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Study · In vitro (cells) · 2018

11 results

Synergistic Protective Effects of Mitochondrial Division Inhibitor 1 and Mitochondria-Targeted Small Peptide SS31 in Alzheimer's Disease.

Reddy PH, Manczak M, Yin X, Reddy AP

Journal of Alzheimer's disease : JAD1 Jan 2018Cited by 77 (Europe PMC)

PMID29400667 (opens in a new tab)PMCIDPMC5884714 (opens in a new tab)DOI10.3233/jad-170988 (opens in a new tab)PepBankPUB-29400667
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In mutant AβPP cells, SS31 significantly reduced Aβ40 levels.

    In plain wordsIn cells carrying a mutant Alzheimer's protein gene, SS31 lowered Aβ40 levels.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseAmyloid-β40 level
    Study

    n: not reported in source

    Mutant AβPP cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found significantly reduced levels of Aβ40 and Aβ42 in mutant AβPP cells treated with SS31, Mdivi1, and SS31+Mdivi1, and the reduction of Aβ42 levels were much higher in SS31+Mdivi1 treated cells than individual treatments of SS31 and Mdivi1.
    1 context sentence
    Summary · context
    Using biochemical methods, we assessed mitochondrial function by measuring the levels of hydrogen peroxide, lipid peroxidation, cytochrome c oxidase activity, mitochondrial ATP, and GTPase Drp1 enzymatic activity in mutant AβPP cells.
  2. 02LabIn vitro (cells)Mechanism

    In mutant AβPP cells, SS31 significantly reduced Aβ42 levels.

    In plain wordsIn cells carrying a mutant Alzheimer's protein gene, SS31 lowered Aβ42 levels.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseAmyloid-β42 level
    Study

    n: not reported in source

    Mutant AβPP cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found significantly reduced levels of Aβ40 and Aβ42 in mutant AβPP cells treated with SS31, Mdivi1, and SS31+Mdivi1, and the reduction of Aβ42 levels were much higher in SS31+Mdivi1 treated cells than individual treatments of SS31 and Mdivi1.
    1 context sentence
    Summary · context
    Using biochemical methods, we assessed mitochondrial function by measuring the levels of hydrogen peroxide, lipid peroxidation, cytochrome c oxidase activity, mitochondrial ATP, and GTPase Drp1 enzymatic activity in mutant AβPP cells.
  3. 03LabIn vitro (cells)Mechanism

    In mutant AβPP cells, the reduction of Aβ42 was greater with SS31 plus Mdivi1 than with SS31 alone or Mdivi1 alone.

    In plain wordsIn cells carrying a mutant Alzheimer's protein gene, SS31 together with Mdivi1 lowered Aβ42 more than SS31 alone or Mdivi1 alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseAmyloid-β42 level, SS31 plus Mdivi1 versus single treatments
    Study

    n: not reported in source

    Mutant AβPP cells
    Comparator
    SS31 alone and Mdivi1 alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the reduction of Aβ42 levels were much higher in SS31+Mdivi1 treated cells than individual treatments of SS31 and Mdivi1.
    1 context sentence
    Summary · context
    Using biochemical methods, we assessed mitochondrial function by measuring the levels of hydrogen peroxide, lipid peroxidation, cytochrome c oxidase activity, mitochondrial ATP, and GTPase Drp1 enzymatic activity in mutant AβPP cells.
  4. 04LabIn vitro (cells)Mechanism

    In mutant AβPP cells, SS31 significantly increased the mitochondrial DNA copy number.

    In plain wordsIn cells carrying a mutant Alzheimer's protein gene, SS31 raised the mitochondrial DNA copy number.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial DNA copy number
    Study

    n: not reported in source

    Mutant AβPP cells
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The levels of mtDNA copy number and cell survival were significantly increased in SS31, Mdivi1, and SS31+Mdivi1 treated mutant AβPP cells; however, the increased levels of mtDNA copy number and cell survival were much higher in SS31+Mdivi1 treated cells than individual treatments of SS31 and Mdivi1.
    1 context sentence
    Summary · context
    Using biochemical methods, we assessed mitochondrial function by measuring the levels of hydrogen peroxide, lipid peroxidation, cytochrome c oxidase activity, mitochondrial ATP, and GTPase Drp1 enzymatic activity in mutant AβPP cells.
  5. 05LabIn vitro (cells)Efficacy outcome

    In mutant AβPP cells, SS31 significantly increased cell survival.

    In plain wordsIn cells carrying a mutant Alzheimer's protein gene, SS31 increased cell survival.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseCell survival
    Study

    n: not reported in source

    Mutant AβPP cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The levels of mtDNA copy number and cell survival were significantly increased in SS31, Mdivi1, and SS31+Mdivi1 treated mutant AβPP cells; however, the increased levels of mtDNA copy number and cell survival were much higher in SS31+Mdivi1 treated cells than individual treatments of SS31 and Mdivi1.
    1 context sentence
    Summary · context
    Using biochemical methods, we assessed mitochondrial function by measuring the levels of hydrogen peroxide, lipid peroxidation, cytochrome c oxidase activity, mitochondrial ATP, and GTPase Drp1 enzymatic activity in mutant AβPP cells.
  6. 06LabIn vitro (cells)Mechanism

    In mutant AβPP cells, the increase in mitochondrial DNA copy number was greater with SS31 plus Mdivi1 than with SS31 alone or Mdivi1 alone.

    In plain wordsIn cells carrying a mutant Alzheimer's protein gene, SS31 together with Mdivi1 raised mitochondrial DNA copy number more than either one alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial DNA copy number, SS31 plus Mdivi1 versus single treatments
    Study

    n: not reported in source

    Mutant AβPP cells
    Comparator
    SS31 alone and Mdivi1 alone
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    however, the increased levels of mtDNA copy number and cell survival were much higher in SS31+Mdivi1 treated cells than individual treatments of SS31 and Mdivi1.
    1 context sentence
    Summary · context
    Using biochemical methods, we assessed mitochondrial function by measuring the levels of hydrogen peroxide, lipid peroxidation, cytochrome c oxidase activity, mitochondrial ATP, and GTPase Drp1 enzymatic activity in mutant AβPP cells.
  7. 07LabIn vitro (cells)Efficacy outcome

    In mutant AβPP cells, the increase in cell survival was greater with SS31 plus Mdivi1 than with SS31 alone or Mdivi1 alone.

    In plain wordsIn cells carrying a mutant Alzheimer's protein gene, SS31 together with Mdivi1 increased cell survival more than either one alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseCell survival, SS31 plus Mdivi1 versus single treatments
    Study

    n: not reported in source

    Mutant AβPP cells
    Comparator
    SS31 alone and Mdivi1 alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    however, the increased levels of mtDNA copy number and cell survival were much higher in SS31+Mdivi1 treated cells than individual treatments of SS31 and Mdivi1.
    1 context sentence
    Summary · context
    Using biochemical methods, we assessed mitochondrial function by measuring the levels of hydrogen peroxide, lipid peroxidation, cytochrome c oxidase activity, mitochondrial ATP, and GTPase Drp1 enzymatic activity in mutant AβPP cells.
  8. 08LabIn vitro (cells)Mechanism

    In mutant AβPP cells, SS31 significantly reduced mitochondrial dysfunction.

    In plain wordsIn cells carrying a mutant Alzheimer's protein gene, SS31 reduced mitochondrial dysfunction.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial dysfunction
    Study

    n: not reported in source

    Mutant AβPP cells
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mitochondrial dysfunction is significantly reduced in SS31, Mdivi1, and SS31+Mdivi1 treated mutant AβPP cells; however, the reduction is much higher in cells treated with both SS31+Mdvi1.
    1 context sentence
    Summary · context
    Using biochemical methods, we assessed mitochondrial function by measuring the levels of hydrogen peroxide, lipid peroxidation, cytochrome c oxidase activity, mitochondrial ATP, and GTPase Drp1 enzymatic activity in mutant AβPP cells.
  9. 09LabIn vitro (cells)Mechanism

    In mutant AβPP cells, the reduction in mitochondrial dysfunction was greater with SS31 plus Mdivi1 than with SS31 alone or Mdivi1 alone.

    In plain wordsIn cells carrying a mutant Alzheimer's protein gene, SS31 together with Mdivi1 reduced mitochondrial dysfunction more than either one alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial dysfunction, SS31 plus Mdivi1 versus single treatments
    Study

    n: not reported in source

    Mutant AβPP cells
    Comparator
    SS31 alone and Mdivi1 alone
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    however, the reduction is much higher in cells treated with both SS31+Mdvi1.
    1 context sentence
    Summary · context
    Using biochemical methods, we assessed mitochondrial function by measuring the levels of hydrogen peroxide, lipid peroxidation, cytochrome c oxidase activity, mitochondrial ATP, and GTPase Drp1 enzymatic activity in mutant AβPP cells.
  10. 10LabIn vitro (cells)Mechanism

    In mutant AβPP cells, SS31 reduced GTPase Drp1 activity.

    In plain wordsIn cells carrying a mutant Alzheimer's protein gene, SS31 reduced the activity of the enzyme Drp1.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseGTPase Drp1 activity
    Study

    n: not reported in source

    Mutant AβPP cells
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Similarly, GTPase Drp1 activity is reduced in all treatments, but reduced much higher in SS31+Mdivi1 treated cells.
    1 context sentence
    Summary · context
    Using biochemical methods, we assessed mitochondrial function by measuring the levels of hydrogen peroxide, lipid peroxidation, cytochrome c oxidase activity, mitochondrial ATP, and GTPase Drp1 enzymatic activity in mutant AβPP cells.
  11. 11LabIn vitro (cells)Mechanism

    In mutant AβPP cells, GTPase Drp1 activity was reduced more with SS31 plus Mdivi1 than with the single treatments.

    In plain wordsIn cells carrying a mutant Alzheimer's protein gene, SS31 together with Mdivi1 reduced Drp1 enzyme activity more than either one alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseGTPase Drp1 activity, SS31 plus Mdivi1 versus single treatments
    Study

    n: not reported in source

    Mutant AβPP cells
    Comparator
    SS31 alone and Mdivi1 alone
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but reduced much higher in SS31+Mdivi1 treated cells.
    1 context sentence
    Summary · context
    Using biochemical methods, we assessed mitochondrial function by measuring the levels of hydrogen peroxide, lipid peroxidation, cytochrome c oxidase activity, mitochondrial ATP, and GTPase Drp1 enzymatic activity in mutant AβPP cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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