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Study · Animal study (in vivo) · mouse · 2013

5 results

Exendin-4 induced glucagon-like peptide-1 receptor activation reverses behavioral impairments of mild traumatic brain injury in mice.

Rachmany L, Tweedie D, Li Y, Rubovitch V, Holloway HW, Miller J, Hoffer BJ, Greig NH, Pick CG

Age (Dordrecht, Netherlands)15 Aug 2012Cited by 77 (Europe PMC)

PMID22892942 (opens in a new tab)PMCIDPMC3776106 (opens in a new tab)DOI10.1007/s11357-012-9464-0 (opens in a new tab)PepBankPUB-22892942
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In mice with mild traumatic brain injury, Ex-4 was well tolerated.

    In plain wordsIn mice with mild brain injury, Ex-4 was well tolerated.

    Peptide
    Exenatide (exendin-4)
    Outcome
    Not applicableTolerability
    Study

    mousen: not reported in source

    Mild traumatic brain injury
    Comparator
    Saline
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    3.5 pM/kg/min · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    Ex-4 proved well-tolerated
    1 context sentence
    Summary · context
    To evaluate in vivo translation, we administered steady-state Ex-4 (3.5 pM/kg/min) or saline to control and mTBI mice over 7 days starting 48 h prior to or 1 h post-sham or mTBI (30 g weight drop under anesthesia).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, Ex-4 fully ameliorated injury-induced deficits in novel object recognition at 7 and 30 days.

    In plain wordsIn mice, Ex-4 corrected recognition deficits after brain injury compared with saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseNovel object recognition
    Study

    mousen: not reported in source

    Mild traumatic brain injury
    Comparator
    Saline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    3.5 pM/kg/min · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    Ex-4 proved well-tolerated and fully ameliorated mTBI-induced deficits in novel object recognition 7 and 30 days post-trauma.
    1 context sentence
    Summary · context
    To evaluate in vivo translation, we administered steady-state Ex-4 (3.5 pM/kg/min) or saline to control and mTBI mice over 7 days starting 48 h prior to or 1 h post-sham or mTBI (30 g weight drop under anesthesia).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, Ex-4 ameliorated apparent injury-induced impairment in the additional behavioral paradigms.

    In plain wordsIn mice, Ex-4 reduced apparent brain injury impairment in additional behavioral tests compared with saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseBehavioral impairment across additional paradigms
    Study

    mousen: not reported in source

    Mild traumatic brain injury
    Comparator
    Saline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    3.5 pM/kg/min · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    Less mTBI-induced impairment was evident in Y-maze, elevated plus maze, and passive avoidance paradigms, but when impairment was apparent Ex-4 induced amelioration.
    1 context sentence
    Summary · context
    To evaluate in vivo translation, we administered steady-state Ex-4 (3.5 pM/kg/min) or saline to control and mTBI mice over 7 days starting 48 h prior to or 1 h post-sham or mTBI (30 g weight drop under anesthesia).
  4. 04LabIn vitro (cells)Efficacy outcome

    In neuronal cultures, Ex-4 ameliorated hydrogen peroxide-induced oxidative stress.

    In plain wordsIn cells, Ex-4 reduced oxidative stress induced by hydrogen peroxide.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseOxidative stress
    Study

    n: not reported in source

    Neuronal cultures
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In neuronal cultures in this study, Ex-4 ameliorated H2O2-induced oxidative stress and glutamate toxicity.
  5. 05LabIn vitro (cells)Efficacy outcome

    In neuronal cultures, Ex-4 ameliorated glutamate toxicity.

    In plain wordsIn cells, Ex-4 reduced glutamate toxicity.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseGlutamate toxicity
    Study

    n: not reported in source

    Neuronal cultures
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In neuronal cultures in this study, Ex-4 ameliorated H2O2-induced oxidative stress and glutamate toxicity.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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