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Study · Other design · 2026

6 results

Dual action of SS31 via NRF2/HO-1: countering oxidative stress and metabolic dysfunction in ovarian aging.

Zhang G, Du X, Zhao Y, Zhi W, Wang L, Bai X, He L, Xie H, Liu J, Han C, Liu W

Journal of ovarian research17 Mar 2026Cited by 1 (Europe PMC)

PMID41840657 (opens in a new tab)PMCIDPMC13107672 (opens in a new tab)DOI10.1186/s13048-026-02076-z (opens in a new tab)PepBankPUB-41840657
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalOther designMechanism

    SS31 localized specifically to granulosa cell mitochondria.

    In plain wordsIn the ovary model, SS31 went specifically to the energy units (mitochondria) of granulosa cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Not applicableSubcellular localization of SS31
    Study

    n: not reported in source

    Aged ICR mice and D-galactose-treated KGN human granulosa cells
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS31 specifically localized to granulosa cell mitochondria.
    1 context sentence
    Summary · context
    This preclinical study utilized a naturally aged (10-month-old) female ICR mouse model and a D-galactose-induced senescence model in human KGN granulosa cells.
  2. 02AnimalOther designMechanism

    SS31 treatment alleviated oxidative damage-induced apoptosis in the ovarian aging models.

    In plain wordsIn the ovarian aging models, SS31 reduced cell death caused by oxidative damage.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseOxidative damage-induced apoptosis
    Study

    n: not reported in source

    Aged ICR mice and D-galactose-treated KGN human granulosa cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment alleviated oxidative damage-induced apoptosis
    1 context sentence
    Summary · context
    This preclinical study utilized a naturally aged (10-month-old) female ICR mouse model and a D-galactose-induced senescence model in human KGN granulosa cells.
  3. 03AnimalOther designMechanism

    SS31 treatment improved mitochondrial membrane potential in the ovarian aging models.

    In plain wordsIn the ovarian aging models, SS31 improved the electrical charge across mitochondrial membranes, a sign of healthier mitochondria.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial membrane potential
    Study

    n: not reported in source

    Aged ICR mice and D-galactose-treated KGN human granulosa cells
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    improved mitochondrial function (including membrane potential and ATP production), and ameliorated senescence-associated impairment of the granulosa cell-oocyte unit.
    1 context sentence
    Summary · context
    This preclinical study utilized a naturally aged (10-month-old) female ICR mouse model and a D-galactose-induced senescence model in human KGN granulosa cells.
  4. 04AnimalOther designMechanism

    SS31 treatment improved ATP production in the ovarian aging models.

    In plain wordsIn the ovarian aging models, SS31 improved the cells' production of ATP, their energy molecule.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial ATP production
    Study

    n: not reported in source

    Aged ICR mice and D-galactose-treated KGN human granulosa cells
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    improved mitochondrial function (including membrane potential and ATP production), and ameliorated senescence-associated impairment of the granulosa cell-oocyte unit.
    1 context sentence
    Summary · context
    This preclinical study utilized a naturally aged (10-month-old) female ICR mouse model and a D-galactose-induced senescence model in human KGN granulosa cells.
  5. 05AnimalOther designEfficacy outcome

    SS31 treatment ameliorated senescence-associated impairment of the granulosa cell-oocyte unit.

    In plain wordsIn the ovarian aging models, SS31 reduced age-related damage to the unit formed by egg cells and their support cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseSenescence-associated impairment of the granulosa cell-oocyte unit
    Study

    n: not reported in source

    Aged ICR mice and D-galactose-treated KGN human granulosa cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ameliorated senescence-associated impairment of the granulosa cell-oocyte unit.
    1 context sentence
    Summary · context
    This preclinical study utilized a naturally aged (10-month-old) female ICR mouse model and a D-galactose-induced senescence model in human KGN granulosa cells.
  6. 06AnimalOther designMechanism

    SS31 enhanced cellular antioxidant capacity by activating the NRF2/HO-1 signaling pathway.

    In plain wordsIn the ovarian aging models, SS31 switched on the NRF2/HO-1 pathway, which raises the cell's antioxidant defence.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseNRF2/HO-1 pathway activation
    Study

    n: not reported in source

    Aged ICR mice and D-galactose-treated KGN human granulosa cells
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, SS31 enhanced cellular antioxidant capacity by activating the NRF2/HO-1 signaling pathway.
    1 context sentence
    Summary · context
    This preclinical study utilized a naturally aged (10-month-old) female ICR mouse model and a D-galactose-induced senescence model in human KGN granulosa cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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