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Study · Ex vivo tissue · mouse · 2026

15 results

SS-31 improves the quality of maternally aged oocytes by ameliorating mitochondrial function and metabolism.

Xiong D, Zhang Y, Wei J, Wang L, Zhang G, Yu L, Zeng J, Liu W

Journal of ovarian research29 Jan 2026

PMID41612464 (opens in a new tab)PMCIDPMC12930897 (opens in a new tab)DOI10.1186/s13048-026-01975-5 (opens in a new tab)PepBankPUB-41612464
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    SS‑31 supplementation improved maturation of oocytes from aged mice.

    In plain wordsIn mouse egg cells from old mice, SS‑31 improved egg maturation.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseOocyte maturation
    Study

    mousen: not reported in source

    oocytes from aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, we found that SS-31 supplementation efficaciously improved oocyte maturation and early embryonic development from aged mice.
  2. 02LabEx vivo tissueEfficacy outcome

    SS‑31 supplementation improved early embryonic development from oocytes of aged mice.

    In plain wordsIn lab tests with eggs from old mice, SS‑31 improved early embryo development.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseEarly embryonic development
    Study

    mousen: not reported in source

    oocytes from aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, we found that SS-31 supplementation efficaciously improved oocyte maturation and early embryonic development from aged mice.
  3. 03LabEx vivo tissueEfficacy outcome

    SS‑31 restored the normal spindle and chromosome structure in aged mouse oocytes.

    In plain wordsIn lab tests with eggs from old mice, SS‑31 restored normal spindle and chromosome structure.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseSpindle/chromosome structure
    Study

    mousen: not reported in source

    oocytes from aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Specifically, SS-31 remarkably restored the normal spindle/chromosome structure, fertilization ability, mitochondrial distribution, ΔΨm and mitophagy in aged oocytes.
  4. 04LabEx vivo tissueEfficacy outcome

    SS‑31 restored fertilization ability of aged mouse oocytes.

    In plain wordsIn lab tests with eggs from old mice, SS‑31 restored the ability to be fertilized.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseFertilization ability
    Study

    mousen: not reported in source

    oocytes from aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Specifically, SS-31 remarkably restored the normal spindle/chromosome structure, fertilization ability, mitochondrial distribution, ΔΨm and mitophagy in aged oocytes.
  5. 05LabEx vivo tissueMechanism

    SS‑31 restored the normal mitochondrial distribution in aged mouse oocytes.

    In plain wordsIn lab tests with eggs from old mice, SS‑31 restored normal placement of mitochondria.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Not applicableMitochondrial distribution
    Study

    mousen: not reported in source

    oocytes from aged mice
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Specifically, SS-31 remarkably restored the normal spindle/chromosome structure, fertilization ability, mitochondrial distribution, ΔΨm and mitophagy in aged oocytes.
  6. 06LabEx vivo tissueMechanism

    SS‑31 restored mitochondrial membrane potential in aged mouse oocytes.

    In plain wordsIn lab tests with eggs from old mice, SS‑31 restored mitochondrial membrane potential.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial membrane potential (ΔΨm)
    Study

    mousen: not reported in source

    oocytes from aged mice
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Specifically, SS-31 remarkably restored the normal spindle/chromosome structure, fertilization ability, mitochondrial distribution, ΔΨm and mitophagy in aged oocytes.
  7. 07LabEx vivo tissueMechanism

    SS‑31 restored mitophagy in aged mouse oocytes.

    In plain wordsIn lab tests with eggs from old mice, SS‑31 restored the clearing of damaged mitochondria.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitophagy
    Study

    mousen: not reported in source

    oocytes from aged mice
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Specifically, SS-31 remarkably restored the normal spindle/chromosome structure, fertilization ability, mitochondrial distribution, ΔΨm and mitophagy in aged oocytes.
  8. 08LabEx vivo tissueEfficacy outcome

    SS‑31 reduced aneuploidy in aged mouse oocytes.

    In plain wordsIn lab tests with eggs from old mice, SS‑31 reduced eggs with the wrong chromosome number.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseOocyte aneuploidy
    Study

    mousen: not reported in source

    oocytes from aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, SS-31 reduced oocyte aneuploidy, ROS accumulation and DNA damage.
  9. 09LabEx vivo tissueMechanism

    SS‑31 reduced reactive oxygen species accumulation in aged mouse oocytes.

    In plain wordsIn lab tests with eggs from old mice, SS‑31 reduced harmful oxygen molecules.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseROS accumulation
    Study

    mousen: not reported in source

    oocytes from aged mice
    Outcome group
    Aging markers · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, SS-31 reduced oocyte aneuploidy, ROS accumulation and DNA damage.
  10. 10LabEx vivo tissueMechanism

    SS‑31 reduced DNA damage in aged mouse oocytes.

    In plain wordsIn lab tests with eggs from old mice, SS‑31 reduced DNA damage.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseDNA damage
    Study

    mousen: not reported in source

    oocytes from aged mice
    Outcome group
    Aging markers · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, SS-31 reduced oocyte aneuploidy, ROS accumulation and DNA damage.
  11. 11LabEx vivo tissueMechanism

    In aged mouse oocytes, single-cell transcriptome analysis showed that SS‑31 increased maternal mRNA degradation.

    In plain wordsIn lab tests with eggs from old mice, SS‑31 increased the breakdown of maternal messenger RNA.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMaternal mRNA degradation
    Study

    mousen: not reported in source

    oocytes from aged mice
    Outcome group
    Aging markers · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    single-cell transcriptome analysis reveals that SS-31 increased the maternal mRNA degradation
  12. 12LabEx vivo tissueMechanism

    In aged mouse oocytes, SS‑31 increased the levels of genes associated with mitochondrial function and mitophagy, such as Pink1, Rps27a, Tomm7 and Map1lc3b.

    In plain wordsIn lab tests with eggs from old mice, SS‑31 raised the levels of genes linked to mitochondrial function.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial function and mitophagy gene levels
    Study

    mousen: not reported in source

    oocytes from aged mice
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the levels of genes associated with mitochondrial function and mitophagy in aged oocytes, such as Pink1, Rps27a, Tomm7 and Map1lc3b.
  13. 13LabEx vivo tissueMechanism

    In aged mouse oocytes, SS‑31 suppressed chromatin organization, histone modification and chromatin remodeling pathways.

    In plain wordsIn lab tests with eggs from old mice, SS‑31 suppressed gene-packaging pathways.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseChromatin organization, histone modification and chromatin remodeling pathways
    Study

    mousen: not reported in source

    oocytes from aged mice
    Outcome group
    Aging markers · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, SS-31 suppressed chromatin organization, histone modification and chromatin remodeling pathways.
  14. 14LabEx vivo tissueMechanism

    In aged mouse oocytes, SS‑31 increased the level of spermidine.

    In plain wordsIn lab tests with eggs from old mice, SS‑31 raised spermidine, a molecule that protects eggs against aging.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseSpermidine level
    Study

    mousen: not reported in source

    oocytes from aged mice
    Outcome group
    Aging markers · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, we applied the single-cell untargeted metabolomics to identify that SS-31 increased the levels of spermidine and GSH, which were critical metabolites to protect oocytes against aging.
  15. 15LabEx vivo tissueMechanism

    In aged mouse oocytes, SS‑31 increased the level of glutathione.

    In plain wordsIn lab tests with eggs from old mice, SS‑31 raised glutathione, a molecule that protects eggs against aging.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseGlutathione (GSH) level
    Study

    mousen: not reported in source

    oocytes from aged mice
    Outcome group
    Aging markers · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, we applied the single-cell untargeted metabolomics to identify that SS-31 increased the levels of spermidine and GSH, which were critical metabolites to protect oocytes against aging.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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