Skip to content

Study · Ex vivo tissue · rat · 2025

8 results

Cadmium-cardiolipin disruption of respirasome assembly and redox balance through mitochondrial membrane rigidification.

Romanova N, Sule K, Issler T, Hebrok D, Persicke M, Thévenod F, Prenner EJ, Lee WK

Journal of lipid research27 Jan 2025Cited by 12 (Europe PMC)

PMID39880166 (opens in a new tab)PMCIDPMC11905837 (opens in a new tab)DOI10.1016/j.jlr.2025.100750 (opens in a new tab)PepBankPUB-39880166
Read at sourcePubMedAsk about this study
Jump to 8 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In rat kidney cortex mitochondria exposed to cadmium, MTP-131 attenuated Cd-induced H2O2 production.

    In plain wordsIn lab tests on rat kidney mitochondria, elamipretide lowered the hydrogen peroxide caused by cadmium.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCd-induced H2O2 in kidney cortex mitochondria
    Study

    ratn: not reported in source

    Rat kidney cortex mitochondria
    Comparator
    Cadmium alone
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    Dose not stated

    Measurements

    Attenuation of Cd-induced H2O2
    ≈ 30%
    rKC mitochondria

    Source sentences

    Summary
    MTP-131 attenuated Cd-induced H2O2 (∼30%)
  2. 02LabEx vivo tissueMechanism

    In rat kidney cortex mitochondria exposed to cadmium, MTP-131 attenuated Cd-induced cytochrome c release.

    In plain wordsIn lab tests on rat kidney mitochondria, elamipretide reduced cytochrome c release caused by cadmium.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCd-induced cytochrome c release
    Study

    ratn: not reported in source

    Rat kidney cortex mitochondria
    Comparator
    Cadmium alone
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated

    Measurements

    Attenuation of Cd-induced cytochrome c release
    ≈ 25%
    rKC mitochondria

    Source sentences

    Summary
    cytochrome c release (∼25%)
  3. 03LabEx vivo tissueMechanism

    In rat kidney cortex mitochondria exposed to cadmium, MTP-131 did not attenuate osmotic swelling.

    In plain wordsIn lab tests on rat kidney mitochondria, elamipretide did not reduce swelling caused by cadmium.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeCd-induced osmotic swelling
    Study

    ratn: not reported in source

    Rat kidney cortex mitochondria
    Comparator
    Cadmium alone
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MTP-131 attenuated Cd-induced H2O2 (∼30%) and cytochrome c release (∼25%), but not osmotic swelling, in rKC mitochondria
  4. 04LabIn vitro (cells)Mechanism

    In human proximal tubule cells exposed to cadmium, MTP-131 (elamipretide) reversed the loss of respiratory supercomplex formation.

    In plain wordsIn lab tests on kidney cells, elamipretide reversed the loss of mitochondrial protein complexes caused by cadmium.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseRespiratory supercomplex formation after cadmium exposure
    Study

    humann: not reported in source

    Human proximal convoluted tubule (HPCT) cells
    Comparator
    Cadmium alone
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    0.1 µMAs given in this study (human).

    Measurements

    Supercomplex formation loss with Cd
    ≈ 30%
    5 µM Cd, 6 h, HPCTs
    MTP-131 concentration
    0.1 µM
    HPCTs

    Source sentences

    Summary
    Blue native gel electrophoresis evidenced ∼30% loss of I+III2+IVn SC formation after 5 μM Cd for 6 h in HPCTs, which was reversed by CL-binding drug MTP-131/SS-31/elamipretide (0.1 μM), yet α-tocopherol-insensitive.
  5. 05LabIn vitro (cells)Mechanism

    In human proximal tubule cells exposed to cadmium, MTP-131 attenuated Cd-induced ROS.

    In plain wordsIn lab tests on human kidney cells, elamipretide lowered harmful oxygen molecules caused by cadmium.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCd-induced ROS in HPCT cells
    Study

    humann: not reported in source

    Human proximal convoluted tubule (HPCT) cells
    Comparator
    Cadmium alone
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    Dose not stated

    Measurements

    Attenuation of Cd-induced ROS
    ≈ 25%
    HPCTs

    Source sentences

    Summary
    as well as Cd-induced ROS (∼25%) in HPCTs.
  6. 06LabIn vitro (cell-free)Mechanism

    MTP-131 binding to inner mitochondrial membrane biomimetic nanoliposomes decreased zeta potential.

    In plain wordsIn lab tests with artificial membranes, elamipretide binding lowered the surface charge of the membrane vesicles.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseZeta potential of IMM biomimetic nanoliposomes
    Study

    n: not reported in source

    IMM biomimetic nanoliposomes
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MTP-131 binding to IMM biomimetic nanoliposomes decreased zeta potential
  7. 07LabIn vitro (cell-free)Mechanism

    MTP-131 binding to inner mitochondrial membrane biomimetic nanoliposomes prevented the Cd-induced increase in liposome size.

    In plain wordsIn lab tests with artificial membranes, elamipretide stopped cadmium from making the membrane vesicles larger.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCd-induced liposome size increase
    Study

    n: not reported in source

    IMM biomimetic nanoliposomes
    Comparator
    Cadmium alone
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MTP-131 binding to IMM biomimetic nanoliposomes decreased zeta potential, prevented Cd-induced liposome size increase
  8. 08LabIn vitro (cell-free)Mechanism

    MTP-131 binding to inner mitochondrial membrane biomimetic nanoliposomes prevented Cd-induced membrane rigidification.

    In plain wordsIn lab tests with artificial membranes, elamipretide stopped cadmium from stiffening the membrane.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCd-induced membrane rigidification
    Study

    n: not reported in source

    IMM biomimetic nanoliposomes
    Comparator
    Cadmium alone
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MTP-131 binding to IMM biomimetic nanoliposomes decreased zeta potential, prevented Cd-induced liposome size increase, and membrane rigidification reported by laurdan

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.