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Study · Animal study (in vivo) · rat · 2026

4 results

Disruption of hippocampal mitochondrial function underlies opioid-induced postoperative cognitive dysfunction in aged rats.

Muscat SM, Deems NP, Alvarez BD, Butler MJ, Gonzalez Olmo BM, Kolonay DW, Sanders HF, Scaria EA, Mackey-Alfonso SE, Blackwell JA, DeMarsh JW, Bettes MN and 6 more

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Quach TT, Cortese GP, Glasper ER, Leuner B, Baskin KK, Barrientos RM

Brain, behavior, and immunity3 Aug 2026

PMID42546889 (opens in a new tab)DOI10.1016/j.bbi.2026.106942 (opens in a new tab)PepBankPUB-42546889
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aged rats with surgery and morphine, SS‑31 given four weeks after surgery rescued hippocampal-dependent memory.

    In plain wordsIn aged rats after surgery and morphine, SS‑31 given four weeks later restored memory that depends on the hippocampus.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseHippocampal-dependent memory
    Study

    ratn: not reported in source

    aged rat model of surgery with perioperative morphine
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    targeted mitochondrial rejuvenation with SS-31 four weeks post-surgery robustly rescued hippocampal-dependent memory
    1 context sentence
    Summary · context
    Here, using an aged rat model of surgery with perioperative morphine administration, we investigated how synaptic, axonal, and mitochondrial abnormalities contribute to persistent hippocampal memory deficits, and evaluated therapeutic strategies targeting neuroinflammation and mitochondrial dysfunction.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In aged rats with surgery and morphine, SS‑31 normalized hippocampal mitochondrial respiratory function.

    In plain wordsIn aged rats after surgery and morphine, SS‑31 brought mitochondrial breathing function in the hippocampus back to normal.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseHippocampal mitochondrial respiratory function
    Study

    ratn: not reported in source

    aged rat model of surgery with perioperative morphine
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    targeted mitochondrial rejuvenation with SS-31 four weeks post-surgery robustly rescued hippocampal-dependent memory and normalized mitochondrial respiratory function
    1 context sentence
    Summary · context
    Here, using an aged rat model of surgery with perioperative morphine administration, we investigated how synaptic, axonal, and mitochondrial abnormalities contribute to persistent hippocampal memory deficits, and evaluated therapeutic strategies targeting neuroinflammation and mitochondrial dysfunction.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In aged rats with surgery and morphine, DNA oxidation stayed elevated after SS‑31 treatment.

    In plain wordsIn aged rats after surgery and morphine, DNA oxidation in the brain stayed high despite SS‑31.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeHippocampal DNA oxidation
    Study

    ratn: not reported in source

    aged rat model of surgery with perioperative morphine
    Outcome group
    Aging markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    targeted mitochondrial rejuvenation with SS-31 four weeks post-surgery robustly rescued hippocampal-dependent memory and normalized mitochondrial respiratory function despite persistently elevated DNA oxidation
    1 context sentence
    Summary · context
    Here, using an aged rat model of surgery with perioperative morphine administration, we investigated how synaptic, axonal, and mitochondrial abnormalities contribute to persistent hippocampal memory deficits, and evaluated therapeutic strategies targeting neuroinflammation and mitochondrial dysfunction.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In aged rats with surgery and morphine, circulating Nf-L stayed elevated after SS‑31 treatment.

    In plain wordsIn aged rats after surgery and morphine, a blood marker of nerve fibre damage stayed high despite SS‑31.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeCirculating neurofilament light chain
    Study

    ratn: not reported in source

    aged rat model of surgery with perioperative morphine
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    targeted mitochondrial rejuvenation with SS-31 four weeks post-surgery robustly rescued hippocampal-dependent memory and normalized mitochondrial respiratory function despite persistently elevated DNA oxidation and Nf-L
    1 context sentence
    Summary · context
    Here, using an aged rat model of surgery with perioperative morphine administration, we investigated how synaptic, axonal, and mitochondrial abnormalities contribute to persistent hippocampal memory deficits, and evaluated therapeutic strategies targeting neuroinflammation and mitochondrial dysfunction.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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