The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test.

Isacson R, Nielsen E, Dannaeus K, Bertilsson G, Patrone C, Zachrisson O, Wikström L

European journal of pharmacology14 Oct 2010Cited by 131 (Europe PMC)

PMID20951130DOI10.1016/j.ejphar.2010.10.008PepBankPUB-20951130

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In adult rodents, chronic exendin‑4 reduced radial maze completion time versus vehicle.
In plain wordsIn rodents, chronic exendin‑4 reduced the time to solve a radial maze compared with vehicle.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseRadial maze completion time
Study
rodentn: not reported in source
adult rodents
Comparator
vehicle-treated controls
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · 1-2 weeksAs given in this study (rodent).
Source sentences
Summary
The time necessary to solve a radial maze task and the duration of immobility in the forced swim test were significantly reduced compared to respective vehicle groups if the animals had received exendin-4 during 1-2weeks before testing.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to assess the effects of exendin-4 treatment on hippocampus-associated cognitive and mood-related behavior in adult rodents.
Summary · context
To investigate potential effects of exendin-4 on hippocampal function, radial maze and forced swim test were employed.
Report a problemFND-2095113001
02AnimalAnimal study (in vivo)Efficacy outcome
In adult rodents, chronic exendin‑4 reduced forced swim immobility versus vehicle.
In plain wordsIn rodents, chronic exendin‑4 reduced immobility during forced swimming compared with vehicle.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseForced swim immobility after chronic treatment
Study
rodentn: not reported in source
adult rodents
Comparator
vehicle-treated controls
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
Dose not stated · 1-2 weeksAs given in this study (rodent).
Source sentences
Summary
The time necessary to solve a radial maze task and the duration of immobility in the forced swim test were significantly reduced compared to respective vehicle groups if the animals had received exendin-4 during 1-2weeks before testing.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to assess the effects of exendin-4 treatment on hippocampus-associated cognitive and mood-related behavior in adult rodents.
Summary · context
To investigate potential effects of exendin-4 on hippocampal function, radial maze and forced swim test were employed.
Report a problemFND-2095113002
03AnimalAnimal study (in vivo)Efficacy outcome
In adult rodents, a single exendin‑4 dose did not affect forced swim immobility versus vehicle.
In plain wordsIn rodents, a single exendin‑4 dose did not change immobility during forced swimming compared with vehicle.
Peptide
Exenatide (exendin-4)
Outcome
No significant changeForced swim immobility after single dose
Study
rodentn: not reported in source
adult rodents
Comparator
vehicle-treated controls
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
Dose not stated · single administration 1 h before challengeAs given in this study (rodent).
Source sentences
Summary
In contrast to the positive control imipramine, single administration of exendin-4 1h before the challenge in the forced swim test had no effect.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to assess the effects of exendin-4 treatment on hippocampus-associated cognitive and mood-related behavior in adult rodents.
Summary · context
To investigate potential effects of exendin-4 on hippocampal function, radial maze and forced swim test were employed.
Report a problemFND-2095113003
04AnimalAnimal study (in vivo)Mechanism
In adult rodents, chronic exendin‑4 increased hippocampal dentate gyrus bromodeoxyuridine incorporation versus vehicle.
In plain wordsIn rodents, chronic exendin‑4 increased a marker of DNA synthesis in the hippocampus compared with vehicle.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseDentate gyrus bromodeoxyuridine incorporation
Study
rodentn: not reported in source
adult rodents
Comparator
vehicle-treated controls
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 1-2 weeksAs given in this study (rodent).
Source sentences
Summary
Immunohistochemical analysis showed that the incorporation of bromodeoxyuridine, a marker for DNA synthesis, as well as doublecortin expression was increased in the hippocampal dentate gyrus following chronic treatment with exendin-4 compared to vehicle-treated controls.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to assess the effects of exendin-4 treatment on hippocampus-associated cognitive and mood-related behavior in adult rodents.
Summary · context
To investigate potential effects of exendin-4 on hippocampal function, radial maze and forced swim test were employed.
Report a problemFND-2095113004
05AnimalAnimal study (in vivo)Mechanism
In adult rodents, chronic exendin‑4 increased hippocampal dentate gyrus doublecortin expression versus vehicle.
In plain wordsIn rodents, chronic exendin‑4 increased doublecortin expression in the hippocampus compared with vehicle.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseDentate gyrus doublecortin expression
Study
rodentn: not reported in source
adult rodents
Comparator
vehicle-treated controls
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 1-2 weeksAs given in this study (rodent).
Source sentences
Summary
Immunohistochemical analysis showed that the incorporation of bromodeoxyuridine, a marker for DNA synthesis, as well as doublecortin expression was increased in the hippocampal dentate gyrus following chronic treatment with exendin-4 compared to vehicle-treated controls.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to assess the effects of exendin-4 treatment on hippocampus-associated cognitive and mood-related behavior in adult rodents.
Summary · context
To investigate potential effects of exendin-4 on hippocampal function, radial maze and forced swim test were employed.
Report a problemFND-2095113005
06AnimalAnimal study (in vivo)Mechanism
In adult rodents, exendin‑4 increased hippocampal Ki-67 mRNA expression versus vehicle.
In plain wordsIn rodents, exendin‑4 increased hippocampal Ki-67 gene expression compared with vehicle.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseKi-67 mRNA expression
Study
rodentn: not reported in source
adult rodents
Comparator
vehicle-treated controls
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 1-2 weeksAs given in this study (rodent).
Source sentences
Summary
The neurogenic effect of exendin-4 on hippocampus was confirmed by quantitative PCR showing an upregulation of mRNA expression for Ki-67, doublecortin and Mash-1.
3 context sentences(design, population, supporting numbers)
Summary · context
Immunohistochemical analysis showed that the incorporation of bromodeoxyuridine, a marker for DNA synthesis, as well as doublecortin expression was increased in the hippocampal dentate gyrus following chronic treatment with exendin-4 compared to vehicle-treated controls.
Summary · context
The aim of this study was to assess the effects of exendin-4 treatment on hippocampus-associated cognitive and mood-related behavior in adult rodents.
Summary · context
To investigate potential effects of exendin-4 on hippocampal function, radial maze and forced swim test were employed.
Report a problemFND-2095113006
07AnimalAnimal study (in vivo)Mechanism
In adult rodents, exendin‑4 increased hippocampal doublecortin mRNA expression versus vehicle.
In plain wordsIn rodents, exendin‑4 increased hippocampal doublecortin gene expression compared with vehicle.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseDoublecortin mRNA expression
Study
rodentn: not reported in source
adult rodents
Comparator
vehicle-treated controls
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 1-2 weeksAs given in this study (rodent).
Source sentences
Summary
The neurogenic effect of exendin-4 on hippocampus was confirmed by quantitative PCR showing an upregulation of mRNA expression for Ki-67, doublecortin and Mash-1.
3 context sentences(design, population, supporting numbers)
Summary · context
Immunohistochemical analysis showed that the incorporation of bromodeoxyuridine, a marker for DNA synthesis, as well as doublecortin expression was increased in the hippocampal dentate gyrus following chronic treatment with exendin-4 compared to vehicle-treated controls.
Summary · context
The aim of this study was to assess the effects of exendin-4 treatment on hippocampus-associated cognitive and mood-related behavior in adult rodents.
Summary · context
To investigate potential effects of exendin-4 on hippocampal function, radial maze and forced swim test were employed.
Report a problemFND-2095113007
08AnimalAnimal study (in vivo)Mechanism
In adult rodents, exendin‑4 increased hippocampal Mash-1 mRNA expression versus vehicle.
In plain wordsIn rodents, exendin‑4 increased hippocampal Mash-1 gene expression compared with vehicle.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseMash-1 mRNA expression
Study
rodentn: not reported in source
adult rodents
Comparator
vehicle-treated controls
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · 1-2 weeksAs given in this study (rodent).
Source sentences
Summary
The neurogenic effect of exendin-4 on hippocampus was confirmed by quantitative PCR showing an upregulation of mRNA expression for Ki-67, doublecortin and Mash-1.
3 context sentences(design, population, supporting numbers)
Summary · context
Immunohistochemical analysis showed that the incorporation of bromodeoxyuridine, a marker for DNA synthesis, as well as doublecortin expression was increased in the hippocampal dentate gyrus following chronic treatment with exendin-4 compared to vehicle-treated controls.
Summary · context
The aim of this study was to assess the effects of exendin-4 treatment on hippocampus-associated cognitive and mood-related behavior in adult rodents.
Summary · context
To investigate potential effects of exendin-4 on hippocampal function, radial maze and forced swim test were employed.
Report a problemFND-2095113008

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

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