Elamipretide Improves Mitochondrial Function in the Failing Human Heart.

Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL

JACC. Basic to translational science29 Apr 2019Cited by 118 (Europe PMC)

PMID31061916PMCIDPMC6488757DOI10.1016/j.jacbts.2018.12.005PepBankPUB-31061916

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueMechanism
In failing human ventricular tissue treated ex vivo, elamipretide improved mitochondrial oxygen flux.
In plain wordsIn lab tests on failing human heart tissue, elamipretide improved how well mitochondria used oxygen.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseMitochondrial oxygen flux
Study
humann: not reported in source
Explanted failing human ventricular tissue
Outcome group
Mitochondrial function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Mitochondrial function was impaired in the failing human heart, and mitochondrial oxygen flux, CI and CIV activities, and supercomplex-associated CIV activity significantly improved in response to elamipretide treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Freshly explanted failing and nonfailing ventricular tissue from children and adults was treated with elamipretide.
Report a problemFND-3106191601
02LabEx vivo tissueMechanism
In failing human ventricular tissue treated ex vivo, elamipretide improved mitochondrial complex I activity.
In plain wordsIn lab tests on failing human heart tissue, elamipretide improved the activity of a key mitochondrial enzyme complex (complex I).
Peptide
Elamipretide (SS-31)
Outcome
IncreaseComplex I activity
Study
humann: not reported in source
Explanted failing human ventricular tissue
Outcome group
Mitochondrial function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Mitochondrial function was impaired in the failing human heart, and mitochondrial oxygen flux, CI and CIV activities, and supercomplex-associated CIV activity significantly improved in response to elamipretide treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Freshly explanted failing and nonfailing ventricular tissue from children and adults was treated with elamipretide.
Report a problemFND-3106191602
03LabEx vivo tissueMechanism
In failing human ventricular tissue treated ex vivo, elamipretide improved mitochondrial complex IV activity.
In plain wordsIn lab tests on failing human heart tissue, elamipretide improved the activity of a key mitochondrial enzyme complex (complex IV).
Peptide
Elamipretide (SS-31)
Outcome
IncreaseComplex IV activity
Study
humann: not reported in source
Explanted failing human ventricular tissue
Outcome group
Mitochondrial function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Mitochondrial function was impaired in the failing human heart, and mitochondrial oxygen flux, CI and CIV activities, and supercomplex-associated CIV activity significantly improved in response to elamipretide treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Freshly explanted failing and nonfailing ventricular tissue from children and adults was treated with elamipretide.
Report a problemFND-3106191603
04LabEx vivo tissueMechanism
In failing human ventricular tissue treated ex vivo, elamipretide improved supercomplex-associated complex IV activity.
In plain wordsIn lab tests on failing human heart tissue, elamipretide improved complex IV activity inside mitochondrial supercomplexes.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseSupercomplex-associated complex IV activity
Study
humann: not reported in source
Explanted failing human ventricular tissue
Outcome group
Mitochondrial function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Mitochondrial function was impaired in the failing human heart, and mitochondrial oxygen flux, CI and CIV activities, and supercomplex-associated CIV activity significantly improved in response to elamipretide treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Freshly explanted failing and nonfailing ventricular tissue from children and adults was treated with elamipretide.
Report a problemFND-3106191604

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

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