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Study · Animal study (in vivo) · mouse · 2025

4 results

Environmental enrichment highlights mitochondrial inner membrane function as a therapeutic target for sepsis-associated encephalopathy.

Wang SX, Yin XY, Jian JX, Ji MH, Yang JJ, Shen JC

Brain research24 Jun 2025

PMID40571047 (opens in a new tab)DOI10.1016/j.brainres.2025.149790 (opens in a new tab)PepBankPUB-40571047
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In LPS-treated mice, SS‑31 administration maintained mitochondrial integrity.

    In plain wordsIn mice given LPS, SS‑31 helped keep mitochondria intact.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Direction not reportedMitochondrial integrity
    Study

    mousen: not reported in source

    LPS-induced sepsis-associated encephalopathy
    Comparator
    LPS without SS-31
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Importantly, the administration of SS-31 was found to maintain mitochondrial integrity
    1 context sentence
    Summary · context
    LPS exposure resulted in cognitive deficits, particularly characterized by diminished working memory.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In LPS-treated mice, SS‑31 administration enhanced the functionality of the mitochondrial inner membrane.

    In plain wordsIn mice given LPS, SS‑31 improved how well the mitochondrial inner membrane worked.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial inner membrane function
    Study

    mousen: not reported in source

    LPS-induced sepsis-associated encephalopathy
    Comparator
    LPS without SS-31
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    enhance the functionality of the mitochondrial inner membrane, and ultimately mitigate both synaptic and cognitive deficits.
    1 context sentence
    Summary · context
    LPS exposure resulted in cognitive deficits, particularly characterized by diminished working memory.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In LPS-treated mice, SS‑31 administration mitigated synaptic deficits.

    In plain wordsIn mice given LPS, SS‑31 reduced synaptic problems.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseSynaptic deficits
    Study

    mousen: not reported in source

    LPS-induced sepsis-associated encephalopathy
    Comparator
    LPS without SS-31
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Importantly, the administration of SS-31 was found to maintain mitochondrial integrity, enhance the functionality of the mitochondrial inner membrane, and ultimately mitigate both synaptic and cognitive deficits.
    1 context sentence
    Summary · context
    LPS exposure resulted in cognitive deficits, particularly characterized by diminished working memory.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In LPS-treated mice, SS‑31 administration mitigated cognitive deficits.

    In plain wordsIn mice given LPS, SS‑31 reduced memory and thinking problems.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCognitive deficits
    Study

    mousen: not reported in source

    LPS-induced sepsis-associated encephalopathy
    Comparator
    LPS without SS-31
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Importantly, the administration of SS-31 was found to maintain mitochondrial integrity, enhance the functionality of the mitochondrial inner membrane, and ultimately mitigate both synaptic and cognitive deficits.
    1 context sentence
    Summary · context
    LPS exposure resulted in cognitive deficits, particularly characterized by diminished working memory.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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