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Study · In vitro (cells) · mouse · 2011

3 results

Mitochondrial production of reactive oxygen species contributes to the β-adrenergic stimulation of mouse cardiomycytes.

Andersson DC, Fauconnier J, Yamada T, Lacampagne A, Zhang SJ, Katz A, Westerblad H

The Journal of physiology28 Feb 2011Cited by 103 (Europe PMC)

PMID21486840 (opens in a new tab)DOI10.1113/jphysiol.2010.202838 (opens in a new tab)PepBankPUB-21486840
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In isolated mouse cardiomyocytes, SS31 diminished the isoproterenol-induced increase in Ca2+ transient amplitude.

    In plain wordsIn mouse heart muscle cells, SS31 reduced the rise in calcium signal caused by a stimulating drug.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseIsoproterenol-induced Ca2+ transient amplitude
    Study

    mousen: not reported in source

    Freshly isolated mouse cardiomyocytes stimulated with isoproterenol
    Comparator
    Isoproterenol without SS31
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ISO increased Ca2+ transient amplitude, contraction and L-type Ca2+ current densities (measured with whole-cell patch-clamp) in cardiomyocytes and these increases were diminished by application of the general antioxidant N-acetylcysteine (NAC) or the mitochondria-targeted antioxidant SS31.
    1 context sentence
    Summary · context
    Cytoplasmic Ca2+ transients, cell shortening and ROS production were measured in freshly isolated cardiomyocytes using confocal microscopy and fluorescent indicators.
  2. 02LabIn vitro (cells)Mechanism

    In isolated mouse cardiomyocytes, SS31 diminished the isoproterenol-induced increase in cell contraction.

    In plain wordsIn mouse heart muscle cells, SS31 reduced the rise in contraction caused by a stimulating drug.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseIsoproterenol-induced contraction
    Study

    mousen: not reported in source

    Freshly isolated mouse cardiomyocytes stimulated with isoproterenol
    Comparator
    Isoproterenol without SS31
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ISO increased Ca2+ transient amplitude, contraction and L-type Ca2+ current densities (measured with whole-cell patch-clamp) in cardiomyocytes and these increases were diminished by application of the general antioxidant N-acetylcysteine (NAC) or the mitochondria-targeted antioxidant SS31.
    1 context sentence
    Summary · context
    Cytoplasmic Ca2+ transients, cell shortening and ROS production were measured in freshly isolated cardiomyocytes using confocal microscopy and fluorescent indicators.
  3. 03LabIn vitro (cells)Mechanism

    In isolated mouse cardiomyocytes, SS31 diminished the isoproterenol-induced increase in L-type Ca2+ current densities.

    In plain wordsIn mouse heart muscle cells, SS31 reduced the rise in calcium current caused by a stimulating drug.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseIsoproterenol-induced L-type Ca2+ current density
    Study

    mousen: not reported in source

    Freshly isolated mouse cardiomyocytes stimulated with isoproterenol
    Comparator
    Isoproterenol without SS31
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ISO increased Ca2+ transient amplitude, contraction and L-type Ca2+ current densities (measured with whole-cell patch-clamp) in cardiomyocytes and these increases were diminished by application of the general antioxidant N-acetylcysteine (NAC) or the mitochondria-targeted antioxidant SS31.
    1 context sentence
    Summary · context
    Cytoplasmic Ca2+ transients, cell shortening and ROS production were measured in freshly isolated cardiomyocytes using confocal microscopy and fluorescent indicators.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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