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Study · Ex vivo tissue · 2020

3 results

Mitochondrial protein interaction landscape of SS-31.

Chavez JD, Tang X, Campbell MD, Reyes G, Kramer PA, Stuppard R, Keller A, Zhang H, Rabinovitch PS, Marcinek DJ, Bruce JE

Proceedings of the National Academy of Sciences of the United States of America17 Jun 2020Cited by 163 (Europe PMC)

PMID32554501 (opens in a new tab)PMCIDPMC7334473 (opens in a new tab)DOI10.1073/pnas.2002250117 (opens in a new tab)PepBankPUB-32554501
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In mitochondria, cross-linking mass spectrometry showed that SS‑31-interacting proteins fall into two groups: oxidative phosphorylation proteins and 2-oxoglutarate metabolism proteins.

    In plain wordsIn lab tests, SS‑31 bound mitochondrial proteins that fall into two groups: ATP production proteins and 2-oxoglutarate metabolism proteins.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Not applicableSS-31 protein interactor groups in mitochondria
    Study

    n: not reported in source

    mitochondria
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The SS-31-interacting proteins, all known cardiolipin binders, fall into two groups, those involved in ATP production through the oxidative phosphorylation pathway and those involved in 2-oxoglutarate metabolic processes.
    1 context sentence
    Summary · context
    Here we utilize chemical cross-linking with mass spectrometry to identify protein interactors of SS-31 in mitochondria.
  2. 02LabEx vivo tissueMechanism

    In mitochondria, all protein interactors of SS‑31 identified by cross-linking were known cardiolipin binders.

    In plain wordsIn lab tests, all mitochondrial proteins that SS‑31 bound were already known to bind cardiolipin.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Not applicableCardiolipin binding of SS-31 interactors
    Study

    n: not reported in source

    mitochondria
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The SS-31-interacting proteins, all known cardiolipin binders
    1 context sentence
    Summary · context
    Here we utilize chemical cross-linking with mass spectrometry to identify protein interactors of SS-31 in mitochondria.
  3. 03LabEx vivo tissueMechanism

    In mitochondria, residues cross-linked with SS‑31 revealed binding regions that in many cases lie near cardiolipin-protein interacting regions.

    In plain wordsIn lab tests, SS‑31 binding regions on mitochondrial proteins were often close to the regions where cardiolipin binds.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Not applicableSS-31 cross-linked binding regions relative to cardiolipin sites
    Study

    n: not reported in source

    mitochondria
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Residues cross-linked with SS-31 reveal binding regions that in many cases, are proximal to cardiolipin-protein interacting regions.
    1 context sentence
    Summary · context
    Here we utilize chemical cross-linking with mass spectrometry to identify protein interactors of SS-31 in mitochondria.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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