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Study · Animal study (in vivo) · 2024

4 results

Mitochondrial oxidative damage reprograms lipid metabolism of renal tubular epithelial cells in the diabetic kidney

Hou Y, Tan E, Shi H, Ren X, Wan X, Wu W, Chen Y, Niu H, Zhu G, Li J, Li Y, Wang L

Cell. Mol. Life Sci1 Dec 2024

PepBankPUB-91656577
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Summary

The text of this summary is not shown here, because the article license does not allow reuse.

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In diabetic kidney disease, SS31 reversed the decreased expression of key fatty acid oxidation enzymes and regulators.

    In plain wordsIn a diabetic kidney model, SS31 reversed the drop in key fat-burning enzymes.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseExpression of fatty acid oxidation enzymes and regulators
    Study

    n: not reported in source

    Diabetic kidney disease
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mitochondria protected using SS31 significantly reversed the decreased expression of key enzymes and regulators of fatty acid oxidation (FAO)
    1 context sentence
    Summary · context
    Using SS31, a tetrapeptide that protects the mitochondrial cristae structure, we demonstrated that mitochondrial oxidative damage contributes to TEC injury and lipid peroxidation caused by lipid accumulation.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In diabetic kidney disease, SS31 had no obvious effect on major glucose metabolic rate-limiting enzymes.

    In plain wordsIn a diabetic kidney model, SS31 had no obvious effect on the main enzymes that control glucose use.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeGlucose metabolic rate-limiting enzymes
    Study

    n: not reported in source

    Diabetic kidney disease
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    but had no obvious effect on major glucose metabolic rate-limiting enzymes.
    1 context sentence
    Summary · context
    Using SS31, a tetrapeptide that protects the mitochondrial cristae structure, we demonstrated that mitochondrial oxidative damage contributes to TEC injury and lipid peroxidation caused by lipid accumulation.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In diabetic kidney disease, SS31 limited the elevated activity of Acer1, S1pr1 and SPHK1.

    In plain wordsIn a diabetic kidney model, SS31 limited the raised activity of three enzymes and receptors in the S1P pathway.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseAcer1, S1pr1 and SPHK1 activity
    Study

    n: not reported in source

    Diabetic kidney disease
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS31 limited the elevated Acer1, S1pr1 and SPHK1 activity
    1 context sentence
    Summary · context
    Using SS31, a tetrapeptide that protects the mitochondrial cristae structure, we demonstrated that mitochondrial oxidative damage contributes to TEC injury and lipid peroxidation caused by lipid accumulation.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In diabetic kidney disease, SS31 limited the decrease in Spns2 expression.

    In plain wordsIn a diabetic kidney model, SS31 limited the drop in Spns2 expression.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseSpns2 expression
    Study

    n: not reported in source

    Diabetic kidney disease
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS31 limited the elevated Acer1, S1pr1 and SPHK1 activity, and the decreased Spns2 expression.
    1 context sentence
    Summary · context
    Using SS31, a tetrapeptide that protects the mitochondrial cristae structure, we demonstrated that mitochondrial oxidative damage contributes to TEC injury and lipid peroxidation caused by lipid accumulation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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