Skip to content

Study · Ex vivo tissue · mouse · 2023

1 result

Mitochondrial connexin43 and mitochondrial KATP channels modulate triggered arrhythmias in mouse ventricular muscle.

Sato H, Nishiyama M, Morita N, Satoh W, Hasegawa T, Someya Y, Okumura T, Koyama S, Shindoh C, Miura M

Pflugers Archiv : European journal of physiology28 Jan 2023Cited by 5 (Europe PMC)

PMID36707457 (opens in a new tab)DOI10.1007/s00424-023-02789-w (opens in a new tab)PepBankPUB-36707457
Publisher pagePubMedAsk about this study
Jump to 1 result

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In cardiac-specific Cx43-deficient mice, SS‑31 increased the minimal extracellular Ca2+ concentration at which arrhythmias were induced.

    In plain wordsIn heart tissue from mice lacking Cx43, SS‑31 raised the calcium level needed to trigger arrhythmias.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMinimal extracellular Ca2+ concentration for arrhythmias
    Study

    mousen: not reported in source

    Trabeculae of cardiac-specific Cx43-deficient mice
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, in cCx43-/- mice, antioxidant peptide SS-31 and N-acetyl-L-cysteine increased the [Ca2+]o,min.
    1 context sentence
    Summary · context
    To assess arrhythmia susceptibility, the minimal extracellular Ca2+ concentration ([Ca2+]o,min), at which arrhythmias were induced by electrical stimulation, was determined in trabeculae.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.