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Study · Animal study (in vivo) · rat · 2002

4 results

Exendin 4 up-regulates expression of PDX 1 and hastens differentiation and maturation of human fetal pancreatic cells.

Movassat J, Beattie GM, Lopez AD, Hayek A

The Journal of clinical endocrinology and metabolism1 Oct 2002Cited by 70 (Europe PMC)

PMID12364473 (opens in a new tab)DOI10.1210/jc.2002-020137 (opens in a new tab)PepBankPUB-12364473
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with human fetal pancreatic grafts, exendin‑4 enabled glucose-induced human insulin release, while saline controls lacked a significant response.

    In plain wordsIn rats with human pancreatic grafts, exendin‑4 enabled insulin release after glucose, while saline controls lacked a significant response.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseGlucose-induced human insulin release
    Study

    ratn: not reported in source

    athymic rats with transplanted human fetal pancreatic ICCs
    Comparator
    saline-treated rats
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · intraperitoneal · 10 dAs given in this study (rat).

    Source sentences

    Summary
    In the exendin 4-treated rats (given ip during 10 d) 8 wk after the beginning of the treatment, insulin was released in response to glucose as detected by the measurement of circulating human C-peptide. In control (saline-treated) rats, the basal levels of human C-peptide did not change significantl…
    1 context sentence
    Summary · context
    We also tested the effects of exendin 4 in the glucose-induced insulin secretion of human ICCs transplanted under the kidney capsule of athymic rats.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with human fetal pancreatic grafts, exendin‑4 increased beta-cell numbers versus control rats.

    In plain wordsIn rats with human pancreatic grafts, exendin‑4 increased insulin-producing cell numbers versus control rats.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseGraft beta-cell number
    Study

    ratn: not reported in source

    athymic rats with transplanted human fetal pancreatic ICCs
    Comparator
    control rats
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · intraperitoneal · 10 dAs given in this study (rat).

    Source sentences

    Summary
    We found a significant increase in beta-cell number, compared with the control rats.
    2 context sentences
    Summary · context
    In these rats, serial sections of the kidney-bearing grafts were examined histologically for insulin containing cells.
    Summary · context
    We also tested the effects of exendin 4 in the glucose-induced insulin secretion of human ICCs transplanted under the kidney capsule of athymic rats. In the exendin 4-treated rats (given ip during 10 d) 8 wk after the beginning of the treatment, insulin was released in response to glucose as detecte…
  3. 03LabIn vitro (cells)Mechanism

    In human fetal pancreatic islet-like cell clusters, exendin‑4 stimulated PDX 1 expression.

    In plain wordsIn cells from human fetal pancreases, exendin‑4 increased PDX 1 expression.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreasePDX 1 expression
    Study

    humann: not reported in source

    human fetal pancreatic islet-like cell clusters
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our results show that the addition of exendin 4 to the culture media stimulates PDX 1 expression in ICCs as shown by immunofluorescence staining.
    1 context sentence
    Summary · context
    Here, we investigated the effect of exendin 4 in the growth and differentiation of beta-cells from undifferentiated precursors in islet-like cell clusters (ICCs) derived from human fetal pancreases.
  4. 04LabIn vitro (cells)Mechanism

    In human fetal pancreatic islet-like cell clusters, exendin‑4 did not significantly change insulin-positive cell numbers versus controls.

    In plain wordsIn cells from human fetal pancreases, exendin‑4 did not significantly change insulin-positive cell numbers versus controls.

    Peptide
    Exenatide (exendin-4)
    Outcome
    No significant changeInsulin-positive cell number
    Study

    humann: not reported in source

    human fetal pancreatic islet-like cell clusters
    Comparator
    controls
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The up-regulation of PDX 1 was not accompanied by changes in insulin expression because we did not find a significant difference in the number of insulin-positive cells in the exendin 4-treated ICCs, compared with controls.
    1 context sentence
    Summary · context
    Here, we investigated the effect of exendin 4 in the growth and differentiation of beta-cells from undifferentiated precursors in islet-like cell clusters (ICCs) derived from human fetal pancreases.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

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