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Study · Animal study (in vivo) · mouse · 2015

5 results

The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice.

Sørensen G, Reddy IA, Weikop P, Graham DL, Stanwood GD, Wortwein G, Galli A, Fink-Jensen A

Physiology & behavior11 Jun 2015Cited by 125 (Europe PMC)

PMID26072178 (opens in a new tab)PMCIDPMC4668599 (opens in a new tab)DOI10.1016/j.physbeh.2015.06.013 (opens in a new tab)PepBankPUB-26072178
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, exendin‑4 receptor stimulation reduced acute cocaine self-administration.

    In plain wordsIn mice, exendin‑4 reduced acute cocaine self-administration.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseAcute cocaine self-administration
    Study

    mousen: not reported in source

    cocaine exposure
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    Dose not stated · peripheral administrationAs given in this study (mouse).

    Source sentences

    Summary
    Here, we report that GLP-1 receptor stimulation reduces acute and chronic cocaine self-administration and attenuates cocaine-induced hyperlocomotion.
    1 context sentence
    Summary · context
    we decided to investigate the effect of the GLP-1 analogue exendin-4 on cocaine- and dopamine D1-receptor agonist-induced hyperlocomotion, on acute and chronic cocaine self-administration, on cocaine-induced striatal dopamine release in mice and on cocaine-induced c-fos activation.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, exendin‑4 receptor stimulation reduced chronic cocaine self-administration.

    In plain wordsIn mice, exendin‑4 reduced chronic cocaine self-administration.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseChronic cocaine self-administration
    Study

    mousen: not reported in source

    cocaine exposure
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    Dose not stated · peripheral administrationAs given in this study (mouse).

    Source sentences

    Summary
    Here, we report that GLP-1 receptor stimulation reduces acute and chronic cocaine self-administration and attenuates cocaine-induced hyperlocomotion.
    1 context sentence
    Summary · context
    we decided to investigate the effect of the GLP-1 analogue exendin-4 on cocaine- and dopamine D1-receptor agonist-induced hyperlocomotion, on acute and chronic cocaine self-administration, on cocaine-induced striatal dopamine release in mice and on cocaine-induced c-fos activation.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, exendin‑4 receptor stimulation attenuated cocaine-induced hyperlocomotion.

    In plain wordsIn mice, exendin‑4 reduced excessive movement caused by cocaine.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseCocaine-induced hyperlocomotion
    Study

    mousen: not reported in source

    cocaine exposure
    Outcome group
    Addiction, withdrawal and alcohol intake · Nervous system and cognition
    Studied dose
    Dose not stated · peripheral administrationAs given in this study (mouse).

    Source sentences

    Summary
    Here, we report that GLP-1 receptor stimulation reduces acute and chronic cocaine self-administration and attenuates cocaine-induced hyperlocomotion.
    1 context sentence
    Summary · context
    we decided to investigate the effect of the GLP-1 analogue exendin-4 on cocaine- and dopamine D1-receptor agonist-induced hyperlocomotion, on acute and chronic cocaine self-administration, on cocaine-induced striatal dopamine release in mice and on cocaine-induced c-fos activation.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice, peripheral exendin‑4 reduced cocaine-induced elevation of striatal dopamine.

    In plain wordsIn mice, exendin‑4 reduced the rise in striatal dopamine caused by cocaine.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseCocaine-induced striatal dopamine elevation
    Study

    mousen: not reported in source

    cocaine exposure
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · peripheral administrationAs given in this study (mouse).

    Source sentences

    Summary
    In addition, we show that peripheral administration of exendin-4 reduces cocaine-induced elevation of striatal dopamine levels and striatal c-fos expression implicating central GLP-1 receptors in these responses.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice, peripheral exendin‑4 reduced cocaine-induced striatal c-fos expression.

    In plain wordsIn mice, exendin‑4 reduced striatal c-fos expression caused by cocaine.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseStriatal c-fos expression
    Study

    mousen: not reported in source

    cocaine exposure
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · peripheral administrationAs given in this study (mouse).

    Source sentences

    Summary
    In addition, we show that peripheral administration of exendin-4 reduces cocaine-induced elevation of striatal dopamine levels and striatal c-fos expression implicating central GLP-1 receptors in these responses.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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