Exenatide (exendin-4) studies: 530 papers with results
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- Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells.
Sherry NA · Endocrinology · 2007
Animal study (in vivo) · mouse · 16 results
- The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test.
Isacson R · European journal of pharmacology · 2011
Animal study (in vivo) · rodent · 8 results
- Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21.
Müller TD · Journal of peptide science : an official publication of the European Peptide Society · 2012
Animal study (in vivo) · mouse · 3 results
- The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice.
Sørensen G · Physiology & behavior · 2015
Animal study (in vivo) · mouse · 5 results
- Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice.
Lee J · PloS one · 2012
Animal study (in vivo) · mouse · 19 results
- Antiobesity action of peripheral exenatide (exendin-4) in rodents: effects on food intake, body weight, metabolic status and side-effect measures.
Mack CM · International journal of obesity (2005) · 2006
Animal study (in vivo) · mouse and rat · 12 results
- Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis.
Li Y · PloS one · 2012
Animal study (in vivo) · mouse · 9 results
- A pH-Triggered Self-Unpacking Capsule Containing Zwitterionic Hydrogel-Coated MOF Nanoparticles for Efficient Oral Exendin-4 Delivery.
Zhou Y · Advanced materials (Deerfield Beach, Fla.) · 2021
Animal study (in vivo) · rat · 8 results
- Exendin-4 increases bone mineral density in type 2 diabetic OLETF rats potentially through the down-regulation of SOST/sclerostin in osteocytes.
Kim JY · Life sciences · 2013
Animal study (in vivo) · rat · 5 results
- Exendin-4 exerts osteogenic actions in insulin-resistant and type 2 diabetic states.
Nuche-Berenguer B · Regulatory peptides · 2010
Animal study (in vivo) · rat · 11 results
- Exendin-4 decreases liver inflammation and atherosclerosis development simultaneously by reducing macrophage infiltration.
Wang Y · British journal of pharmacology · 2014
Animal study (in vivo) · mouse · 12 results
- Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease by exendin-4.
Chen S · Age (Dordrecht, Netherlands) · 2012
Animal study (in vivo) · rat · 7 results
- Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats.
Hayes MR · Obesity (Silver Spring, Md.) · 2011
Animal study (in vivo) · rat · 13 results
- Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice.
Himeno T · Diabetes · 2011
Animal study (in vivo) · mouse · 9 results
- Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat.
Pinney SE · Diabetologia · 2011
Animal study (in vivo) · rat · 9 results
- In vivo evaluation of an oral self-emulsifying drug delivery system (SEDDS) for exenatide.
Menzel C · Journal of controlled release : official journal of the Controlled Release Society · 2018
Animal study (in vivo) · rat · 6 results
- Rapidly dissolvable microneedle patches for transdermal delivery of exenatide.
Zhu Z · Pharmaceutical research · 2014
Animal study (in vivo) · 5 results
- Exendin-4 modulates diabetes onset in nonobese diabetic mice.
Hadjiyanni I · Endocrinology · 2008
Animal study (in vivo) · mouse · 11 results
- Exendin-4 decreases amphetamine-induced locomotor activity.
Erreger K · Physiology & behavior · 2012
Animal study (in vivo) · rat · 4 results
- Interactions of exendin-(9-39) with the effects of glucagon-like peptide-1-(7-36) amide and of exendin-4 on arterial blood pressure and heart rate in rats.
Barragán JM · Regulatory peptides · 1996
Animal study (in vivo) · rat · 7 results
- The glucagon-like peptide 1 receptor agonist Exendin-4 decreases relapse-like drinking in socially housed mice.
Thomsen M · Pharmacology, biochemistry, and behavior · 2017
Animal study (in vivo) · mouse · 8 results
- Insulin resistance and exendin-4 treatment for multiple system atrophy.
Bassil F · Brain : a journal of neurology · 2017
Animal study (in vivo) · mouse · 2 results
- Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats.
Xie Z · Neuropharmacology · 2018
Animal study (in vivo) · sprague-dawley rat · 10 results
- The glucose-lowering potential of exendin-4 orally delivered via a pH-sensitive nanoparticle vehicle and effects on subsequent insulin secretion in vivo.
Nguyen HN · Biomaterials · 2011
Animal study (in vivo) · rat · 6 results
- Exenatide reduces TNF-α expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats.
Solmaz V · European journal of pharmacology · 2015
Animal study (in vivo) · rat · 4 results
- Oral delivery of bioencapsulated exendin-4 expressed in chloroplasts lowers blood glucose level in mice and stimulates insulin secretion in beta-TC6 cells.
Kwon KC · Plant biotechnology journal · 2013
Animal study (in vivo) · mouse · 10 results
- GLP-1(7-36)-amide and Exendin-4 stimulate the HPA axis in rodents and humans.
Gil-Lozano M · Endocrinology · 2010
Animal study (in vivo) · 3 results
- Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin-interacting protein.
Chen J · Biochemical and biophysical research communications · 2006
Animal study (in vivo) · mouse · 11 results
- GLP-1 and exendin-4 can reverse hyperlipidic-related osteopenia.
Nuche-Berenguer B · The Journal of endocrinology · 2011
Animal study (in vivo) · rat · 10 results
- Exendin-4 in combination with adipose-derived stem cells promotes angiogenesis and improves diabetic wound healing.
Seo E · Journal of translational medicine · 2017
Animal study (in vivo) · mouse · 9 results
- The cardioprotective effect of melatonin and exendin-4 treatment in a rat model of cardiorenal syndrome.
Chua S · Journal of pineal research · 2016
Animal study (in vivo) · rat · 74 results
- Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet.
Gault VA · International journal of obesity (2005) · 2010
Animal study (in vivo) · mouse · 3 results
- Exendin-4 induced glucagon-like peptide-1 receptor activation reverses behavioral impairments of mild traumatic brain injury in mice.
Rachmany L · Age (Dordrecht, Netherlands) · 2013
Animal study (in vivo) · mouse · 5 results
- Exendin-4, a Glucagonlike Peptide-1 Receptor Agonist, Attenuates Breast Cancer Growth by Inhibiting NF-κB Activation.
Iwaya C · Endocrinology · 2017
Animal study (in vivo) · mouse · 9 results
- Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats.
Candeias E · Molecular neurobiology · 2018
Animal study (in vivo) · rat · 15 results
- Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces Alzheimer disease-associated tau hyperphosphorylation in the hippocampus of rats with type 2 diabetes.
Xu W · Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2015
Animal study (in vivo) · rat · 4 results
- Exendin-4 reduces ischemic brain injury in normal and aged type 2 diabetic mice and promotes microglial M2 polarization.
Darsalia V · PloS one · 2014
Animal study (in vivo) · mouse · 5 results
- Exendin-4 Protects against Hyperglycemia-Induced Cardiomyocyte Pyroptosis via the AMPK-TXNIP Pathway.
Wei H · Journal of diabetes research · 2019
Animal study (in vivo) · rat · 10 results
- Neuroprotective effect of the glucagon-like peptide-1 receptor agonist, synthetic exendin-4, in streptozotocin-induced diabetic rats.
Liu WJ · British journal of pharmacology · 2011
Animal study (in vivo) · rat · 7 results
- Exenatide does not evoke pancreatitis and attenuates chemically induced pancreatitis in normal and diabetic rodents.
Tatarkiewicz K · American journal of physiology. Endocrinology and metabolism · 2010
Animal study (in vivo) · mouse and rat · 17 results
- Exendin-4 Enhances Motor Function Recovery via Promotion of Autophagy and Inhibition of Neuronal Apoptosis After Spinal Cord Injury in Rats.
Li HT · Molecular neurobiology · 2016
Animal study (in vivo) · rat · 8 results
- Exendin-4 stimulation of cyclin A2 in beta-cell proliferation.
Song WJ · Diabetes · 2008
Animal study (in vivo) · mouse · 13 results
- Exendin-4 potently decreases ghrelin levels in fasting rats.
Pérez-Tilve D · Diabetes · 2007
Animal study (in vivo) · rat · 4 results
- Exendin 4 up-regulates expression of PDX 1 and hastens differentiation and maturation of human fetal pancreatic cells.
Movassat J · The Journal of clinical endocrinology and metabolism · 2002
Animal study (in vivo) · rat · 4 results
- Exenatide mitigated diet-induced vascular aging and atherosclerotic plaque growth in ApoE-deficient mice under chronic stress.
Yang G · Atherosclerosis · 2017
Animal study (in vivo) · mouse · 19 results
- SIRT1/HSF1/HSP pathway is essential for exenatide-alleviated, lipid-induced hepatic endoplasmic reticulum stress.
Zheng X · Hepatology (Baltimore, Md.) · 2017
Animal study (in vivo) · mouse · 14 results
- Exenatide alleviates mitochondrial dysfunction and cognitive impairment in the 5×FAD mouse model of Alzheimer's disease.
An J · Behavioural brain research · 2019
Animal study (in vivo) · mouse · 7 results
- Exendin-4 protects against post-myocardial infarction remodelling via specific actions on inflammation and the extracellular matrix.
Robinson E · Basic research in cardiology · 2015
Animal study (in vivo) · mouse · 14 results
- Brain activation following peripheral administration of the GLP-1 receptor agonist exendin-4.
Baraboi ED · American journal of physiology. Regulatory, integrative and comparative physiology · 2011
Animal study (in vivo) · 15 results
- Enhanced expression of PDX-1 and Ngn3 by exendin-4 during beta cell regeneration in STZ-treated mice.
Kodama S · Biochemical and biophysical research communications · 2005
Animal study (in vivo) · mouse · 7 results