity of genes for mitochondrial energy production.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseExpression of mitochondrial energy metabolism and biosynthesis genes
    Study

    mousen: not reported in source

    Vitrified mouse ovarian tissue
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    100 μmol/L · added to cryoprotectant resuscitation solutionAs given in this study (mouse).

    Source sentences

    Summary
    In addition, the mRNA expression levels of mitochondrial energy metabolism- and biosynthesis-related genes (STRT1, PGC-1a, PPAR-a, TFAM, p p < 0.05) in the 100 μmol/L SS-31 group.
    1 context sentence
    Summary · context
    In this study, we examined follicular morphology and viability, mitochondrial function and oxidative stress levels, apoptosis, and culture in vitro after vitrification cryoresuscitation operation by treating ovarian tissues with SS-31 in cryoprotectant resuscitation solution.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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