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Study · In vitro (cells) · 2011

6 results

Mitochondria-targeted antioxidant peptide SS31 attenuates high glucose-induced injury on human retinal endothelial cells.

Li J, Chen X, Xiao W, Ma W, Li T, Huang J, Liu X, Liang X, Tang S, Luo Y

Biochemical and biophysical research communications4 Dec 2010Cited by 55 (Europe PMC)

PMID21134355 (opens in a new tab)DOI10.1016/j.bbrc.2010.11.122 (opens in a new tab)PepBankPUB-21134355
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In cultured human retinal endothelial cells, co-treatment with 100 nM SS31 protected the cells from high glucose-induced injury compared with high glucose alone.

    In plain wordsIn cells, SS31 protected human retinal cells from damage caused by high glucose, compared with high glucose alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseHREC survival under high glucose
    Study

    humann: not reported in source

    Human retinal endothelial cells (HRECs)
    Comparator
    30 mM glucose without SS31
    Outcome group
    Cell viability and death · Eye
    Studied dose
    100 nMAs given in this study (human).

    Source sentences

    Summary
    significantly protected HRECs from high glucose-induced injury
    1 context sentence
    Summary · context
    Cultured P3-P5 HRECs were divided into three groups: 5 mM glucose group, 30 mM glucose group and 30 mM glucose co-treated with 100 nM SS31 group.
  2. 02LabIn vitro (cells)Mechanism

    In high glucose-treated human retinal endothelial cells, 100 nM SS31 reduced mitochondrial ROS production compared with high glucose alone.

    In plain wordsIn cells, SS31 lowered harmful reactive oxygen molecules made in mitochondria under high glucose, compared with high glucose alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial ROS production
    Study

    humann: not reported in source

    Human retinal endothelial cells (HRECs)
    Comparator
    30 mM glucose without SS31
    Outcome group
    Mitochondrial function · Eye
    Studied dose
    100 nMAs given in this study (human).

    Source sentences

    Summary
    reduced the production of ROS in mitochondria
    1 context sentence
    Summary · context
    Cultured P3-P5 HRECs were divided into three groups: 5 mM glucose group, 30 mM glucose group and 30 mM glucose co-treated with 100 nM SS31 group.
  3. 03LabIn vitro (cells)Mechanism

    In high glucose-treated human retinal endothelial cells, 100 nM SS31 stabilized the mitochondrial membrane potential compared with high glucose alone.

    In plain wordsIn cells, SS31 kept the electrical balance of mitochondria stable under high glucose, compared with high glucose alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial membrane potential
    Study

    humann: not reported in source

    Human retinal endothelial cells (HRECs)
    Comparator
    30 mM glucose without SS31
    Outcome group
    Mitochondrial function · Eye
    Studied dose
    100 nMAs given in this study (human).

    Source sentences

    Summary
    stabilized ΔΨ(m)
    1 context sentence
    Summary · context
    Cultured P3-P5 HRECs were divided into three groups: 5 mM glucose group, 30 mM glucose group and 30 mM glucose co-treated with 100 nM SS31 group.
  4. 04LabIn vitro (cells)Mechanism

    In high glucose-treated human retinal endothelial cells, 100 nM SS31 decreased cytochrome c release from mitochondria to cytoplasm compared with high glucose alone.

    In plain wordsIn cells, SS31 reduced the leak of cytochrome c out of mitochondria under high glucose, compared with high glucose alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCytochrome c release from mitochondria
    Study

    humann: not reported in source

    Human retinal endothelial cells (HRECs)
    Comparator
    30 mM glucose without SS31
    Outcome group
    Cell viability and death · Eye
    Studied dose
    100 nMAs given in this study (human).

    Source sentences

    Summary
    decreased the release of cytochrome c from mitochondria to cytoplasm
    1 context sentence
    Summary · context
    Cultured P3-P5 HRECs were divided into three groups: 5 mM glucose group, 30 mM glucose group and 30 mM glucose co-treated with 100 nM SS31 group.
  5. 05LabIn vitro (cells)Mechanism

    In high glucose-treated human retinal endothelial cells, 100 nM SS31 decreased caspase-3 expression compared with high glucose alone.

    In plain wordsIn cells, SS31 lowered levels of the cell-death enzyme caspase-3 under high glucose, compared with high glucose alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCaspase-3 expression
    Study

    humann: not reported in source

    Human retinal endothelial cells (HRECs)
    Comparator
    30 mM glucose without SS31
    Outcome group
    Cell viability and death · Eye
    Studied dose
    100 nMAs given in this study (human).

    Source sentences

    Summary
    decreased the expression of caspase-3 and increased the expression of Trx-2 in high glucose-treated HRECs.
    1 context sentence
    Summary · context
    Cultured P3-P5 HRECs were divided into three groups: 5 mM glucose group, 30 mM glucose group and 30 mM glucose co-treated with 100 nM SS31 group.
  6. 06LabIn vitro (cells)Mechanism

    In high glucose-treated human retinal endothelial cells, 100 nM SS31 increased thioredoxin-2 (Trx-2) expression compared with high glucose alone.

    In plain wordsIn cells, SS31 raised levels of the protective protein Trx-2 under high glucose, compared with high glucose alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseThioredoxin-2 expression
    Study

    humann: not reported in source

    Human retinal endothelial cells (HRECs)
    Comparator
    30 mM glucose without SS31
    Outcome group
    Mitochondrial function · Eye
    Studied dose
    100 nMAs given in this study (human).

    Source sentences

    Summary
    increased the expression of Trx-2
    1 context sentence
    Summary · context
    Cultured P3-P5 HRECs were divided into three groups: 5 mM glucose group, 30 mM glucose group and 30 mM glucose co-treated with 100 nM SS31 group.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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