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Study · Animal study (in vivo) · rat · 2015

4 results

Exenatide reduces TNF-α expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats.

Solmaz V, Çınar BP, Yiğittürk G, Çavuşoğlu T, Taşkıran D, Erbaş O

European journal of pharmacology16 Sept 2015Cited by 81 (Europe PMC)

PMID26386291 (opens in a new tab)DOI10.1016/j.ejphar.2015.09.024 (opens in a new tab)PepBankPUB-26386291
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In STZ-treated rats, exenatide suppressed the increase in brain TNF-alpha compared with saline treatment.

    In plain wordsIn rats treated with STZ, exenatide reduced the rise in brain inflammation marker TNF-alpha compared with saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseBrain TNF-alpha
    Study

    ratn: not reported in source

    Intracerebroventricular streptozotocin Alzheimer disease model
    Comparator
    Saline-treated STZ rats
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    20 µgr/kg/day · intraperitoneal · two weeksAs given in this study (rat).

    Source sentences

    Summary
    While the brain TNF-α levels were significantly high in the saline-treated STZ group, exenatide treatment suppressed the increase in TNF-α levels.
    1 context sentence
    Summary · context
    Following stereotaxic surgery, STZ received rats were randomly distributed into two groups, and treated with either saline or exenatide 20 µgr/kg/day through intraperitoneally for two weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In STZ-treated rats, exenatide preserved brain ChAT activity compared with saline treatment.

    In plain wordsIn rats treated with STZ, exenatide preserved brain ChAT enzyme activity compared with saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseBrain choline acetyltransferase activity
    Study

    ratn: not reported in source

    Intracerebroventricular streptozotocin Alzheimer disease model
    Comparator
    Saline-treated STZ rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    20 µgr/kg/day · intraperitoneal · two weeksAs given in this study (rat).

    Source sentences

    Summary
    However, exenatide significantly preserved brain ChAT activity.
    2 context sentences
    Summary · context
    Saline-treated STZ group showed reduced ChAT activity compared to sham group.
    Summary · context
    Following stereotaxic surgery, STZ received rats were randomly distributed into two groups, and treated with either saline or exenatide 20 µgr/kg/day through intraperitoneally for two weeks.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In STZ-treated rats, exenatide improved memory compared with saline treatment.

    In plain wordsIn rats treated with STZ, exenatide improved memory compared with saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseMemory
    Study

    ratn: not reported in source

    Intracerebroventricular streptozotocin Alzheimer disease model
    Comparator
    Saline-treated STZ rats
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    20 µgr/kg/day · intraperitoneal · two weeksAs given in this study (rat).

    Source sentences

    Summary
    The cognitive performance was also impaired in saline group while exenatide improved memory in rats.
    1 context sentence
    Summary · context
    Following stereotaxic surgery, STZ received rats were randomly distributed into two groups, and treated with either saline or exenatide 20 µgr/kg/day through intraperitoneally for two weeks.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In STZ-treated rats, exenatide prevented hippocampal neuron loss compared with saline treatment.

    In plain wordsIn rats treated with STZ, exenatide prevented loss of hippocampal neurons compared with saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseHippocampal neuron count
    Study

    ratn: not reported in source

    Intracerebroventricular streptozotocin Alzheimer disease model
    Comparator
    Saline-treated STZ rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    20 µgr/kg/day · intraperitoneal · two weeksAs given in this study (rat).

    Source sentences

    Summary
    Moreover, exenatide treatment significantly prevented the decrease in hippocampal neurons.
    1 context sentence
    Summary · context
    Following stereotaxic surgery, STZ received rats were randomly distributed into two groups, and treated with either saline or exenatide 20 µgr/kg/day through intraperitoneally for two weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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