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Study · Animal study (in vivo) · mouse · 2012

3 results

Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21.

Müller TD, Sullivan LM, Habegger K, Yi CX, Kabra D, Grant E, Ottaway N, Krishna R, Holland J, Hembree J, Perez-Tilve D, Pfluger PT and 7 more

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DeGuzman MJ, Siladi ME, Kraynov VS, Axelrod DW, DiMarchi R, Pinkstaff JK, Tschöp MH

Journal of peptide science : an official publication of the European Peptide Society4 May 2012Cited by 126 (Europe PMC)

PMID22565812 (opens in a new tab)DOI10.1002/psc.2408 (opens in a new tab)PepBankPUB-22565812
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In obese mice, exendin‑4 blunted the hypothalamic counter-regulatory response to weight loss triggered by caloric restriction.

    In plain wordsIn obese mice, exendin‑4 blunted a brain response to weight loss compared with calorie restriction.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseHypothalamic counter-regulatory AgRP response
    Study

    mousen: not reported in source

    Diet-induced obese mice
    Comparator
    Caloric restriction
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Accordingly, we find that a hypothalamic counter-regulatory response to weight loss, assessed using changes in hypothalamic agouti related peptide (AgRP) levels, is triggered by caloric restriction, but blunted by treatment with exendin-4.

Studies that did not test the peptide alone2

In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Exenatide (exendin-4).

  1. 02AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Efficacy outcome

    In obese mice, enhanced leptin analogs with exendin‑4 restored leptin responsiveness after initial weight loss.

    In plain wordsIn obese mice, a leptin analog combined with exendin‑4 restored responsiveness to leptin after initial weight loss.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseLeptin responsiveness
    Study

    mousen: not reported in source

    Diet-induced obese mice
    Outcome group
    Receptor activity and mechanism · Metabolic and weight

    Source sentences

    Summary
    that, when administered in combination with exendin-4 or fibroblast growth factor 21 (FGF21), restores leptin responsiveness in DIO mice after an initial body weight loss of 30%.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

  2. 03AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Efficacy outcome

    In obese mice, enhanced leptin analogs with exendin‑4 increased weight loss compared with exendin‑4 alone.

    In plain wordsIn obese mice, a leptin analog with exendin‑4 produced more weight loss than exendin‑4 alone.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseBody weight
    Study

    mousen: not reported in source

    Diet-induced obese mice
    Comparator
    Exendin-4 monotherapy
    Outcome group
    Body weight · Metabolic and weight

    Source sentences

    Summary
    Using either combination, body weight loss was enhanced compared with either exendin-4 or FGF21 monotherapy, and leptin alone was sufficient to maintain the reduced body weight.
    1 context sentence
    Summary · context
    that, when administered in combination with exendin-4 or fibroblast growth factor 21 (FGF21), restores leptin responsiveness in DIO mice after an initial body weight loss of 30%.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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