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Study · Animal study (in vivo) · mouse · 2005

7 results

Enhanced expression of PDX-1 and Ngn3 by exendin-4 during beta cell regeneration in STZ-treated mice.

Kodama S, Toyonaga T, Kondo T, Matsumoto K, Tsuruzoe K, Kawashima J, Goto H, Kume K, Kume S, Sakakida M, Araki E

Biochemical and biophysical research communications1 Feb 2005Cited by 66 (Europe PMC)

PMID15652518 (opens in a new tab)DOI10.1016/j.bbrc.2004.12.120 (opens in a new tab)PepBankPUB-15652518
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice, PDX-1-positive cells appeared in ducts and islet-like clusters with exendin‑4, versus clusters alone after streptozotocin alone.

    In plain wordsIn mice, exendin‑4 plus streptozotocin showed PDX-1-positive cells in ducts and clusters, versus clusters alone with streptozotocin.

    Peptide
    Exenatide (exendin-4)
    Outcome
    MixedPDX-1-positive cell localization
    Study

    Mousen: not reported in source

    Streptozotocin-treated mice
    Comparator
    Streptozotocin alone
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    PDX-1-positive cells appeared only in islet-like cell clusters (ICCs) in STZ group, but they appeared both in ducts and ICCs in STZ + Ex-4 group.
    1 context sentence
    Summary · context
    To address the mechanism of beta cell regeneration, mice were treated with streptozotocin (STZ group) or streptozotocin and exendin-4 (STZ + Ex-4 group), and the expression of PDX-1, Ngn3, insulin, IRS-2, and Foxo1 was investigated.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In streptozotocin-treated mice, exendin‑4 upregulated PDX-1 expression.

    In plain wordsIn mice treated with streptozotocin, exendin‑4 increased PDX-1 expression.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreasePDX-1 expression
    Study

    Mousen: not reported in source

    Streptozotocin-treated mice
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exendin-4 upregulated PDX-1 expression which paralleled increased IRS-2 expression and translocation of Foxo1 from nucleus to cytoplasm.
    1 context sentence
    Summary · context
    To address the mechanism of beta cell regeneration, mice were treated with streptozotocin (STZ group) or streptozotocin and exendin-4 (STZ + Ex-4 group), and the expression of PDX-1, Ngn3, insulin, IRS-2, and Foxo1 was investigated.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In streptozotocin-treated mice, exendin‑4-induced PDX-1 upregulation paralleled increased IRS-2 expression.

    In plain wordsIn mice, increased PDX-1 during exendin‑4 treatment accompanied increased IRS-2 expression.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseIRS-2 expression
    Study

    Mousen: not reported in source

    Streptozotocin-treated mice
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exendin-4 upregulated PDX-1 expression which paralleled increased IRS-2 expression and translocation of Foxo1 from nucleus to cytoplasm.
    1 context sentence
    Summary · context
    To address the mechanism of beta cell regeneration, mice were treated with streptozotocin (STZ group) or streptozotocin and exendin-4 (STZ + Ex-4 group), and the expression of PDX-1, Ngn3, insulin, IRS-2, and Foxo1 was investigated.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In streptozotocin-treated mice, exendin‑4-induced PDX-1 upregulation paralleled Foxo1 translocation from nucleus to cytoplasm.

    In plain wordsIn mice, increased PDX-1 during exendin‑4 treatment accompanied Foxo1 movement from the nucleus to the cytoplasm.

    Peptide
    Exenatide (exendin-4)
    Outcome
    Not applicableFoxo1 translocation
    Study

    Mousen: not reported in source

    Streptozotocin-treated mice
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exendin-4 upregulated PDX-1 expression which paralleled increased IRS-2 expression and translocation of Foxo1 from nucleus to cytoplasm.
    1 context sentence
    Summary · context
    To address the mechanism of beta cell regeneration, mice were treated with streptozotocin (STZ group) or streptozotocin and exendin-4 (STZ + Ex-4 group), and the expression of PDX-1, Ngn3, insulin, IRS-2, and Foxo1 was investigated.

Studies that did not test the peptide alone3

In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Exenatide (exendin-4).

  1. 05AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Mechanism

    In the mouse regeneration study, PDX-1 mRNA showed biphasic upregulation without a stated exendin‑4-specific contrast.

    In plain wordsIn mice, PDX-1 gene expression increased in two phases, without a stated effect specific to exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseBiphasic PDX-1 mRNA expression
    Study

    Mousen: not reported in source

    Streptozotocin-treated mice
    Outcome group
    Receptor activity and mechanism · Metabolic and weight

    Source sentences

    Summary
    PDX-1 mRNA was upregulated biphasically and induction of Ngn3 mRNA occurred shortly after the first increase of PDX-1 expression, a pattern similar to that observed during embryogenesis.
    1 context sentence
    Summary · context
    To address the mechanism of beta cell regeneration, mice were treated with streptozotocin (STZ group) or streptozotocin and exendin-4 (STZ + Ex-4 group), and the expression of PDX-1, Ngn3, insulin, IRS-2, and Foxo1 was investigated.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

  2. 06AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Mechanism

    In the mouse regeneration study, Ngn3 mRNA induction followed the first PDX-1 rise without a stated exendin‑4-specific contrast.

    In plain wordsIn mice, Ngn3 gene expression followed the first PDX-1 rise, without a stated effect specific to exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseNgn3 mRNA induction
    Study

    Mousen: not reported in source

    Streptozotocin-treated mice
    Outcome group
    Receptor activity and mechanism · Metabolic and weight

    Source sentences

    Summary
    PDX-1 mRNA was upregulated biphasically and induction of Ngn3 mRNA occurred shortly after the first increase of PDX-1 expression, a pattern similar to that observed during embryogenesis.
    1 context sentence
    Summary · context
    To address the mechanism of beta cell regeneration, mice were treated with streptozotocin (STZ group) or streptozotocin and exendin-4 (STZ + Ex-4 group), and the expression of PDX-1, Ngn3, insulin, IRS-2, and Foxo1 was investigated.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

  3. 07AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Mechanism

    In the mouse regeneration study, Ngn3-positive cells appeared in islet-like clusters but not ducts, without a stated exendin‑4-specific contrast.

    In plain wordsIn mice, Ngn3-positive cells appeared in islet-like clusters, not ducts, without a stated effect specific to exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    Not applicableNgn3-positive cell localization
    Study

    Mousen: not reported in source

    Streptozotocin-treated mice
    Outcome group
    Receptor activity and mechanism · Metabolic and weight

    Source sentences

    Summary
    Ngn3-positive cells emerged in ICCs but not in ducts.
    1 context sentence
    Summary · context
    To address the mechanism of beta cell regeneration, mice were treated with streptozotocin (STZ group) or streptozotocin and exendin-4 (STZ + Ex-4 group), and the expression of PDX-1, Ngn3, insulin, IRS-2, and Foxo1 was investigated.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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