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Study · Animal study (in vivo) · mouse · 2025

2 results

The potential of mitochondrially-targeted tetrapeptide in protecting against noise-induced hearing impairment.

Kumar NA, Marouf A, Alagramam KN, Stepanyan R

Neuroreport2 Dec 2024Cited by 1 (Europe PMC)

PMID39661536 (opens in a new tab)DOI10.1097/wnr.0000000000002124 (opens in a new tab)PepBankPUB-39661536
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice exposed to octave-band noise, elamipretide prevented the noise-induced elevation of ABR thresholds.

    In plain wordsIn mice exposed to loud noise, elamipretide prevented the rise in hearing thresholds.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseABR threshold elevation after noise
    Study

    mousen: not reported in source

    noise-induced hearing loss (CBA/J mice)
    Comparator
    Noise-exposed controls
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Elamipretide treatment prevented the OBN-induced elevation of ABR thresholds
    2 context sentences
    Summary · context
    To test the hypothesis that elamipretide treatment mitigates NIHL, 16-week-old male and female CBA/J mice were exposed to 8-16 kHz octave-band noise (OBN) at 98 dB SPL for 2 hours.
    Summary · context
    Elamipretide was administered intraperitoneally immediately after noise exposure and continued for 2 weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice exposed to octave-band noise, elamipretide prevented the noise-induced attenuation of ABR wave-I amplitude.

    In plain wordsIn mice exposed to loud noise, elamipretide prevented the drop in hearing nerve signal size.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseABR wave-I amplitude attenuation after noise
    Study

    mousen: not reported in source

    noise-induced hearing loss (CBA/J mice)
    Comparator
    Noise-exposed controls
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    and the attenuation of wave-I amplitude.
    2 context sentences
    Summary · context
    To test the hypothesis that elamipretide treatment mitigates NIHL, 16-week-old male and female CBA/J mice were exposed to 8-16 kHz octave-band noise (OBN) at 98 dB SPL for 2 hours.
    Summary · context
    Elamipretide was administered intraperitoneally immediately after noise exposure and continued for 2 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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