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Study · Animal study (in vivo) · mouse · 2010

3 results

Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet.

Gault VA, Porter WD, Flatt PR, Hölscher C

International journal of obesity (2005)30 Mar 2010Cited by 78 (Europe PMC)

PMID20351729 (opens in a new tab)DOI10.1038/ijo.2010.59 (opens in a new tab)PepBankPUB-20351729
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In high-fat-fed mice, exendin‑4 improved metabolic control compared with saline vehicle.

    In plain wordsIn mice fed a high-fat diet, exendin‑4 improved metabolic control compared with saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseMetabolic control
    Study

    mousen: not reported in source

    high-fat diet-induced obesity
    Comparator
    saline vehicle
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    25 nmol kg(-1) twice daily · 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    In addition to improving metabolic control, exendin-4-treated mice exhibited a marked increase in recognition index highlighting improved learning and memory.
    1 context sentence
    Summary · context
    Mice fed a high-fat diet were treated with exendin-4 (25 nmol kg(-1) bodyweight; twice daily) or saline vehicle (0.9% (w/v) NaCl) over 21 days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In high-fat-fed mice, exendin‑4 increased recognition index, indicating improved learning and memory compared with saline vehicle.

    In plain wordsIn mice fed a high-fat diet, exendin‑4 improved a memory test score compared with saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseRecognition index
    Study

    mousen: not reported in source

    high-fat diet-induced obesity
    Comparator
    saline vehicle
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    25 nmol kg(-1) twice daily · 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    In addition to improving metabolic control, exendin-4-treated mice exhibited a marked increase in recognition index highlighting improved learning and memory.
    1 context sentence
    Summary · context
    Mice fed a high-fat diet were treated with exendin-4 (25 nmol kg(-1) bodyweight; twice daily) or saline vehicle (0.9% (w/v) NaCl) over 21 days.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In high-fat-fed mice, exendin‑4 restored hippocampal long-term potentiation eliminated by the diet.

    In plain wordsIn mice fed a high-fat diet, exendin‑4 restored hippocampal long-term potentiation compared with saline.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseHippocampal long-term potentiation
    Study

    mousen: not reported in source

    high-fat diet-induced obesity
    Comparator
    saline vehicle
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    25 nmol kg(-1) twice daily · 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    High-fat diet resulted in the elimination of in vivo electrophysiological long-term potentiation, which was rescued following exendin-4 treatment.
    1 context sentence
    Summary · context
    Mice fed a high-fat diet were treated with exendin-4 (25 nmol kg(-1) bodyweight; twice daily) or saline vehicle (0.9% (w/v) NaCl) over 21 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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