Study · Animal study (in vivo) · mouse · 2012
19 resultsLee J, Hong SW, Chae SW, Kim DH, Choi JH, Bae JC, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Kim SW, Lee WY
PloS one17 Feb 2012Cited by 123 (Europe PMC)
19 results from studies that gave the peptide. No result from this study comes from people.
In obese mice, exendin‑4 decreased body weight.
In plain wordsIn mice with diet-induced obesity, exendin‑4 decreased body weight.
micen: not reported in source
High-fat diet-induced obese C57BL/6J miceSource sentences
Exendin-4 treatment decreased body weight, serum free fatty acid (FA), and triglyceride levels in HF-induced obese C57BL/6J mice.
In obese mice, exendin‑4 decreased serum free fatty acid levels.
In plain wordsIn mice with diet-induced obesity, exendin‑4 decreased blood free fatty acids.
micen: not reported in source
High-fat diet-induced obese C57BL/6J miceSource sentences
Exendin-4 treatment decreased body weight, serum free fatty acid (FA), and triglyceride levels in HF-induced obese C57BL/6J mice.
In obese mice, exendin‑4 decreased serum triglycerides.
In plain wordsIn mice with diet-induced obesity, exendin‑4 decreased blood triglycerides.
micen: not reported in source
High-fat diet-induced obese C57BL/6J miceSource sentences
Exendin-4 treatment decreased body weight, serum free fatty acid (FA), and triglyceride levels in HF-induced obese C57BL/6J mice.
In mice, exendin‑4 reversed high-fat diet-induced hepatic lipid accumulation.
In plain wordsIn mice, exendin‑4 reversed liver fat accumulation caused by a high-fat diet.
micen: not reported in source
High-fat diet-induced obese C57BL/6J miceSource sentences
Histological analysis showed that exendin-4 reversed HF-induced hepatic accumulation of lipids and inflammation.
In mice, exendin‑4 reversed high-fat diet-induced hepatic inflammation.
In plain wordsIn mice, exendin‑4 reversed liver inflammation caused by a high-fat diet.
micen: not reported in source
High-fat diet-induced obese C57BL/6J miceSource sentences
Histological analysis showed that exendin-4 reversed HF-induced hepatic accumulation of lipids and inflammation.
In mice, exendin‑4 increased Sirt1 mRNA expression.
In plain wordsIn mice, exendin‑4 increased Sirt1 gene expression.
micen: not reported in source
High-fat diet-induced obese C57BL/6J miceSource sentences
Exendin-4 treatment increased mRNA and protein expression of Sirt1 and its downstream factor, AMPK, in vivo and also induced genes associated with FA oxidation and glucose metabolism.
In mice, exendin‑4 increased Sirt1 protein expression.
In plain wordsIn mice, exendin‑4 increased Sirt1 protein levels.
micen: not reported in source
High-fat diet-induced obese C57BL/6J miceSource sentences
Exendin-4 treatment increased mRNA and protein expression of Sirt1 and its downstream factor, AMPK, in vivo and also induced genes associated with FA oxidation and glucose metabolism.
In mice, exendin‑4 increased AMPK mRNA expression.
In plain wordsIn mice, exendin‑4 increased AMPK gene expression.
micen: not reported in source
High-fat diet-induced obese C57BL/6J miceSource sentences
Exendin-4 treatment increased mRNA and protein expression of Sirt1 and its downstream factor, AMPK, in vivo and also induced genes associated with FA oxidation and glucose metabolism.
In mice, exendin‑4 increased AMPK protein expression.
In plain wordsIn mice, exendin‑4 increased AMPK protein levels.
micen: not reported in source
High-fat diet-induced obese C57BL/6J miceSource sentences
Exendin-4 treatment increased mRNA and protein expression of Sirt1 and its downstream factor, AMPK, in vivo and also induced genes associated with FA oxidation and glucose metabolism.
In mice, exendin‑4 induced genes associated with fatty acid oxidation.
In plain wordsIn mice, exendin‑4 increased expression of genes related to fatty acid use.
micen: not reported in source
High-fat diet-induced obese C57BL/6J miceSource sentences
Exendin-4 treatment increased mRNA and protein expression of Sirt1 and its downstream factor, AMPK, in vivo and also induced genes associated with FA oxidation and glucose metabolism.
In mice, exendin‑4 induced genes associated with glucose metabolism.
In plain wordsIn mice, exendin‑4 increased expression of genes related to glucose processing.
micen: not reported in source
High-fat diet-induced obese C57BL/6J miceSource sentences
Exendin-4 treatment increased mRNA and protein expression of Sirt1 and its downstream factor, AMPK, in vivo and also induced genes associated with FA oxidation and glucose metabolism.
In mice, exendin‑4 increased hepatic Lkb1 mRNA expression.
In plain wordsIn mice, exendin‑4 increased liver Lkb1 gene expression.
micen: not reported in source
High-fat diet-induced obese C57BL/6J miceSource sentences
In addition, a significant increase in the hepatic expression of Lkb1 and Nampt mRNA was observed in exendin-4-treated groups.
In mice, exendin‑4 increased hepatic Nampt mRNA expression.
In plain wordsIn mice, exendin‑4 increased liver Nampt gene expression.
micen: not reported in source
High-fat diet-induced obese C57BL/6J miceSource sentences
In addition, a significant increase in the hepatic expression of Lkb1 and Nampt mRNA was observed in exendin-4-treated groups.
In the exendin‑4 mouse study, phospho-Foxo1 expression increased.
In plain wordsIn mice, phospho-Foxo1 expression increased during exendin‑4 treatment.
micen: not reported in source
High-fat diet-induced obese C57BL/6J miceSource sentences
We also observed increased expression of phospho-Foxo1 and GLUT2, which are involved in hepatic glucose metabolism.
Therefore, we investigated whether the beneficial effects of exendin-4 treatment on fatty liver are mediated via Sirt1 in high-fat (HF) diet-induced obese C57BL/6J mice and related cell culture models.
In the exendin‑4 mouse study, GLUT2 expression increased.
In plain wordsIn mice, GLUT2 expression increased during exendin‑4 treatment.
micen: not reported in source
High-fat diet-induced obese C57BL/6J miceSource sentences
We also observed increased expression of phospho-Foxo1 and GLUT2, which are involved in hepatic glucose metabolism.
Therefore, we investigated whether the beneficial effects of exendin-4 treatment on fatty liver are mediated via Sirt1 in high-fat (HF) diet-induced obese C57BL/6J mice and related cell culture models.
In HepG2 and Huh7 cells, exendin‑4 increased GLP-1R mRNA expression dose-dependently.
In plain wordsIn cells, exendin‑4 increased GLP-1R gene expression as the dose increased.
n: not reported in source
HepG2 and Huh7 cellsSource sentences
In HepG2 and Huh7 cells, mRNA and protein expressions of GLP-1R were increased by exendin-4 treatment in a dose-dependent manner.
In HepG2 and Huh7 cells, exendin‑4 increased GLP-1R protein expression dose-dependently.
In plain wordsIn cells, exendin‑4 increased GLP-1R protein levels as the dose increased.
n: not reported in source
HepG2 and Huh7 cellsSource sentences
In HepG2 and Huh7 cells, mRNA and protein expressions of GLP-1R were increased by exendin-4 treatment in a dose-dependent manner.
In palmitic acid-treated HepG2 cells, exendin‑4 increased Sirt1 protein expression.
In plain wordsIn cells exposed to palmitic acid, exendin‑4 increased Sirt1 protein levels.
n: not reported in source
HepG2 cells treated with 0.4 mM palmitic acidSource sentences
Exendin-4 enhanced protein expression of Sirt1 and phospho-AMPKα in HepG2 cells treated with 0.4 mM palmitic acid.
In palmitic acid-treated HepG2 cells, exendin‑4 increased phospho-AMPKα protein expression.
In plain wordsIn cells exposed to palmitic acid, exendin‑4 increased phospho-AMPKα protein levels.
n: not reported in source
HepG2 cells treated with 0.4 mM palmitic acidSource sentences
Exendin-4 enhanced protein expression of Sirt1 and phospho-AMPKα in HepG2 cells treated with 0.4 mM palmitic acid.
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22 Oct 2026, 02:26 UTC
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21 Oct 2026, 18:59 UTC
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