Exenatide alleviates mitochondrial dysfunction and cognitive impairment in the 5×FAD mouse model of Alzheimer's disease.

An J, Zhou Y, Zhang M, Xie Y, Ke S, Liu L, Pan X, Chen Z

Behavioural brain research10 May 2019Cited by 66 (Europe PMC)

PMID31082410DOI10.1016/j.bbr.2019.111932PepBankPUB-31082410

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In 5xFAD mice, exenatide prevented cognitive decline after treatment.
In plain wordsIn mice, exenatide prevented cognitive decline in a spatial memory test.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseSpatial memory decline
Study
mousen: not reported in source
5xFAD transgenic mice
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
100 μg/kg twice per day · 16 weeksAs given in this study (mouse).
Source sentences
Summary
Spatial memory test showed that exenatide administration (100 μg/kg twice per day) prevented cognitive decline after 16 weeks of treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
We conducted this study to explore the effects of exenatide (a GLP-1 receptor agonist) on β-amyloid plaque (Aβ)-induced cognitive impairment and mitochondrial dysfunction in 5xFAD transgenic mice.
Report a problemFND-3108241001
02AnimalAnimal study (in vivo)Efficacy outcome
In 5xFAD mice, exenatide alleviated hippocampal amyloid-beta deposition.
In plain wordsIn mice, exenatide reduced amyloid-beta deposits in the hippocampus.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseHippocampal amyloid deposition
Study
mousen: not reported in source
5xFAD transgenic mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
100 μg/kg twice per day · 16 weeksAs given in this study (mouse).
Source sentences
Summary
Aβ_1-42 deposition and synapse damage in the hippocampus was signiﬁcantly alleviated.
1 context sentence(design, population, supporting numbers)
Summary · context
We conducted this study to explore the effects of exenatide (a GLP-1 receptor agonist) on β-amyloid plaque (Aβ)-induced cognitive impairment and mitochondrial dysfunction in 5xFAD transgenic mice.
Report a problemFND-3108241002
03AnimalAnimal study (in vivo)Efficacy outcome
In 5xFAD mice, exenatide alleviated hippocampal synapse damage.
In plain wordsIn mice, exenatide reduced synapse damage in the hippocampus.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseHippocampal synapse damage
Study
mousen: not reported in source
5xFAD transgenic mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
100 μg/kg twice per day · 16 weeksAs given in this study (mouse).
Source sentences
Summary
Aβ_1-42 deposition and synapse damage in the hippocampus was signiﬁcantly alleviated.
1 context sentence(design, population, supporting numbers)
Summary · context
We conducted this study to explore the effects of exenatide (a GLP-1 receptor agonist) on β-amyloid plaque (Aβ)-induced cognitive impairment and mitochondrial dysfunction in 5xFAD transgenic mice.
Report a problemFND-3108241003
04AnimalAnimal study (in vivo)Efficacy outcome
In 5xFAD mice, exenatide improved mitochondrial morphology.
In plain wordsIn mice, exenatide improved mitochondrial morphology.
Peptide
Exenatide (exendin-4)
Outcome
Direction not reportedMitochondrial morphology
Study
mousen: not reported in source
5xFAD transgenic mice
Outcome group
Mitochondrial function · Nervous system and cognition
Studied dose
100 μg/kg twice per day · 16 weeksAs given in this study (mouse).
Source sentences
Summary
Furthermore, exenatide treatment can improve mitochondrial morphology, relieve oxidative damage, correct mitochondrial energy crisis, and normalize mitochondrial dynamics.
1 context sentence(design, population, supporting numbers)
Summary · context
We conducted this study to explore the effects of exenatide (a GLP-1 receptor agonist) on β-amyloid plaque (Aβ)-induced cognitive impairment and mitochondrial dysfunction in 5xFAD transgenic mice.
Report a problemFND-3108241004
05AnimalAnimal study (in vivo)Efficacy outcome
In 5xFAD mice, exenatide relieved oxidative damage.
In plain wordsIn mice, exenatide relieved oxidative damage.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseOxidative damage
Study
mousen: not reported in source
5xFAD transgenic mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
100 μg/kg twice per day · 16 weeksAs given in this study (mouse).
Source sentences
Summary
Furthermore, exenatide treatment can improve mitochondrial morphology, relieve oxidative damage, correct mitochondrial energy crisis, and normalize mitochondrial dynamics.
2 context sentences(design, population, supporting numbers)
Summary · context
We conducted this study to explore the effects of exenatide (a GLP-1 receptor agonist) on β-amyloid plaque (Aβ)-induced cognitive impairment and mitochondrial dysfunction in 5xFAD transgenic mice.
Summary · context
Spatial memory test showed that exenatide administration (100 μg/kg twice per day) prevented cognitive decline after 16 weeks of treatment.
Report a problemFND-3108241005
06AnimalAnimal study (in vivo)Efficacy outcome
In 5xFAD mice, exenatide corrected the mitochondrial energy crisis.
In plain wordsIn mice, exenatide corrected the mitochondrial energy crisis.
Peptide
Exenatide (exendin-4)
Outcome
Direction not reportedMitochondrial energy crisis
Study
mousen: not reported in source
5xFAD transgenic mice
Outcome group
Mitochondrial function · Nervous system and cognition
Studied dose
100 μg/kg twice per day · 16 weeksAs given in this study (mouse).
Source sentences
Summary
Furthermore, exenatide treatment can improve mitochondrial morphology, relieve oxidative damage, correct mitochondrial energy crisis, and normalize mitochondrial dynamics.
2 context sentences(design, population, supporting numbers)
Summary · context
We conducted this study to explore the effects of exenatide (a GLP-1 receptor agonist) on β-amyloid plaque (Aβ)-induced cognitive impairment and mitochondrial dysfunction in 5xFAD transgenic mice.
Summary · context
Spatial memory test showed that exenatide administration (100 μg/kg twice per day) prevented cognitive decline after 16 weeks of treatment.
Report a problemFND-3108241006
07AnimalAnimal study (in vivo)Efficacy outcome
In 5xFAD mice, exenatide normalized mitochondrial dynamics.
In plain wordsIn mice, exenatide normalized mitochondrial dynamics.
Peptide
Exenatide (exendin-4)
Outcome
Direction not reportedMitochondrial dynamics
Study
mousen: not reported in source
5xFAD transgenic mice
Outcome group
Mitochondrial function · Nervous system and cognition
Studied dose
100 μg/kg twice per day · 16 weeksAs given in this study (mouse).
Source sentences
Summary
Furthermore, exenatide treatment can improve mitochondrial morphology, relieve oxidative damage, correct mitochondrial energy crisis, and normalize mitochondrial dynamics.
2 context sentences(design, population, supporting numbers)
Summary · context
We conducted this study to explore the effects of exenatide (a GLP-1 receptor agonist) on β-amyloid plaque (Aβ)-induced cognitive impairment and mitochondrial dysfunction in 5xFAD transgenic mice.
Summary · context
Spatial memory test showed that exenatide administration (100 μg/kg twice per day) prevented cognitive decline after 16 weeks of treatment.
Report a problemFND-3108241007

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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Exenatide alleviates mitochondrial dysfunction and cognitive impairment in the 5×FAD mouse model of Alzheimer's disease.

Summary

Results from this study7

Version history

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