Elamipretide (SS-31) studies: 372 papers with results
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- SS-31 Peptide Reverses the Mitochondrial Fragmentation Present in Fibroblasts From Patients With DCMA, a Mitochondrial Cardiomyopathy.
Machiraju P · Frontiers in cardiovascular medicine · 2019
In vitro (cells) · 3 results
- A20 attenuates pyroptosis and apoptosis in nucleus pulposus cells via promoting mitophagy and stabilizing mitochondrial dynamics.
Peng X · Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
In vitro (cells) · 2 results
- The mitochondrial antioxidant SS-31 attenuated lipopolysaccharide-induced apoptosis and pyroptosis of nucleus pulposus cells via scavenging mitochondrial ROS and maintaining the stability of mitochondrial dynamics.
Peng X · Free radical research · 2021
In vitro (cells) · 10 results
- Mitochondrion-Targeted Peptide SS-31 Inhibited Oxidized Low-Density Lipoproteins-Induced Foam Cell Formation through both ROS Scavenging and Inhibition of Cholesterol Influx in RAW264.7 Cells.
Hao S · Molecules (Basel, Switzerland) · 2015
In vitro (cells) · 9 results
- SS-31 attenuates TNF-α induced cytokine release from C2C12 myotubes.
Lightfoot AP · Redox biology · 2015
In vitro (cells) · mouse · 3 results
- Mitochondria-targeted antioxidant peptide SS31 prevents hypoxia/reoxygenation-induced apoptosis by down-regulating p66Shc in renal tubular epithelial cells.
Zhao WY · Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2013
In vitro (cells) · rat · 5 results
- ALCAT1-mediated abnormal cardiolipin remodelling promotes mitochondrial injury in podocytes in diabetic kidney disease.
Hao Y · Cell communication and signaling : CCS · 2024
In vitro (cells) · 3 results
- Mitochondria-targeted peptide MTP-131 alleviates mitochondrial dysfunction and oxidative damage in human trabecular meshwork cells.
Chen M · Investigative ophthalmology & visual science · 2011
In vitro (cells) · 7 results
- Do mitochondriotropic antioxidants prevent chlorinative stress-induced mitochondrial and cellular injury?
Whiteman M · Antioxidants & redox signaling · 2008
In vitro (cells) · 2 results
- Toxicity of neurons treated with herbicides and neuroprotection by mitochondria-targeted antioxidant SS31.
Reddy TP · International journal of environmental research and public health · 2011
In vitro (cells) · mouse · 1 result
- SS-31 reduces inflammation and oxidative stress through the inhibition of Fis1 expression in lipopolysaccharide-stimulated microglia.
Mo Y · Biochemical and biophysical research communications · 2019
In vitro (cells) · mouse · 4 results
- Mitochondria-targeted antioxidant attenuates high glucose-induced P38 MAPK pathway activation in human neuroblastoma cells.
Cao M · Molecular medicine reports · 2012
In vitro (cells) · 4 results
- Calcium-dependent phospholipase A2 modulates infection-induced diaphragm dysfunction.
Supinski GS · American journal of physiology. Lung cellular and molecular physiology · 2016
In vitro (cells) · mouse · 3 results
- Mitochondrial dysfunction and endoplasmic reticulum stress induced by activation of PPARα leaded testicular to apoptosis in SD rats explored to di-(2-ethylhexyl) phthalate (DEHP).
Zhang H · Ecotoxicology and environmental safety · 2023
In vitro (cells) · 1 result
- Mycophenolic Acid Induces the Intestinal Epithelial Barrier Damage through Mitochondrial ROS.
Deng Y · Oxidative medicine and cellular longevity · 2022
In vitro (cells) · 4 results
- Drp1-dependent peptide reverse mitochondrial fragmentation, a homeostatic response in Friedreich ataxia.
Johnson J · Pharmacology research & perspectives · 2021
In vitro (cells) · 3 results
- Mitochondria-Targeted Antioxidant Peptide SS31 Protects Cultured Human Lens Epithelial Cells against Oxidative Stress.
Cai M · Current eye research · 2015
In vitro (cells) · 5 results
- Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds.
Mitchell W · eLife · 2022
In vitro (cells) · 3 results
- Diverse mitochondrial abnormalities in a new cellular model of TAFFAZZIN deficiency are remediated by cardiolipin-interacting small molecules.
Anzmann AF · The Journal of biological chemistry · 2021
In vitro (cells) · 2 results
- Renovascular disease induces mitochondrial damage in swine scattered tubular cells.
Nargesi AA · American journal of physiology. Renal physiology · 2019
In vitro (cells) · pig · 4 results
- Recurrent non-severe hypoglycemia aggravates cognitive decline in diabetes and induces mitochondrial dysfunction in cultured astrocytes.
Gao R · Molecular and cellular endocrinology · 2021
In vitro (cells) · 2 results
- Protective effects of SS31 on t‑BHP induced oxidative damage in 661W cells.
Ma W · Molecular medicine reports · 2015
In vitro (cells) · 9 results
- SS-31 protect retinal pigment epithelial cells from H2 O2 -induced cell injury by reducing apoptosis.
Bai J · Clinical and experimental pharmacology & physiology · 2021
In vitro (cells) · 8 results
- Elamipretide Promotes Mitophagosome Formation and Prevents Its Reduction Induced by Nutrient Excess in INS1 β-cells.
Petcherski A · Journal of molecular biology · 2018
In vitro (cells) · 8 results
- Protective Effect of Bendavia (SS-31) Against Oxygen/Glucose-Deprivation Stress-Induced Mitochondrial Damage in Human Brain Microvascular Endothelial Cells.
Imai T · Current neurovascular research · 2017
In vitro (cells) · 3 results
- Doxycycline induces mitochondrial dysfunction in aortic smooth muscle cells.
Yap C · Vascular pharmacology · 2024
In vitro (cells) · 3 results
- SS-31 mitigates oxidative stress and restores mitochondrial function in cigarette smoke-damaged oral epithelial cells via PINK1-mediated mitophagy.
Ye P · Chemico-biological interactions · 2024
In vitro (cells) · 4 results
- SS-31 modification alleviates ferroptosis induced by superparamagnetic iron oxide nanoparticles in hypoxia/reoxygenation cardiomyocytes.
Lu Q · Heliyon · 2024
In vitro (cells) · 4 results
- Milk-derived exosome-loaded SS31 as a novel strategy to mitigate UV-induced photodamage in skin.
Luo D · Journal of photochemistry and photobiology. B, Biology · 2025
In vitro (cells) · 10 results
- The effects of a mitochondrial targeted peptide (elamipretide/SS31) on BAX recruitment and activation during apoptosis.
Grosser JA · BMC research notes · 2021
In vitro (cells) · 6 results
- Sirt6 deficiency exacerbates angiotensin II-induced lipid nephrotoxicity by affecting PLD6-derived cardiolipin metabolism in podocytes.
Hao Y · Cellular signalling · 2025
In vitro (cells) · 2 results
- Role of Mitochondrial ROS for Calcium Alternans in Atrial Myocytes.
Oropeza-Almazán Y · Biomolecules · 2024
In vitro (cells) · rabbit · 1 result
- SS-31 Targets NOS2 to Enhance Osteogenic Differentiation in Aged BMSCs by Restoring Mitochondrial Function.
Duan S · Organogenesis · 2025
In vitro (cells) · 6 results
- The mitochondrial dysfunction regulated by JAK2/STAT3 pathway leads to the necroptosis in the renal cells under patulin exposure.
Liu Y · Ecotoxicology and environmental safety · 2025
In vitro (cells) · 1 result
- The mitochondrial protectant SS31 optimized decellularized Wharton's jelly scaffold improves allogeneic chondrocyte implantation-mediated articular cartilage repair.
Wang C · Journal of orthopaedic translation · 2025
In vitro (cells) · 6 results
- SS-31 inhibits the inflammatory response by increasing ATG5 and promoting autophagy in lipopolysaccharide-stimulated HepG2 cells.
Mo Y · Biochemical and biophysical research communications · 2024
In vitro (cells) · 3 results
- Protective Effect of Mitochondrially Targeted Peptide Against Oxidant Injury of Cone Photoreceptors Through Preventing Necroptosis Pathway.
He Y · Journal of biomedical nanotechnology · 2021
In vitro (cells) · 4 results
- Mitochondrial-Targeted Protective Potential of Elamipretide for the In Vitro Production of Porcine Embryos.
Nguyen ST · Animals : an open access journal from MDPI · 2025
In vitro (cells) · pig · 6 results
- Blocking exosomal secretion aggravates 1,4-benzoquinone-induced mitochondrial fission activated by the AMPK/MFF/Drp1 pathway in HL-60 cells.
Lu F · Journal of applied toxicology : JAT · 2022
In vitro (cells) · 2 results
- Examination of mitochondria- and inflammasome-mediated mechanisms of clozapine-induced myocarditis using patient-derived iPSC cardiomyocytes.
Vaziri N · Molecular psychiatry · 2025
In vitro (cells) · 1 result
- Mitochondria-Targeted SS31-Conjugated Liposome Attenuates Oxidative Stress in Endothelial and Skeletal Muscle Cells.
Kim EM · Journal of vascular research · 2025
In vitro (cells) · 5 results
- The Mitochondrial-Targeted Peptide, SS31, Protects Murine 661W Cells from Oxidative Damage via Induction of Autophagy.
He Y · Journal of biomedical nanotechnology · 2020
In vitro (cells) · mouse · 5 results
- Mitochondrial-targeted SS-31 peptide attenuates radiation-induced cardiomyocyte senescence.
Xie L · Journal of radiation research · 2026
In vitro (cells) · rat · 9 results
- Mitochondrial-Targeted SS-31 Attenuates the Doxorubicin-Induced Cardiomyoblast H9C2 Cell Senescence.
Fan J · Biology · 2026
In vitro (cells) · rat · 7 results
- Therapeutic Peptide SS-31 Modulates Membrane Binding and Aggregation of α-Synuclein and Restores Impaired Mitochondrial Function.
Stefaniak E · Chemical biology & drug design · 2026
In vitro (cells) · 6 results
- NNT inhibits microglial activation via mitochondrial oxidative stress in spinal cord injury.
Li M · Neuroscience letters · 2026
In vitro (cells) · mouse · 4 results
- Evaluation of SS-31 as a Potential Therapeutic Target in the Treatment of Tendinopathy
Orthopaedic journal of sports medicine · 2020
In vitro (cells) · 4 results
- The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action.
Mitchell W · The Journal of biological chemistry · 2020
In vitro (cell-free) · 6 results
- Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation.
Wiersma M · Cells · 2019
Other design · 1 result
- Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats.
Zhang CX · Journal of nanobiotechnology · 2019
Not a test of Elamipretide (SS-31) alone · 13 results