Elamipretide as a potential candidate for relieving cryodamage to human spermatozoa during cryopreservation.

Bai H, Zhang Y, Tian S, Hu R, Liang Y, Gao J, Wang Y, Wu B

Cryobiology30 Mar 2020Cited by 13 (Europe PMC)

PMID32240641DOI10.1016/j.cryobiol.2020.03.011PepBankPUB-32240641

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
In human sperm after freeze-thaw, adding elamipretide (1 and 10 µM) to the freeze medium improved post-thaw motility.
In plain wordsIn lab tests on human sperm, elamipretide in the freezing medium improved sperm movement after thawing.
Peptide
Elamipretide (SS-31)
Outcome
IncreasePost-thaw sperm motility
Study
humann: not reported in source
Human spermatozoa cryopreservation (freeze-thaw)
Comparator
0.0 µM Elamipretide
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 and 10 µM · added to freeze mediumAs given in this study (human).
Source sentences
Summary
The results showed that supplementation of the freeze media with Elamipretide (1 and 10 μM) significantly improved post-thaw sperm parameters including motility and viability, stability of the plasma membrane, and mitochondria and chromosomes.
1 context sentence(design, population, supporting numbers)
Summary · context
Semen samples were collected and cryopreserved in freeze solution containing different concentrations (0.0, 0.1, 1, and 10 μM) of Elamipretide.
Report a problemFND-3224064101
02LabEx vivo tissueEfficacy outcome
In human sperm after freeze-thaw, adding elamipretide (1 and 10 µM) to the freeze medium improved post-thaw viability.
In plain wordsIn lab tests on human sperm, elamipretide in the freezing medium improved sperm survival after thawing.
Peptide
Elamipretide (SS-31)
Outcome
IncreasePost-thaw sperm viability
Study
humann: not reported in source
Human spermatozoa cryopreservation (freeze-thaw)
Comparator
0.0 µM Elamipretide
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 and 10 µM · added to freeze mediumAs given in this study (human).
Source sentences
Summary
The results showed that supplementation of the freeze media with Elamipretide (1 and 10 μM) significantly improved post-thaw sperm parameters including motility and viability, stability of the plasma membrane, and mitochondria and chromosomes.
1 context sentence(design, population, supporting numbers)
Summary · context
Semen samples were collected and cryopreserved in freeze solution containing different concentrations (0.0, 0.1, 1, and 10 μM) of Elamipretide.
Report a problemFND-3224064102
03LabEx vivo tissueEfficacy outcome
In human sperm after freeze-thaw, adding elamipretide (1 and 10 µM) improved the stability of the plasma membrane.
In plain wordsIn lab tests on human sperm, elamipretide in the freezing medium kept the cell membrane more stable after thawing.
Peptide
Elamipretide (SS-31)
Outcome
IncreasePlasma membrane stability
Study
humann: not reported in source
Human spermatozoa cryopreservation (freeze-thaw)
Comparator
0.0 µM Elamipretide
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 and 10 µM · added to freeze mediumAs given in this study (human).
Source sentences
Summary
The results showed that supplementation of the freeze media with Elamipretide (1 and 10 μM) significantly improved post-thaw sperm parameters including motility and viability, stability of the plasma membrane, and mitochondria and chromosomes.
1 context sentence(design, population, supporting numbers)
Summary · context
Semen samples were collected and cryopreserved in freeze solution containing different concentrations (0.0, 0.1, 1, and 10 μM) of Elamipretide.
Report a problemFND-3224064103
04LabEx vivo tissueEfficacy outcome
In human sperm after freeze-thaw, adding elamipretide (1 and 10 µM) improved the stability of mitochondria.
In plain wordsIn lab tests on human sperm, elamipretide in the freezing medium kept mitochondria more stable after thawing.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseMitochondrial stability
Study
humann: not reported in source
Human spermatozoa cryopreservation (freeze-thaw)
Comparator
0.0 µM Elamipretide
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 and 10 µM · added to freeze mediumAs given in this study (human).
Source sentences
Summary
The results showed that supplementation of the freeze media with Elamipretide (1 and 10 μM) significantly improved post-thaw sperm parameters including motility and viability, stability of the plasma membrane, and mitochondria and chromosomes.
1 context sentence(design, population, supporting numbers)
Summary · context
Semen samples were collected and cryopreserved in freeze solution containing different concentrations (0.0, 0.1, 1, and 10 μM) of Elamipretide.
Report a problemFND-3224064104
05LabEx vivo tissueEfficacy outcome
In human sperm after freeze-thaw, adding elamipretide (1 and 10 µM) improved the stability of chromosomes.
In plain wordsIn lab tests on human sperm, elamipretide in the freezing medium kept chromosomes more stable after thawing.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseChromosome stability
Study
humann: not reported in source
Human spermatozoa cryopreservation (freeze-thaw)
Comparator
0.0 µM Elamipretide
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
1 and 10 µM · added to freeze mediumAs given in this study (human).
Source sentences
Summary
The results showed that supplementation of the freeze media with Elamipretide (1 and 10 μM) significantly improved post-thaw sperm parameters including motility and viability, stability of the plasma membrane, and mitochondria and chromosomes.
1 context sentence(design, population, supporting numbers)
Summary · context
Semen samples were collected and cryopreserved in freeze solution containing different concentrations (0.0, 0.1, 1, and 10 μM) of Elamipretide.
Report a problemFND-3224064105
06LabEx vivo tissueEfficacy outcome
In human sperm after freeze-thaw, adding elamipretide significantly attenuated excessive oxidation.
In plain wordsIn lab tests on human sperm, elamipretide in the freezing medium reduced oxidative damage after thawing.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseExcessive oxidation after freeze-thaw
Study
humann: not reported in source
Human spermatozoa cryopreservation (freeze-thaw)
Comparator
0.0 µM Elamipretide
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · added to freeze mediumAs given in this study (human).
Source sentences
Summary
In addition, by adding Elamipretide, excessive oxidation and acrosome dysfunction in sperm cells undergoing freeze-thaw were also significantly attenuated.
1 context sentence(design, population, supporting numbers)
Summary · context
Semen samples were collected and cryopreserved in freeze solution containing different concentrations (0.0, 0.1, 1, and 10 μM) of Elamipretide.
Report a problemFND-3224064106
07LabEx vivo tissueEfficacy outcome
In human sperm after freeze-thaw, adding elamipretide significantly attenuated acrosome dysfunction.
In plain wordsIn lab tests on human sperm, elamipretide in the freezing medium reduced damage to the sperm acrosome after thawing.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseAcrosome dysfunction after freeze-thaw
Study
humann: not reported in source
Human spermatozoa cryopreservation (freeze-thaw)
Comparator
0.0 µM Elamipretide
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · added to freeze mediumAs given in this study (human).
Source sentences
Summary
In addition, by adding Elamipretide, excessive oxidation and acrosome dysfunction in sperm cells undergoing freeze-thaw were also significantly attenuated.
1 context sentence(design, population, supporting numbers)
Summary · context
Semen samples were collected and cryopreserved in freeze solution containing different concentrations (0.0, 0.1, 1, and 10 μM) of Elamipretide.
Report a problemFND-3224064107

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

Keywords

PepBank is a research reference. Talk to a doctor before you use any peptide.