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Study · Animal study (in vivo) · rat · 2025

3 results

Endothelial Glycocalyx Degradation as a Mediator of Neuroinflammation and Cognitive Impairment in Aged Rats: Protective Role of SS-31.

Kan MH, Liu Y, Meng FQ, Fan L, Wu Y, Wang TL

Molecular neurobiology17 Nov 2025

PMID41247543 (opens in a new tab)DOI10.1007/s12035-025-05413-3 (opens in a new tab)PepBankPUB-41247543
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aged rats given LPS, SS‑31 pretreatment attenuated endothelial glycocalyx degradation.

    In plain wordsIn aged rats given LPS, SS‑31 before the LPS reduced damage to the lining of blood vessels.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseEndothelial glycocalyx degradation
    Study

    ratn: not reported in source

    aged rats with LPS-induced systemic inflammation
    Comparator
    LPS group
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 pretreatment attenuated eGC degradation
    2 context sentences
    Summary · context
    Aged male Wistar rats (24 months) were assigned to four groups: Vehicle, LPS, LPS + SS-31, and SS-31 alone.
    Summary · context
    SS-31 was administered 30 min prior to LPS injection in the LPS + SS-31 group.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In aged rats given LPS, SS‑31 pretreatment reduced neuroinflammation.

    In plain wordsIn aged rats given LPS, SS‑31 before the LPS reduced brain inflammation.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseHippocampal neuroinflammation
    Study

    ratn: not reported in source

    aged rats with LPS-induced systemic inflammation
    Comparator
    LPS group
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 pretreatment attenuated eGC degradation, reduced neuroinflammation
    2 context sentences
    Summary · context
    Aged male Wistar rats (24 months) were assigned to four groups: Vehicle, LPS, LPS + SS-31, and SS-31 alone.
    Summary · context
    SS-31 was administered 30 min prior to LPS injection in the LPS + SS-31 group.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In aged rats given LPS, SS‑31 pretreatment restored hippocampal PSD-95 levels.

    In plain wordsIn aged rats given LPS, SS‑31 before the LPS restored levels of a brain synapse protein.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseHippocampal PSD-95
    Study

    ratn: not reported in source

    aged rats with LPS-induced systemic inflammation
    Comparator
    LPS group
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 pretreatment attenuated eGC degradation, reduced neuroinflammation, and restored PSD-95 levels
    2 context sentences
    Summary · context
    Aged male Wistar rats (24 months) were assigned to four groups: Vehicle, LPS, LPS + SS-31, and SS-31 alone.
    Summary · context
    SS-31 was administered 30 min prior to LPS injection in the LPS + SS-31 group.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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