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Study · Animal study (in vivo) · rat · 1996

7 results

Interactions of exendin-(9-39) with the effects of glucagon-like peptide-1-(7-36) amide and of exendin-4 on arterial blood pressure and heart rate in rats.

Barragán JM, Rodríguez RE, Eng J, Blázquez E

Regulatory peptides1 Nov 1996Cited by 89 (Europe PMC)

PMID8952007 (opens in a new tab)DOI10.1016/s0167-0115(96)00113-9 (opens in a new tab)PepBankPUB-08952007
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In rats, exendin‑4 dose-dependently increased systolic arterial blood pressure.

    In plain wordsIn rats, exendin‑4 increased systolic blood pressure in a dose-dependent manner.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseSystolic arterial blood pressure
    Study

    ratn: not reported in source

    rats
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both GLP-1 (7-36) amide and exendin-4 produced a dose-dependent increase in systolic, diastolic and mean arterial blood pressure, as well as in heart rate, although the effect of exendin-4 was more prolonged.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In rats, exendin‑4 dose-dependently increased diastolic arterial blood pressure.

    In plain wordsIn rats, exendin‑4 increased diastolic blood pressure in a dose-dependent manner.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseDiastolic arterial blood pressure
    Study

    ratn: not reported in source

    rats
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both GLP-1 (7-36) amide and exendin-4 produced a dose-dependent increase in systolic, diastolic and mean arterial blood pressure, as well as in heart rate, although the effect of exendin-4 was more prolonged.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In rats, exendin‑4 dose-dependently increased mean arterial blood pressure.

    In plain wordsIn rats, exendin‑4 increased mean arterial blood pressure in a dose-dependent manner.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseMean arterial blood pressure
    Study

    ratn: not reported in source

    rats
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both GLP-1 (7-36) amide and exendin-4 produced a dose-dependent increase in systolic, diastolic and mean arterial blood pressure, as well as in heart rate, although the effect of exendin-4 was more prolonged.
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In rats, exendin‑4 dose-dependently increased heart rate.

    In plain wordsIn rats, exendin‑4 increased heart rate in a dose-dependent manner.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseHeart rate
    Study

    ratn: not reported in source

    rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both GLP-1 (7-36) amide and exendin-4 produced a dose-dependent increase in systolic, diastolic and mean arterial blood pressure, as well as in heart rate, although the effect of exendin-4 was more prolonged.
  5. 05AnimalAnimal study (in vivo)Activity measurement

    In rats, exendin‑4 cardiovascular effects lasted longer than those of GLP-1 (7-36) amide.

    In plain wordsIn rats, exendin‑4 cardiovascular effects lasted longer than those of GLP-1 (7-36) amide.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseDuration of cardiovascular effects
    Study

    ratn: not reported in source

    rats
    Comparator
    GLP-1 (7-36) amide
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both GLP-1 (7-36) amide and exendin-4 produced a dose-dependent increase in systolic, diastolic and mean arterial blood pressure, as well as in heart rate, although the effect of exendin-4 was more prolonged.

Studies that did not test the peptide alone2

In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Exenatide (exendin-4).

  1. 06AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Mechanism

    In rats, exendin-(9-39) pretreatment blocked the arterial blood pressure effect of exendin‑4.

    In plain wordsIn rats, exendin-(9-39) pretreatment blocked the blood pressure effect of exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseAntagonist blockade of blood pressure effect
    Study

    ratn: not reported in source

    rats
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    Under these experimental conditions the effect of the latter two peptides on arterial blood pressure and heart rate was blocked.
    1 context sentence
    Summary · context
    The antagonist effect of exendin-(9-39) on these cardiovascular parameters was also tested with 3000 ng of exendin-(9-39) intravenously administered 5 min before i.v. injection of 10 ng of either GLP-1 (7-36) amide or exendin-4.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

  2. 07AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Mechanism

    In rats, exendin-(9-39) pretreatment blocked the heart rate effect of exendin‑4.

    In plain wordsIn rats, exendin-(9-39) pretreatment blocked the heart rate effect of exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseAntagonist blockade of heart rate effect
    Study

    ratn: not reported in source

    rats
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    Under these experimental conditions the effect of the latter two peptides on arterial blood pressure and heart rate was blocked.
    1 context sentence
    Summary · context
    The antagonist effect of exendin-(9-39) on these cardiovascular parameters was also tested with 3000 ng of exendin-(9-39) intravenously administered 5 min before i.v. injection of 10 ng of either GLP-1 (7-36) amide or exendin-4.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · source ClinicalTrials.gov (opens in a new tab)

Status unknownPhase 1/2NCT02308254

Drug Trial of Lixisenatide on Gastric Emptying and Blood Pressure Drops in Type 2 Diabetics and Healthy People

Royal Adelaide Hospitaln = 30Nov 2013 to est. Apr 2016

Diabetes Mellitus · Gastroparesis

Trial pageClinicalTrials.govUpdated 29 Oct 2015

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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