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Study · Animal study (in vivo) · mouse · 2017

19 results

Exenatide mitigated diet-induced vascular aging and atherosclerotic plaque growth in ApoE-deficient mice under chronic stress.

Yang G, Lei Y, Inoue A, Piao L, Hu L, Jiang H, Sasaki T, Wu H, Xu W, Yu C, Zhao G, Ogasawara S, Okumura K, Kuzuya M, Cheng XW

Atherosclerosis13 Jul 2017Cited by 68 (Europe PMC)

PMID28734203 (opens in a new tab)DOI10.1016/j.atherosclerosis.2017.07.014 (opens in a new tab)PepBankPUB-28734203
Publisher pagePubMedAsk about this study
Jump to 19 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study19

19 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In stressed mice, exenatide decreased plaque microvessel density versus stress alone.

    In plain wordsIn stressed mice, exenatide decreased plaque microvessel density compared with stress alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreasePlaque microvessel density
    Study

    mousen: not reported in source

    Stressed high-fat diet-fed ApoE-deficient mice
    Comparator
    Stress alone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    As compared with the mice subjected to stress alone, the exenatide-treated mice had decreased plaque microvessel density, macrophage accumulation, broken elastin, and enhanced plaque collagen volume,
    1 context sentence
    Summary · context
    Mice fed the HF diet were divided into 2 groups and administered vehicle or exenatide for 12 weeks under stress conditions.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In stressed mice, exenatide decreased plaque macrophage accumulation versus stress alone.

    In plain wordsIn stressed mice, exenatide reduced plaque macrophage accumulation compared with stress alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseMacrophage accumulation
    Study

    mousen: not reported in source

    Stressed high-fat diet-fed ApoE-deficient mice
    Comparator
    Stress alone
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    As compared with the mice subjected to stress alone, the exenatide-treated mice had decreased plaque microvessel density, macrophage accumulation, broken elastin, and enhanced plaque collagen volume,
    1 context sentence
    Summary · context
    Mice fed the HF diet were divided into 2 groups and administered vehicle or exenatide for 12 weeks under stress conditions.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In stressed mice, exenatide decreased broken plaque elastin versus stress alone.

    In plain wordsIn stressed mice, exenatide reduced broken plaque elastin compared with stress alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseBroken elastin
    Study

    mousen: not reported in source

    Stressed high-fat diet-fed ApoE-deficient mice
    Comparator
    Stress alone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    As compared with the mice subjected to stress alone, the exenatide-treated mice had decreased plaque microvessel density, macrophage accumulation, broken elastin, and enhanced plaque collagen volume,
    1 context sentence
    Summary · context
    Mice fed the HF diet were divided into 2 groups and administered vehicle or exenatide for 12 weeks under stress conditions.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In stressed mice, exenatide increased plaque collagen volume versus stress alone.

    In plain wordsIn stressed mice, exenatide increased plaque collagen volume compared with stress alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreasePlaque collagen volume
    Study

    mousen: not reported in source

    Stressed high-fat diet-fed ApoE-deficient mice
    Comparator
    Stress alone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    As compared with the mice subjected to stress alone, the exenatide-treated mice had decreased plaque microvessel density, macrophage accumulation, broken elastin, and enhanced plaque collagen volume,
    1 context sentence
    Summary · context
    Mice fed the HF diet were divided into 2 groups and administered vehicle or exenatide for 12 weeks under stress conditions.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In stressed mice, exenatide lowered PPAR-α mRNA and/or protein levels versus stress alone.

    In plain wordsIn stressed mice, exenatide reduced PPAR-α levels compared with stress alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreasePPAR-α levels
    Study

    mousen: not reported in source

    Stressed high-fat diet-fed ApoE-deficient mice
    Comparator
    Stress alone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    and lowered levels of peroxisome proliferator-activated receptor-α, gp91phox osteopontin, C-X-C chemokine receptor-4, toll-like receptor-2 (TLR2), TLR4, and cathepsins K, L, and S mRNAs and/or proteins.
    1 context sentence
    Summary · context
    Mice fed the HF diet were divided into 2 groups and administered vehicle or exenatide for 12 weeks under stress conditions.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In stressed mice, exenatide lowered gp91phox mRNA and/or protein levels versus stress alone.

    In plain wordsIn stressed mice, exenatide reduced gp91phox levels compared with stress alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    Decreasegp91phox levels
    Study

    mousen: not reported in source

    Stressed high-fat diet-fed ApoE-deficient mice
    Comparator
    Stress alone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    and lowered levels of peroxisome proliferator-activated receptor-α, gp91phox osteopontin, C-X-C chemokine receptor-4, toll-like receptor-2 (TLR2), TLR4, and cathepsins K, L, and S mRNAs and/or proteins.
    1 context sentence
    Summary · context
    Mice fed the HF diet were divided into 2 groups and administered vehicle or exenatide for 12 weeks under stress conditions.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In stressed mice, exenatide lowered osteopontin mRNA and/or protein levels versus stress alone.

    In plain wordsIn stressed mice, exenatide reduced osteopontin levels compared with stress alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseOsteopontin levels
    Study

    mousen: not reported in source

    Stressed high-fat diet-fed ApoE-deficient mice
    Comparator
    Stress alone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    and lowered levels of peroxisome proliferator-activated receptor-α, gp91phox osteopontin, C-X-C chemokine receptor-4, toll-like receptor-2 (TLR2), TLR4, and cathepsins K, L, and S mRNAs and/or proteins.
    1 context sentence
    Summary · context
    Mice fed the HF diet were divided into 2 groups and administered vehicle or exenatide for 12 weeks under stress conditions.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In stressed mice, exenatide lowered C-X-C chemokine receptor-4 mRNA and/or protein levels versus stress alone.

    In plain wordsIn stressed mice, exenatide reduced CXCR4 levels compared with stress alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseCXCR4 levels
    Study

    mousen: not reported in source

    Stressed high-fat diet-fed ApoE-deficient mice
    Comparator
    Stress alone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    and lowered levels of peroxisome proliferator-activated receptor-α, gp91phox osteopontin, C-X-C chemokine receptor-4, toll-like receptor-2 (TLR2), TLR4, and cathepsins K, L, and S mRNAs and/or proteins.
    1 context sentence
    Summary · context
    Mice fed the HF diet were divided into 2 groups and administered vehicle or exenatide for 12 weeks under stress conditions.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In stressed mice, exenatide lowered TLR2 mRNA and/or protein levels versus stress alone.

    In plain wordsIn stressed mice, exenatide reduced TLR2 levels compared with stress alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseTLR2 levels
    Study

    mousen: not reported in source

    Stressed high-fat diet-fed ApoE-deficient mice
    Comparator
    Stress alone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    and lowered levels of peroxisome proliferator-activated receptor-α, gp91phox osteopontin, C-X-C chemokine receptor-4, toll-like receptor-2 (TLR2), TLR4, and cathepsins K, L, and S mRNAs and/or proteins.
    1 context sentence
    Summary · context
    Mice fed the HF diet were divided into 2 groups and administered vehicle or exenatide for 12 weeks under stress conditions.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In stressed mice, exenatide lowered TLR4 mRNA and/or protein levels versus stress alone.

    In plain wordsIn stressed mice, exenatide reduced TLR4 levels compared with stress alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseTLR4 levels
    Study

    mousen: not reported in source

    Stressed high-fat diet-fed ApoE-deficient mice
    Comparator
    Stress alone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    and lowered levels of peroxisome proliferator-activated receptor-α, gp91phox osteopontin, C-X-C chemokine receptor-4, toll-like receptor-2 (TLR2), TLR4, and cathepsins K, L, and S mRNAs and/or proteins.
    1 context sentence
    Summary · context
    Mice fed the HF diet were divided into 2 groups and administered vehicle or exenatide for 12 weeks under stress conditions.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In stressed mice, exenatide lowered cathepsin K mRNA and/or protein levels versus stress alone.

    In plain wordsIn stressed mice, exenatide reduced cathepsin K levels compared with stress alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseCathepsin K levels
    Study

    mousen: not reported in source

    Stressed high-fat diet-fed ApoE-deficient mice
    Comparator
    Stress alone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    and lowered levels of peroxisome proliferator-activated receptor-α, gp91phox osteopontin, C-X-C chemokine receptor-4, toll-like receptor-2 (TLR2), TLR4, and cathepsins K, L, and S mRNAs and/or proteins.
    1 context sentence
    Summary · context
    Mice fed the HF diet were divided into 2 groups and administered vehicle or exenatide for 12 weeks under stress conditions.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In stressed mice, exenatide lowered cathepsin L mRNA and/or protein levels versus stress alone.

    In plain wordsIn stressed mice, exenatide reduced cathepsin L levels compared with stress alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseCathepsin L levels
    Study

    mousen: not reported in source

    Stressed high-fat diet-fed ApoE-deficient mice
    Comparator
    Stress alone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    and lowered levels of peroxisome proliferator-activated receptor-α, gp91phox osteopontin, C-X-C chemokine receptor-4, toll-like receptor-2 (TLR2), TLR4, and cathepsins K, L, and S mRNAs and/or proteins.
    1 context sentence
    Summary · context
    Mice fed the HF diet were divided into 2 groups and administered vehicle or exenatide for 12 weeks under stress conditions.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In stressed mice, exenatide lowered cathepsin S mRNA and/or protein levels versus stress alone.

    In plain wordsIn stressed mice, exenatide reduced cathepsin S levels compared with stress alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseCathepsin S levels
    Study

    mousen: not reported in source

    Stressed high-fat diet-fed ApoE-deficient mice
    Comparator
    Stress alone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    and lowered levels of peroxisome proliferator-activated receptor-α, gp91phox osteopontin, C-X-C chemokine receptor-4, toll-like receptor-2 (TLR2), TLR4, and cathepsins K, L, and S mRNAs and/or proteins.
    1 context sentence
    Summary · context
    Mice fed the HF diet were divided into 2 groups and administered vehicle or exenatide for 12 weeks under stress conditions.
  14. 14AnimalAnimal study (in vivo)Mechanism

    In stressed mice, exenatide reduced aortic MMP-9 gene expression versus stress alone.

    In plain wordsIn stressed mice, exenatide reduced aortic MMP-9 gene expression compared with stress alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseMMP-9 gene expression
    Study

    mousen: not reported in source

    Stressed high-fat diet-fed ApoE-deficient mice
    Comparator
    Stress alone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Exenatide reduced aortic matrix metalloproteinase-9 (MMP-9) and MMP-2 gene expression and activities.
    1 context sentence
    Summary · context
    Mice fed the HF diet were divided into 2 groups and administered vehicle or exenatide for 12 weeks under stress conditions.
  15. 15AnimalAnimal study (in vivo)Mechanism

    In stressed mice, exenatide reduced aortic MMP-9 activity versus stress alone.

    In plain wordsIn stressed mice, exenatide reduced aortic MMP-9 activity compared with stress alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseMMP-9 activity
    Study

    mousen: not reported in source

    Stressed high-fat diet-fed ApoE-deficient mice
    Comparator
    Stress alone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Exenatide reduced aortic matrix metalloproteinase-9 (MMP-9) and MMP-2 gene expression and activities.
    1 context sentence
    Summary · context
    Mice fed the HF diet were divided into 2 groups and administered vehicle or exenatide for 12 weeks under stress conditions.
  16. 16AnimalAnimal study (in vivo)Mechanism

    In stressed mice, exenatide reduced aortic MMP-2 gene expression versus stress alone.

    In plain wordsIn stressed mice, exenatide reduced aortic MMP-2 gene expression compared with stress alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseMMP-2 gene expression
    Study

    mousen: not reported in source

    Stressed high-fat diet-fed ApoE-deficient mice
    Comparator
    Stress alone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Exenatide reduced aortic matrix metalloproteinase-9 (MMP-9) and MMP-2 gene expression and activities.
    1 context sentence
    Summary · context
    Mice fed the HF diet were divided into 2 groups and administered vehicle or exenatide for 12 weeks under stress conditions.
  17. 17AnimalAnimal study (in vivo)Mechanism

    In stressed mice, exenatide reduced aortic MMP-2 activity versus stress alone.

    In plain wordsIn stressed mice, exenatide reduced aortic MMP-2 activity compared with stress alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseMMP-2 activity
    Study

    mousen: not reported in source

    Stressed high-fat diet-fed ApoE-deficient mice
    Comparator
    Stress alone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Exenatide reduced aortic matrix metalloproteinase-9 (MMP-9) and MMP-2 gene expression and activities.
    1 context sentence
    Summary · context
    Mice fed the HF diet were divided into 2 groups and administered vehicle or exenatide for 12 weeks under stress conditions.
  18. 18AnimalAnimal study (in vivo)Mechanism

    In stressed mice, exenatide stimulated preadipocyte adiponectin expression versus stress alone.

    In plain wordsIn stressed mice, exenatide increased preadipocyte adiponectin expression compared with stress alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreasePreadipocyte adiponectin expression
    Study

    mousen: not reported in source

    Stressed high-fat diet-fed ApoE-deficient mice
    Comparator
    Stress alone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Exenatide also stimulated APN expression of preadipocytes and inhibited ox-low density lipoprotein-induced foam cell formation of monocytes in stressed mice.
    1 context sentence
    Summary · context
    Mice fed the HF diet were divided into 2 groups and administered vehicle or exenatide for 12 weeks under stress conditions.
  19. 19AnimalAnimal study (in vivo)Mechanism

    In stressed mice, exenatide inhibited oxidized LDL-induced monocyte foam cell formation versus stress alone.

    In plain wordsIn stressed mice, exenatide reduced monocyte foam cell formation caused by oxidized LDL compared with stress alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseMonocyte foam cell formation
    Study

    mousen: not reported in source

    Stressed high-fat diet-fed ApoE-deficient mice
    Comparator
    Stress alone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 12 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Exenatide also stimulated APN expression of preadipocytes and inhibited ox-low density lipoprotein-induced foam cell formation of monocytes in stressed mice.
    1 context sentence
    Summary · context
    Mice fed the HF diet were divided into 2 groups and administered vehicle or exenatide for 12 weeks under stress conditions.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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