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Study · Animal study (in vivo) · mouse · 2025

7 results

Low expression of Frataxin might contribute to diabetic peripheral neuropathy in a mouse model.

Xia S, Wu L, Chen J, Li K, Bian D

Biochemical and biophysical research communications20 Dec 2024

PMID39721363 (opens in a new tab)DOI10.1016/j.bbrc.2024.151228 (opens in a new tab)PepBankPUB-39721363
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In db/db mice with diabetic peripheral neuropathy, SS‑31 markedly improved behavioral indices.

    In plain wordsIn diabetic mice with nerve damage, SS‑31 improved behavior test results.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Direction not reportedBehavioral indices
    Study

    mousen: not reported in source

    db/db mouse model of diabetic peripheral neuropathy
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, we found that the mitochondria-targeted antioxidant SS-31 markedly improved the behavioral indices
    1 context sentence
    Summary · context
    Our previous study showed that expression of Frataxin, encoded by the Fxn gene, is downregulated in leptin receptor knockout (so-called db/db) mice, a commonly used DPN mouse model.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In db/db mice with diabetic peripheral neuropathy, SS‑31 significantly mitigated damage to the sciatic nerve.

    In plain wordsIn diabetic mice, SS‑31 reduced damage to the sciatic nerve.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseSciatic nerve damage
    Study

    mousen: not reported in source

    db/db mouse model of diabetic peripheral neuropathy
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    significantly mitigated the damage to the sciatic nerve.
    1 context sentence
    Summary · context
    Our previous study showed that expression of Frataxin, encoded by the Fxn gene, is downregulated in leptin receptor knockout (so-called db/db) mice, a commonly used DPN mouse model.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In db/db mice, SS‑31 treatment elevated Fxn (frataxin) expression in the sciatic nerve.

    In plain wordsIn diabetic mice, SS‑31 raised frataxin gene activity in the sciatic nerve.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseFxn expression in sciatic nerve
    Study

    mousen: not reported in source

    db/db mouse model of diabetic peripheral neuropathy
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 treatment effectively elevated Fxn expression
    1 context sentence
    Summary · context
    Our previous study showed that expression of Frataxin, encoded by the Fxn gene, is downregulated in leptin receptor knockout (so-called db/db) mice, a commonly used DPN mouse model.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In db/db mice, SS‑31 treatment meliorated mitochondrial function in the sciatic nerve.

    In plain wordsIn diabetic mice, SS‑31 improved mitochondrial function in the sciatic nerve.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial function in sciatic nerve
    Study

    mousen: not reported in source

    db/db mouse model of diabetic peripheral neuropathy
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    meliorated mitochondrial function, and inflammation in the sciatic nerve (SCN).
    1 context sentence
    Summary · context
    Our previous study showed that expression of Frataxin, encoded by the Fxn gene, is downregulated in leptin receptor knockout (so-called db/db) mice, a commonly used DPN mouse model.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In db/db mice, SS‑31 treatment reduced inflammation in the sciatic nerve.

    In plain wordsIn diabetic mice, SS‑31 lowered inflammation in the sciatic nerve.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseInflammation in sciatic nerve
    Study

    mousen: not reported in source

    db/db mouse model of diabetic peripheral neuropathy
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and inflammation in the sciatic nerve (SCN).
    1 context sentence
    Summary · context
    Our previous study showed that expression of Frataxin, encoded by the Fxn gene, is downregulated in leptin receptor knockout (so-called db/db) mice, a commonly used DPN mouse model.
  6. 06LabIn vitro (cells)Mechanism

    In RSC96 cells exposed to high glucose, SS‑31 mitigated the disruption of iron and redox homeostasis.

    In plain wordsIn lab tests on nerve-support cells, SS‑31 reduced the iron and oxidative imbalance caused by high glucose.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseHigh glucose-induced disruption of iron and redox homeostasis
    Study

    n: not reported in source

    RSC96 cells with high glucose
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also found that SS-31 effectively mitigated high glucose-induced disruption of iron and redox homeostasis in RSC96 cells, a typical cell model of DPN, thereby improving mitochondrial function.
  7. 07LabIn vitro (cells)Efficacy outcome

    In RSC96 cells exposed to high glucose, SS‑31 improved mitochondrial function.

    In plain wordsIn lab tests on nerve-support cells, SS‑31 improved mitochondrial function under high glucose.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial function in high-glucose cells
    Study

    n: not reported in source

    RSC96 cells with high glucose
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    thereby improving mitochondrial function.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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