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Study · Animal study (in vivo) · rat · 2016

8 results

Exendin-4 Enhances Motor Function Recovery via Promotion of Autophagy and Inhibition of Neuronal Apoptosis After Spinal Cord Injury in Rats.

Li HT, Zhao XZ, Zhang XR, Li G, Jia ZQ, Sun P, Wang JQ, Fan ZK, Lv G

Molecular neurobiology22 Jul 2015Cited by 74 (Europe PMC)

PMID26198566 (opens in a new tab)DOI10.1007/s12035-015-9327-7 (opens in a new tab)PepBankPUB-26198566
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats after spinal cord injury, exendin‑4 increased BBB locomotor scores, especially at 10 μg.

    In plain wordsIn rats after spinal cord injury, exendin‑4 improved movement scores, especially at 10 μg.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseBBB locomotor score
    Study

    ratn: not reported in source

    spinal cord injury in male Sprague Dawley rats
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    2.5 μg or 10 μg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Motor function evaluation with the Basso Beattie Bresnahan (BBB) locomotor rating scale indicated significantly increased scores (p < 0.01) in the Ex-4-treated groups, especially 10 μg, which demonstrated the neuroprotective effect of Ex-4 after SCI.
    2 context sentences
    Summary · context
    Seventy-two male Sprague Dawley rats were randomly assigned to sham, SCI, 2.5 μg Ex-4, and 10 μg Ex-4 groups.
    Summary · context
    Ex-4 was administered via intraperitoneal injection immediately after surgery.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats after spinal cord injury, exendin‑4 increased LC3-II expression.

    In plain wordsIn rats after spinal cord injury, exendin‑4 increased LC3-II expression.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseLC3-II expression
    Study

    ratn: not reported in source

    spinal cord injury in male Sprague Dawley rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 μg or 10 μg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    The light chain 3-II (LC3-II) and Beclin 1 protein expression determined via western blot and the number of autophagy-positive neurons via immunofluorescence double labeling were increased by Ex-4, which supports promotion of autophagy (p < 0.01).
    2 context sentences
    Summary · context
    Seventy-two male Sprague Dawley rats were randomly assigned to sham, SCI, 2.5 μg Ex-4, and 10 μg Ex-4 groups.
    Summary · context
    Ex-4 was administered via intraperitoneal injection immediately after surgery.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats after spinal cord injury, exendin‑4 increased Beclin 1 expression.

    In plain wordsIn rats after spinal cord injury, exendin‑4 increased Beclin 1 expression.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseBeclin 1 expression
    Study

    ratn: not reported in source

    spinal cord injury in male Sprague Dawley rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 μg or 10 μg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    The light chain 3-II (LC3-II) and Beclin 1 protein expression determined via western blot and the number of autophagy-positive neurons via immunofluorescence double labeling were increased by Ex-4, which supports promotion of autophagy (p < 0.01).
    2 context sentences
    Summary · context
    Seventy-two male Sprague Dawley rats were randomly assigned to sham, SCI, 2.5 μg Ex-4, and 10 μg Ex-4 groups.
    Summary · context
    Ex-4 was administered via intraperitoneal injection immediately after surgery.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats after spinal cord injury, exendin‑4 increased the number of autophagy-positive neurons.

    In plain wordsIn rats after spinal cord injury, exendin‑4 increased the number of neurons with autophagy.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseAutophagy-positive neurons
    Study

    ratn: not reported in source

    spinal cord injury in male Sprague Dawley rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 μg or 10 μg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    The light chain 3-II (LC3-II) and Beclin 1 protein expression determined via western blot and the number of autophagy-positive neurons via immunofluorescence double labeling were increased by Ex-4, which supports promotion of autophagy (p < 0.01).
    2 context sentences
    Summary · context
    Seventy-two male Sprague Dawley rats were randomly assigned to sham, SCI, 2.5 μg Ex-4, and 10 μg Ex-4 groups.
    Summary · context
    Ex-4 was administered via intraperitoneal injection immediately after surgery.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats after spinal cord injury, exendin‑4 significantly reduced caspase-3 protein levels.

    In plain wordsIn rats after spinal cord injury, exendin‑4 reduced caspase-3 protein levels.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseCaspase-3 protein
    Study

    ratn: not reported in source

    spinal cord injury in male Sprague Dawley rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 μg or 10 μg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    The caspase-3 protein level and neuronal apoptosis via transferase UTP nick end labeling (TUNEL)/NeuN/DAPI double labeling were significantly reduced in the Ex-4-treated groups, which indicates anti-apoptotic effects (p < 0.01).
    2 context sentences
    Summary · context
    Seventy-two male Sprague Dawley rats were randomly assigned to sham, SCI, 2.5 μg Ex-4, and 10 μg Ex-4 groups.
    Summary · context
    Ex-4 was administered via intraperitoneal injection immediately after surgery.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats after spinal cord injury, exendin‑4 significantly reduced neuronal apoptosis.

    In plain wordsIn rats after spinal cord injury, exendin‑4 reduced nerve cell death by apoptosis.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseNeuronal apoptosis
    Study

    ratn: not reported in source

    spinal cord injury in male Sprague Dawley rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 μg or 10 μg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    The caspase-3 protein level and neuronal apoptosis via transferase UTP nick end labeling (TUNEL)/NeuN/DAPI double labeling were significantly reduced in the Ex-4-treated groups, which indicates anti-apoptotic effects (p < 0.01).
    2 context sentences
    Summary · context
    Seventy-two male Sprague Dawley rats were randomly assigned to sham, SCI, 2.5 μg Ex-4, and 10 μg Ex-4 groups.
    Summary · context
    Ex-4 was administered via intraperitoneal injection immediately after surgery.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats after spinal cord injury, exendin‑4 significantly increased surviving neuron numbers.

    In plain wordsIn rats after spinal cord injury, exendin‑4 increased the number of surviving nerve cells.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseSurviving neurons
    Study

    ratn: not reported in source

    spinal cord injury in male Sprague Dawley rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 μg or 10 μg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Finally, histological assessment via Nissl staining demonstrated the Ex-4 groups exhibited a significantly greater number of surviving neurons and less cavity (p < 0.01).
    2 context sentences
    Summary · context
    Seventy-two male Sprague Dawley rats were randomly assigned to sham, SCI, 2.5 μg Ex-4, and 10 μg Ex-4 groups.
    Summary · context
    Ex-4 was administered via intraperitoneal injection immediately after surgery.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats after spinal cord injury, exendin‑4 significantly reduced cavity formation.

    In plain wordsIn rats after spinal cord injury, exendin‑4 reduced cavities in injured tissue.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseCavity formation
    Study

    ratn: not reported in source

    spinal cord injury in male Sprague Dawley rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 μg or 10 μg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Finally, histological assessment via Nissl staining demonstrated the Ex-4 groups exhibited a significantly greater number of surviving neurons and less cavity (p < 0.01).
    2 context sentences
    Summary · context
    Seventy-two male Sprague Dawley rats were randomly assigned to sham, SCI, 2.5 μg Ex-4, and 10 μg Ex-4 groups.
    Summary · context
    Ex-4 was administered via intraperitoneal injection immediately after surgery.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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