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Study · Ex vivo tissue · bull · 2021

2 results

Antioxidant effect of Elamipretide on bull's sperm cells during freezing/thawing process.

Kowalczyk A, Czerniawska Piątkowska E

Andrology17 Mar 2021Cited by 15 (Europe PMC)

PMID33675580 (opens in a new tab)DOI10.1111/andr.12996 (opens in a new tab)PepBankPUB-33675580
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In bull semen frozen and thawed, Elamipretide at 5 and 10 µM was the most effective concentration for the tested sperm quality parameters.

    In plain wordsIn lab tests on bull sperm, elamipretide at 5 and 10 µM worked best to protect sperm quality after freezing.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseQuality of frozen-thawed sperm cells
    Study

    bulln = 36

    Cryopreserved bull sperm cells
    Comparator
    Control without Elamipretide
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    5 and 10 µM · added to semen extenderAs given in this study (bull).

    Source sentences

    Summary
    It has been shown that a concentration of 5 and 10 μM proved to be the most effective in terms of tested parameters of the quality of sperm cells subjected to cryopreservation.
    2 context sentences
    Summary · context
    The study included 36 healthy Simmental bulls with an average age of 2 ± 0.5 years housed individually in pens.
    Summary · context
    The first fraction was left for the control group (without Elamipretide), to the next were added in succession 0.1; 1; 5; and 10 μM of Elamipretide TFA (Trifluoroacetic) (MedChemExpress).
  2. 02LabEx vivo tissueEfficacy outcome

    In bull semen, adding Elamipretide to the cryopreservation extender significantly improved the quality and function of frozen-thawed sperm cells.

    In plain wordsIn lab tests on bull sperm, adding elamipretide before freezing improved the quality and function of the thawed sperm.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseQuality of frozen-thawed sperm cells
    Study

    bulln = 36

    Cryopreserved bull sperm cells
    Comparator
    Control without Elamipretide
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.1-10 µM · added to semen extenderAs given in this study (bull).

    Source sentences

    Summary
    In conclusion, addition of the Elamipretide to the cryopreservation extender significantly improved frozen-thawed sperm cells quality and their function.
    2 context sentences
    Summary · context
    The study included 36 healthy Simmental bulls with an average age of 2 ± 0.5 years housed individually in pens.
    Summary · context
    The first fraction was left for the control group (without Elamipretide), to the next were added in succession 0.1; 1; 5; and 10 μM of Elamipretide TFA (Trifluoroacetic) (MedChemExpress).

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

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