Elamipretide (SS-31) studies: 372 papers with results
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- Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.
Zhao W · Journal of neuroinflammation · 2019
Animal study (in vivo) · mouse · 6 results
- ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes.
Ducasa GM · The Journal of clinical investigation · 2019
Animal study (in vivo) · mouse · 3 results
- Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice.
Siegel MP · Aging cell · 2013
Animal study (in vivo) · mouse · 9 results
- Mitochondria Protection after Acute Ischemia Prevents Prolonged Upregulation of IL-1β and IL-18 and Arrests CKD.
Szeto HH · Journal of the American Society of Nephrology : JASN · 2017
Animal study (in vivo) · rat · 7 results
- A novel cell-permeable antioxidant peptide, SS31, attenuates ischemic brain injury by down-regulating CD36.
Cho S · The Journal of biological chemistry · 2007
Animal study (in vivo) · mouse · 7 results
- Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity.
Yang L · Antioxidants & redox signaling · 2009
Animal study (in vivo) · mouse · 6 results
- Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis.
Petri S · Journal of neurochemistry · 2006
Animal study (in vivo) · mouse · 5 results
- Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice.
Campbell MD · Free radical biology & medicine · 2019
Animal study (in vivo) · mouse · 9 results
- Enhanced efficiency of mitochondria-targeted peptide SS-31 for acute kidney injury by pH-responsive and AKI-kidney targeted nanopolyplexes.
Liu D · Biomaterials · 2019
Animal study (in vivo) · mouse · 7 results
- Reduction of ischemia/reperfusion injury with bendavia, a mitochondria-targeting cytoprotective Peptide.
Kloner RA · Journal of the American Heart Association · 2012
Animal study (in vivo) · rabbit and sheep · 8 results
- Global proteomics and pathway analysis of pressure-overload-induced heart failure and its attenuation by mitochondrial-targeted peptides.
Dai DF · Circulation. Heart failure · 2013
Animal study (in vivo) · 5 results
- Catalpol ameliorates depressive-like behaviors in CUMS mice via oxidative stress-mediated NLRP3 inflammasome and neuroinflammation.
Wang YL · Translational psychiatry · 2021
Animal study (in vivo) · mouse · 3 results
- Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy.
Sakellariou GK · Scientific reports · 2016
Animal study (in vivo) · mouse · 3 results
- Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice.
Chiao YA · eLife · 2020
Animal study (in vivo) · mouse · 8 results
- A mitochondrial permeability transition pore inhibitor improves renal outcomes after revascularization in experimental atherosclerotic renal artery stenosis.
Eirin A · Hypertension (Dallas, Tex. : 1979) · 2012
Animal study (in vivo) · pig · 9 results
- Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy.
Hou Y · American journal of physiology. Renal physiology · 2016
Animal study (in vivo) · mouse · 29 results
- Mitochondrial protection restores renal function in swine atherosclerotic renovascular disease.
Eirin A · Cardiovascular research · 2014
Animal study (in vivo) · pig · 9 results
- The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age.
Sweetwyne MT · Kidney international · 2017
Animal study (in vivo) · mouse · 9 results
- Mitochondrial oxidative damage reprograms lipid metabolism of renal tubular epithelial cells in the diabetic kidney.
Hou Y · Cellular and molecular life sciences : CMLS · 2024
Animal study (in vivo) · 5 results
- Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte.
Zhang H · eLife · 2020
Animal study (in vivo) · mouse and rat · 5 results
- Novel cardiolipin therapeutic protects endothelial mitochondria during renal ischemia and mitigates microvascular rarefaction, inflammation, and fibrosis.
Liu S · American journal of physiology. Renal physiology · 2014
Animal study (in vivo) · rat · 7 results
- Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia.
Brown DA · Journal of cardiovascular pharmacology and therapeutics · 2014
Animal study (in vivo) · rabbit · 7 results
- Mitochondria-Targeted Peptide Reverses Mitochondrial Dysfunction and Cognitive Deficits in Sepsis-Associated Encephalopathy.
Wu J · Molecular neurobiology · 2015
Animal study (in vivo) · mouse · 6 results
- Crosstalk between autophagy and oxidative stress regulates proteolysis in the diaphragm during mechanical ventilation.
Smuder AJ · Free radical biology & medicine · 2018
Animal study (in vivo) · rat · 2 results
- Mitochondrial permeability transition in the diabetic heart: contributions of thiol redox state and mitochondrial calcium to augmented reperfusion injury.
Sloan RC · Journal of molecular and cellular cardiology · 2012
Animal study (in vivo) · rat · 2 results
- The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats.
Allen ME · Communications biology · 2020
Animal study (in vivo) · rat · 6 results
- Mitochondria targeted peptide SS-31 prevent on cisplatin-induced acute kidney injury via regulating mitochondrial ROS-NLRP3 pathway.
Yang SK · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020
Animal study (in vivo) · mouse · 10 results
- Abnormalities of Mitochondrial Dynamics in the Failing Heart: Normalization Following Long-Term Therapy with Elamipretide.
Sabbah HN · Cardiovascular drugs and therapy · 2018
Animal study (in vivo) · dog · 7 results
- Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer's disease.
Calvo-Rodriguez M · Molecular neurodegeneration · 2024
Animal study (in vivo) · mouse · 3 results
- Mitochondrial targeting with antioxidant peptide SS-31 prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function.
Thomas DA · Journal of the American Society of Nephrology : JASN · 2007
Animal study (in vivo) · mouse · 7 results
- SS-31 Provides Neuroprotection by Reversing Mitochondrial Dysfunction after Traumatic Brain Injury.
Zhu Y · Oxidative medicine and cellular longevity · 2018
Animal study (in vivo) · mouse · 12 results
- Doxorubicin-induced oxidative stress differentially regulates proteolytic signaling in cardiac and skeletal muscle.
Montalvo RN · American journal of physiology. Regulatory, integrative and comparative physiology · 2020
Animal study (in vivo) · 8 results
- The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging.
Sanchez-Contreras M · eLife · 2023
Animal study (in vivo) · mouse · 2 results
- A novel cell-permeable antioxidant peptide decreases renal tubular apoptosis and damage in unilateral ureteral obstruction.
Mizuguchi Y · American journal of physiology. Renal physiology · 2008
Animal study (in vivo) · 4 results
- Combined Therapy with SS31 and Mitochondria Mitigates Myocardial Ischemia-Reperfusion Injury in Rats.
Lee FY · International journal of molecular sciences · 2018
Animal study (in vivo) · rat · 18 results
- Restoration of Mitochondrial Cardiolipin Attenuates Cardiac Damage in Swine Renovascular Hypertension.
Eirin A · Journal of the American Heart Association · 2016
Animal study (in vivo) · pig · 11 results
- SS-31 and NMN: Two paths to improve metabolism and function in aged hearts.
Whitson JA · Aging cell · 2020
Animal study (in vivo) · mouse · 8 results
- BDNF pathway is involved in the protective effects of SS-31 on isoflurane-induced cognitive deficits in aging mice.
Wu J · Behavioural brain research · 2016
Animal study (in vivo) · mouse · 3 results
- A mitochondrial therapeutic reverses visual decline in mouse models of diabetes.
Alam NM · Disease models & mechanisms · 2015
Animal study (in vivo) · mouse · 3 results
- Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heart.
Shi J · Life sciences · 2015
Animal study (in vivo) · rat · 8 results
- Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease.
Miyamoto S · The Journal of biological chemistry · 2020
Animal study (in vivo) · mouse · 6 results
- SS31 Ameliorates Sepsis-Induced Heart Injury by Inhibiting Oxidative Stress and Inflammation.
Liu Y · Inflammation · 2019
Animal study (in vivo) · mouse · 16 results
- Targeting Mitochondria by SS-31 Ameliorates the Whole Body Energy Status in Cancer- and Chemotherapy-Induced Cachexia.
Ballarò R · Cancers · 2021
Animal study (in vivo) · mouse · 9 results
- Characterization of acute and chronic neuropathies induced by oxaliplatin in mice and differential effects of a novel mitochondria-targeted antioxidant on the neuropathies.
Toyama S · Anesthesiology · 2014
Animal study (in vivo) · mouse · 6 results
- Mitochondrial targeted peptides attenuate residual myocardial damage after reversal of experimental renovascular hypertension.
Eirin A · Journal of hypertension · 2014
Animal study (in vivo) · pig · 6 results
- SS-31 Protects Liver from Ischemia-Reperfusion Injury via Modulating Macrophage Polarization.
Shang L · Oxidative medicine and cellular longevity · 2021
Animal study (in vivo) · 9 results
- The antioxidant peptide SS31 prevents oxidative stress, downregulates CD36 and improves renal function in diabetic nephropathy.
Hou Y · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018
Animal study (in vivo) · mouse · 16 results
- Role of mitochondrial dysfunction in renal fibrosis promoted by hypochlorite-modified albumin in a remnant kidney model and protective effects of antioxidant peptide SS-31.
Zhao H · European journal of pharmacology · 2017
Animal study (in vivo) · rat · 7 results
- A Mitochondrion-Targeted Antioxidant Ameliorates Isoflurane-Induced Cognitive Deficits in Aging Mice.
Wu J · PloS one · 2015
Animal study (in vivo) · mouse · 10 results
- The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT).
Pharaoh G · GeroScience · 2023
Animal study (in vivo) · 6 results