Skip to content

Study · Animal study (in vivo) · mouse · 2008

13 results

Exendin-4 stimulation of cyclin A2 in beta-cell proliferation.

Song WJ, Schreiber WE, Zhong E, Liu FF, Kornfeld BD, Wondisford FE, Hussain MA

Diabetes10 Jun 2008Cited by 74 (Europe PMC)

PMID18544709 (opens in a new tab)PMCIDPMC2518488 (opens in a new tab)DOI10.2337/db07-1541 (opens in a new tab)PepBankPUB-18544709
Read at sourcePubMedAsk about this study
Jump to 13 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study13

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice, exendin‑4 increased beta-cell proliferation.

    In plain wordsIn mice, exendin‑4 increased beta-cell proliferation.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseBeta-cell proliferation
    Study

    mousen: not reported in source

    mouse islets
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mice treated with exendin-4 showed increased beta-cell proliferation, elevated islet protein levels of cyclin A2 with unchanged D-type cyclins, elevated PDX-1 and Skp2 levels, and reduced p27 levels.
    2 context sentences
    Summary · context
    Changes in islet protein levels of cyclins and of two critical cell cycle regulators cyclin kinase inhibitor p27 and S-phase kinase-associated protein 2 (Skp2) were assessed in mice treated with exendin-4 and in a mouse model with specific upregulation of nuclear cAMP signaling exhibiting increased…
    Summary · context
    Because cyclin A2 was stimulated by cAMP, we assessed the role of cylcin A2 in cell cycle progression in Min6 and isolated islet beta-cells.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, exendin‑4 elevated islet cyclin A2 protein levels.

    In plain wordsIn mice, exendin‑4 increased islet cyclin A2 protein.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseIslet cyclin A2 protein
    Study

    mousen: not reported in source

    mouse islets
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mice treated with exendin-4 showed increased beta-cell proliferation, elevated islet protein levels of cyclin A2 with unchanged D-type cyclins, elevated PDX-1 and Skp2 levels, and reduced p27 levels.
    2 context sentences
    Summary · context
    Changes in islet protein levels of cyclins and of two critical cell cycle regulators cyclin kinase inhibitor p27 and S-phase kinase-associated protein 2 (Skp2) were assessed in mice treated with exendin-4 and in a mouse model with specific upregulation of nuclear cAMP signaling exhibiting increased…
    Summary · context
    Because cyclin A2 was stimulated by cAMP, we assessed the role of cylcin A2 in cell cycle progression in Min6 and isolated islet beta-cells.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, exendin‑4 did not change islet D-type cyclin levels.

    In plain wordsIn mice, exendin‑4 did not change islet D-type cyclin levels.

    Peptide
    Exenatide (exendin-4)
    Outcome
    No significant changeIslet D-type cyclins
    Study

    mousen: not reported in source

    mouse islets
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mice treated with exendin-4 showed increased beta-cell proliferation, elevated islet protein levels of cyclin A2 with unchanged D-type cyclins, elevated PDX-1 and Skp2 levels, and reduced p27 levels.
    2 context sentences
    Summary · context
    Changes in islet protein levels of cyclins and of two critical cell cycle regulators cyclin kinase inhibitor p27 and S-phase kinase-associated protein 2 (Skp2) were assessed in mice treated with exendin-4 and in a mouse model with specific upregulation of nuclear cAMP signaling exhibiting increased…
    Summary · context
    Because cyclin A2 was stimulated by cAMP, we assessed the role of cylcin A2 in cell cycle progression in Min6 and isolated islet beta-cells.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice, exendin‑4 elevated islet PDX-1 levels.

    In plain wordsIn mice, exendin‑4 increased islet PDX-1 levels.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseIslet PDX-1
    Study

    mousen: not reported in source

    mouse islets
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mice treated with exendin-4 showed increased beta-cell proliferation, elevated islet protein levels of cyclin A2 with unchanged D-type cyclins, elevated PDX-1 and Skp2 levels, and reduced p27 levels.
    2 context sentences
    Summary · context
    Changes in islet protein levels of cyclins and of two critical cell cycle regulators cyclin kinase inhibitor p27 and S-phase kinase-associated protein 2 (Skp2) were assessed in mice treated with exendin-4 and in a mouse model with specific upregulation of nuclear cAMP signaling exhibiting increased…
    Summary · context
    Because cyclin A2 was stimulated by cAMP, we assessed the role of cylcin A2 in cell cycle progression in Min6 and isolated islet beta-cells.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice, exendin‑4 elevated islet Skp2 levels.

    In plain wordsIn mice, exendin‑4 increased islet Skp2 levels.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseIslet Skp2
    Study

    mousen: not reported in source

    mouse islets
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mice treated with exendin-4 showed increased beta-cell proliferation, elevated islet protein levels of cyclin A2 with unchanged D-type cyclins, elevated PDX-1 and Skp2 levels, and reduced p27 levels.
    2 context sentences
    Summary · context
    Changes in islet protein levels of cyclins and of two critical cell cycle regulators cyclin kinase inhibitor p27 and S-phase kinase-associated protein 2 (Skp2) were assessed in mice treated with exendin-4 and in a mouse model with specific upregulation of nuclear cAMP signaling exhibiting increased…
    Summary · context
    Because cyclin A2 was stimulated by cAMP, we assessed the role of cylcin A2 in cell cycle progression in Min6 and isolated islet beta-cells.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice, exendin‑4 reduced islet p27 levels.

    In plain wordsIn mice, exendin‑4 reduced islet p27 levels.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseIslet p27
    Study

    mousen: not reported in source

    mouse islets
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mice treated with exendin-4 showed increased beta-cell proliferation, elevated islet protein levels of cyclin A2 with unchanged D-type cyclins, elevated PDX-1 and Skp2 levels, and reduced p27 levels.
    2 context sentences
    Summary · context
    Changes in islet protein levels of cyclins and of two critical cell cycle regulators cyclin kinase inhibitor p27 and S-phase kinase-associated protein 2 (Skp2) were assessed in mice treated with exendin-4 and in a mouse model with specific upregulation of nuclear cAMP signaling exhibiting increased…
    Summary · context
    Because cyclin A2 was stimulated by cAMP, we assessed the role of cylcin A2 in cell cycle progression in Min6 and isolated islet beta-cells.
  7. 07LabEx vivo tissueMechanism

    In cultured mouse islets, exendin‑4 increased cyclin A2.

    In plain wordsIn lab tests, exendin‑4 increased cyclin A2 in cultured mouse islets.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseCultured-islet cyclin A2
    Study

    mousen: not reported in source

    cultured mouse islets
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In cultured islets, exendin-4 increased cyclin A2 and Skp2 and reduced p27.
    2 context sentences
    Summary · context
    Changes in islet protein levels of cyclins and of two critical cell cycle regulators cyclin kinase inhibitor p27 and S-phase kinase-associated protein 2 (Skp2) were assessed in mice treated with exendin-4 and in a mouse model with specific upregulation of nuclear cAMP signaling exhibiting increased…
    Summary · context
    Because cyclin A2 was stimulated by cAMP, we assessed the role of cylcin A2 in cell cycle progression in Min6 and isolated islet beta-cells.
  8. 08LabEx vivo tissueMechanism

    In cultured mouse islets, exendin‑4 increased Skp2.

    In plain wordsIn lab tests, exendin‑4 increased Skp2 in cultured mouse islets.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseCultured-islet Skp2
    Study

    mousen: not reported in source

    cultured mouse islets
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In cultured islets, exendin-4 increased cyclin A2 and Skp2 and reduced p27.
    2 context sentences
    Summary · context
    Changes in islet protein levels of cyclins and of two critical cell cycle regulators cyclin kinase inhibitor p27 and S-phase kinase-associated protein 2 (Skp2) were assessed in mice treated with exendin-4 and in a mouse model with specific upregulation of nuclear cAMP signaling exhibiting increased…
    Summary · context
    Because cyclin A2 was stimulated by cAMP, we assessed the role of cylcin A2 in cell cycle progression in Min6 and isolated islet beta-cells.
  9. 09LabEx vivo tissueMechanism

    In cultured mouse islets, exendin‑4 reduced p27.

    In plain wordsIn lab tests, exendin‑4 reduced p27 in cultured mouse islets.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseCultured-islet p27
    Study

    mousen: not reported in source

    cultured mouse islets
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In cultured islets, exendin-4 increased cyclin A2 and Skp2 and reduced p27.
    2 context sentences
    Summary · context
    Changes in islet protein levels of cyclins and of two critical cell cycle regulators cyclin kinase inhibitor p27 and S-phase kinase-associated protein 2 (Skp2) were assessed in mice treated with exendin-4 and in a mouse model with specific upregulation of nuclear cAMP signaling exhibiting increased…
    Summary · context
    Because cyclin A2 was stimulated by cAMP, we assessed the role of cylcin A2 in cell cycle progression in Min6 and isolated islet beta-cells.
  10. 10LabIn vitro (cells)Mechanism

    In beta-cells, exendin‑4 stimulated cyclin A2 promoter activity through the cAMP-CREB pathway.

    In plain wordsIn cells, exendin‑4 stimulated cyclin A2 promoter activity through a cAMP pathway.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseCyclin A2 promoter activity
    Study

    mousen: not reported in source

    beta-cells
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exendin-4 stimulated cyclin A2 promoter activity via the cAMP-cAMP response element binding protein pathway.
    2 context sentences
    Summary · context
    Changes in islet protein levels of cyclins and of two critical cell cycle regulators cyclin kinase inhibitor p27 and S-phase kinase-associated protein 2 (Skp2) were assessed in mice treated with exendin-4 and in a mouse model with specific upregulation of nuclear cAMP signaling exhibiting increased…
    Summary · context
    Because cyclin A2 was stimulated by cAMP, we assessed the role of cylcin A2 in cell cycle progression in Min6 and isolated islet beta-cells.

Studies that did not test the peptide alone3

In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Exenatide (exendin-4).

  1. 11LabNot a test of Exenatide (exendin-4) aloneIn vitro (cells)Mechanism

    In Min6 cells, cyclin A2 knockdown prevented exendin‑4-stimulated proliferation.

    In plain wordsIn cells, cyclin A2 knockdown prevented proliferation stimulated by exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseExendin-4-stimulated proliferation after cyclin A2 knockdown
    Study

    mousen: not reported in source

    Min6 cells with cyclin A2 knockdown
    Outcome group
    Receptor activity and mechanism · Metabolic and weight

    Source sentences

    Summary
    In Min6 cells, cyclin A2 knockdown prevented exendin-4-stimulated proliferation.
    2 context sentences
    Summary · context
    Changes in islet protein levels of cyclins and of two critical cell cycle regulators cyclin kinase inhibitor p27 and S-phase kinase-associated protein 2 (Skp2) were assessed in mice treated with exendin-4 and in a mouse model with specific upregulation of nuclear cAMP signaling exhibiting increased…
    Summary · context
    Because cyclin A2 was stimulated by cAMP, we assessed the role of cylcin A2 in cell cycle progression in Min6 and isolated islet beta-cells.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

  2. 12LabNot a test of Exenatide (exendin-4) aloneIn vitro (cells)Mechanism

    In beta-cells, PDX-1 knockdown reduced exendin‑4-stimulated cAMP synthesis.

    In plain wordsIn cells, PDX-1 knockdown reduced cAMP synthesis stimulated by exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseExendin-4-stimulated cAMP synthesis after PDX-1 knockdown
    Study

    mousen: not reported in source

    beta-cells with PDX-1 knockdown
    Outcome group
    Receptor activity and mechanism · Metabolic and weight

    Source sentences

    Summary
    PDX-1 knockdown reduced exendin-4-stimulated cAMP synthesis and cyclin A2 transcription.
    2 context sentences
    Summary · context
    Changes in islet protein levels of cyclins and of two critical cell cycle regulators cyclin kinase inhibitor p27 and S-phase kinase-associated protein 2 (Skp2) were assessed in mice treated with exendin-4 and in a mouse model with specific upregulation of nuclear cAMP signaling exhibiting increased…
    Summary · context
    Because cyclin A2 was stimulated by cAMP, we assessed the role of cylcin A2 in cell cycle progression in Min6 and isolated islet beta-cells.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

  3. 13LabNot a test of Exenatide (exendin-4) aloneIn vitro (cells)Mechanism

    In beta-cells, PDX-1 knockdown reduced exendin‑4-stimulated cyclin A2 transcription.

    In plain wordsIn cells, PDX-1 knockdown reduced cyclin A2 transcription stimulated by exendin‑4.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseExendin-4-stimulated cyclin A2 transcription after PDX-1 knockdown
    Study

    mousen: not reported in source

    beta-cells with PDX-1 knockdown
    Outcome group
    Receptor activity and mechanism · Metabolic and weight

    Source sentences

    Summary
    PDX-1 knockdown reduced exendin-4-stimulated cAMP synthesis and cyclin A2 transcription.
    2 context sentences
    Summary · context
    Changes in islet protein levels of cyclins and of two critical cell cycle regulators cyclin kinase inhibitor p27 and S-phase kinase-associated protein 2 (Skp2) were assessed in mice treated with exendin-4 and in a mouse model with specific upregulation of nuclear cAMP signaling exhibiting increased…
    Summary · context
    Because cyclin A2 was stimulated by cAMP, we assessed the role of cylcin A2 in cell cycle progression in Min6 and isolated islet beta-cells.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.