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Study · Animal study (in vivo) · mouse · 2026

5 results

SS31 protects damaged retinal cells through the AMPK/DRP1 signaling pathway.

Cui N, Zhang RX, Yang Q, Ren Y, Jia J, Wang X, Liu X, He Y

Molecular vision5 Jul 2026

PMID42774068 (opens in a new tab)PMCIDPMC13568172 (opens in a new tab)DOI10.63500/mv_v32_265 (opens in a new tab)PepBankPUB-42774068
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute ocular hypertension, SS31 reduced intraocular pressure.

    In plain wordsIn mice with high eye pressure, SS31 lowered the eye pressure.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseIntraocular pressure
    Study

    mousen: not reported in source

    acute ocular hypertension
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS31 reduced intraocular pressure and maintained normal retinal thickness in mice with acute ocular hypertension.
    1 context sentence
    Summary · context
    In addition, intraocular pressure and retinal thickness were evaluated in mice with acute ocular hypertension.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute ocular hypertension, SS31 maintained normal retinal thickness.

    In plain wordsIn mice with high eye pressure, SS31 kept the retina at normal thickness.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeRetinal thickness
    Study

    mousen: not reported in source

    acute ocular hypertension
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS31 reduced intraocular pressure and maintained normal retinal thickness in mice with acute ocular hypertension.
    1 context sentence
    Summary · context
    In addition, intraocular pressure and retinal thickness were evaluated in mice with acute ocular hypertension.
  3. 03LabIn vitro (cells)Efficacy outcome

    In 661W retinal cells, SS31 pretreatment inhibited hydrogen peroxide-induced cell death through the AMPK signaling pathway.

    In plain wordsIn cells, SS31 reduced cell death caused by oxidative stress in retinal-type cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseHydrogen peroxide-induced cell death of 661W cells
    Study

    n: not reported in source

    661W cells
    Outcome group
    Neuroprotection · Eye
    Studied dose
    100 nM · 2 h pretreatmentAs given in this study.

    Source sentences

    Summary
    SS31 inhibited H2O2-induced cell death of 661W through the AMPK signaling pathway and maintained mitochondrial genetic stability.
    1 context sentence
    Summary · context
    The cells were inoculated in the well plate and treated with H2O2 (150 μM) for 24 h and pretreated with or without SS31 (100 nM), AICAR (17.5 μM), or dorsomorphin (7 μM) for 2 h.
  4. 04LabIn vitro (cells)Mechanism

    In 661W cells under hydrogen peroxide stress, SS31 maintained mitochondrial genetic stability.

    In plain wordsIn cells, SS31 helped keep mitochondrial DNA stable under oxidative stress.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Direction not reportedMitochondrial genetic stability
    Study

    n: not reported in source

    661W cells
    Outcome group
    Mitochondrial function · Eye
    Studied dose
    100 nM · 2 h pretreatmentAs given in this study.

    Source sentences

    Summary
    SS31 inhibited H2O2-induced cell death of 661W through the AMPK signaling pathway and maintained mitochondrial genetic stability.
    1 context sentence
    Summary · context
    Mitochondrial genetic stability was detected by droplet digital PCR.
  5. 05LabIn vitro (cells)Mechanism

    In 661W cells after oxidative stress, SS31 regulated AMPK/Drp1 signaling.

    In plain wordsIn cells, SS31 changed the AMPK and Drp1 signals after oxidative stress.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Direction not reportedAMPK/Drp1 signaling after oxidative stress
    Study

    n: not reported in source

    661W cells
    Outcome group
    Mitochondrial function · Eye
    Studied dose
    100 nM · 2 h pretreatmentAs given in this study.

    Source sentences

    Summary
    SS31 regulates AMPK/Drp1 signaling in 661W cells after oxidative stress.
    1 context sentence
    Summary · context
    The expression of AMPK and DRP1 was detected by western blot.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 12Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 9 times, first on 21 Oct 2026, 15:59 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    21 Oct 2026, 12:50 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    10 Oct 2026, 08:19 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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