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Study · Animal study (in vivo) · mouse · 2026

4 results

Seawater immersion reshapes the temporal dynamics of traumatic brain injury and reveals mitochondrial oxidative stress as a modifiable therapeutic target.

Li W, He R, Xie S, Li M, Liu J, Hao F, Cheng G, Zhang J

Experimental neurology14 Aug 2026

PMID42600764 (opens in a new tab)DOI10.1016/j.expneurol.2026.115979 (opens in a new tab)PepBankPUB-42600764
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with traumatic brain injury and seawater immersion, SS‑31 partially mitigated selected inflammatory abnormalities.

    In plain wordsIn mice with brain injury and seawater exposure, SS‑31 partly reduced some signs of inflammation.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Direction not reportedInflammatory abnormalities after seawater-immersed TBI
    Study

    mousen: not reported in source

    Controlled cortical impact with seawater immersion
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 partially mitigated selected inflammatory, redox, neuronal, and white matter abnormalities, supporting mitochondrial oxidative stress as a modifiable node rather than the sole driver of trajectory remodeling.
    1 context sentence
    Summary · context
    Here, we applied time-resolved proteomics to mouse brains after controlled cortical impact (CCI) with or without artificial SW immersion at 1, 3, 7, and 28 days post-injury.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with traumatic brain injury and seawater immersion, SS‑31 partially mitigated selected redox abnormalities.

    In plain wordsIn mice with brain injury and seawater exposure, SS‑31 partly reduced some signs of oxidative imbalance.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Direction not reportedRedox abnormalities after seawater-immersed TBI
    Study

    mousen: not reported in source

    Controlled cortical impact with seawater immersion
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 partially mitigated selected inflammatory, redox, neuronal, and white matter abnormalities, supporting mitochondrial oxidative stress as a modifiable node rather than the sole driver of trajectory remodeling.
    1 context sentence
    Summary · context
    Here, we applied time-resolved proteomics to mouse brains after controlled cortical impact (CCI) with or without artificial SW immersion at 1, 3, 7, and 28 days post-injury.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with traumatic brain injury and seawater immersion, SS‑31 partially mitigated selected neuronal abnormalities.

    In plain wordsIn mice with brain injury and seawater exposure, SS‑31 partly reduced some nerve cell damage.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Direction not reportedNeuronal abnormalities after seawater-immersed TBI
    Study

    mousen: not reported in source

    Controlled cortical impact with seawater immersion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 partially mitigated selected inflammatory, redox, neuronal, and white matter abnormalities, supporting mitochondrial oxidative stress as a modifiable node rather than the sole driver of trajectory remodeling.
    1 context sentence
    Summary · context
    Here, we applied time-resolved proteomics to mouse brains after controlled cortical impact (CCI) with or without artificial SW immersion at 1, 3, 7, and 28 days post-injury.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with traumatic brain injury and seawater immersion, SS‑31 partially mitigated selected white matter abnormalities.

    In plain wordsIn mice with brain injury and seawater exposure, SS‑31 partly reduced some damage to brain white matter.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Direction not reportedWhite matter abnormalities after seawater-immersed TBI
    Study

    mousen: not reported in source

    Controlled cortical impact with seawater immersion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 partially mitigated selected inflammatory, redox, neuronal, and white matter abnormalities, supporting mitochondrial oxidative stress as a modifiable node rather than the sole driver of trajectory remodeling.
    1 context sentence
    Summary · context
    Here, we applied time-resolved proteomics to mouse brains after controlled cortical impact (CCI) with or without artificial SW immersion at 1, 3, 7, and 28 days post-injury.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

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