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Study · Animal study (in vivo) · rat · 2012

4 results

Exendin-4 decreases amphetamine-induced locomotor activity.

Erreger K, Davis AR, Poe AM, Greig NH, Stanwood GD, Galli A

Physiology & behavior19 Mar 2012Cited by 89 (Europe PMC)

PMID22465309 (opens in a new tab)PMCIDPMC3348974 (opens in a new tab)DOI10.1016/j.physbeh.2012.03.014 (opens in a new tab)PepBankPUB-22465309
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, acute exendin‑4 decreased basal locomotor activity.

    In plain wordsIn rats, exendin‑4 reduced baseline movement.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseBasal locomotor activity
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We report that in rats a single acute administration of Ex-4 decreases both basal locomotor activity as well as AMPH-induced locomotor activity.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, acute exendin‑4 decreased amphetamine-induced locomotor activity.

    In plain wordsIn rats, exendin‑4 reduced movement induced by amphetamine.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseAmphetamine-induced locomotor activity
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We report that in rats a single acute administration of Ex-4 decreases both basal locomotor activity as well as AMPH-induced locomotor activity.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In rats, exendin‑4 did not induce anxiety-related behavioral responses.

    In plain wordsIn rats, exendin‑4 did not induce anxiety-related behavior.

    Peptide
    Exenatide (exendin-4)
    Outcome
    No significant changeAnxiety behavior
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Ex-4 did not induce behavioral responses reflecting anxiety or aversion.
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In rats, exendin‑4 did not induce aversion-related behavioral responses.

    In plain wordsIn rats, exendin‑4 did not induce aversion-related behavior.

    Peptide
    Exenatide (exendin-4)
    Outcome
    No significant changeAversion behavior
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Ex-4 did not induce behavioral responses reflecting anxiety or aversion.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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