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Study · Animal study (in vivo) · pig · 2016

11 results

Restoration of Mitochondrial Cardiolipin Attenuates Cardiac Damage in Swine Renovascular Hypertension.

Eirin A, Ebrahimi B, Kwon SH, Fiala JA, Williams BJ, Woollard JR, He Q, Gupta RC, Sabbah HN, Prakash YS, Textor SC, Lerman A, Lerman LO

Journal of the American Heart Association31 May 2016Cited by 58 (Europe PMC)

PMID27247333 (opens in a new tab)PMCIDPMC4937260 (opens in a new tab)DOI10.1161/jaha.115.003118 (opens in a new tab)PepBankPUB-27247333
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In pigs with hypercholesterolemic renovascular hypertension, 4 weeks of Bendavia restored cardiac cardiolipin content.

    In plain wordsIn pigs with high blood pressure from kidney artery narrowing, Bendavia restored a key mitochondrial lipid in the heart.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseCardiac cardiolipin content
    Study

    pign: not reported in source

    Swine with hypercholesterolemic renovascular hypertension (HC-RVH)
    Comparator
    Vehicle
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    0.1 mg/kg · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Chronic mitoprotection in vivo restored cardiolipin content
    1 context sentence
    Summary · context
    After 12 weeks of hypercholesterolemic (HC)-RVH or control (n=14 each), pigs were treated for another 4 weeks with vehicle or with the mitochondrial-targeted peptide (MTP), Bendavia (0.1 mg/kg subcutaneously, 5 days/week), which stabilizes mitochondrial inner-membrane cardiolipin (n=7 each).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In pigs with hypercholesterolemic renovascular hypertension, Bendavia restored cardiac mitochondrial biogenesis.

    In plain wordsIn pigs with high blood pressure from kidney artery narrowing, Bendavia restored the making of new mitochondria in the heart.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseCardiac mitochondrial biogenesis
    Study

    pign: not reported in source

    Swine with hypercholesterolemic renovascular hypertension (HC-RVH)
    Comparator
    Vehicle
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    0.1 mg/kg · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Chronic mitoprotection in vivo restored cardiolipin content and mitochondrial biogenesis.
    1 context sentence
    Summary · context
    After 12 weeks of hypercholesterolemic (HC)-RVH or control (n=14 each), pigs were treated for another 4 weeks with vehicle or with the mitochondrial-targeted peptide (MTP), Bendavia (0.1 mg/kg subcutaneously, 5 days/week), which stabilizes mitochondrial inner-membrane cardiolipin (n=7 each).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In pigs with hypercholesterolemic renovascular hypertension, thapsigargin-sensitive SR Ca(2+)-ATPase activity, which declined in untreated disease, normalized with Bendavia.

    In plain wordsIn pigs with high blood pressure from kidney artery narrowing, Bendavia returned a heart calcium-pump activity to normal.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseSarcoplasmic reticulum Ca2+-ATPase activity
    Study

    pign: not reported in source

    Swine with hypercholesterolemic renovascular hypertension (HC-RVH)
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.1 mg/kg · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Thapsigargin-sensitive sarcoplasmic reticulum Ca(2+)-ATPase activity that declined in HC-RVH normalized in MTP-treated pigs.
    1 context sentence
    Summary · context
    After 12 weeks of hypercholesterolemic (HC)-RVH or control (n=14 each), pigs were treated for another 4 weeks with vehicle or with the mitochondrial-targeted peptide (MTP), Bendavia (0.1 mg/kg subcutaneously, 5 days/week), which stabilizes mitochondrial inner-membrane cardiolipin (n=7 each).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with hypercholesterolemic renovascular hypertension, Bendavia improved left ventricular relaxation (E/A ratio).

    In plain wordsIn pigs with high blood pressure from kidney artery narrowing, Bendavia improved how well the heart relaxed.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseLeft ventricular relaxation (E/A ratio)
    Study

    pign: not reported in source

    Swine with hypercholesterolemic renovascular hypertension (HC-RVH)
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.1 mg/kg · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Mitoprotection also improved LV relaxation (E/A ratio)
    1 context sentence
    Summary · context
    After 12 weeks of hypercholesterolemic (HC)-RVH or control (n=14 each), pigs were treated for another 4 weeks with vehicle or with the mitochondrial-targeted peptide (MTP), Bendavia (0.1 mg/kg subcutaneously, 5 days/week), which stabilizes mitochondrial inner-membrane cardiolipin (n=7 each).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with hypercholesterolemic renovascular hypertension, Bendavia ameliorated cardiac hypertrophy.

    In plain wordsIn pigs with high blood pressure from kidney artery narrowing, Bendavia reduced thickening of the heart muscle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCardiac hypertrophy
    Study

    pign: not reported in source

    Swine with hypercholesterolemic renovascular hypertension (HC-RVH)
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.1 mg/kg · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Mitoprotection also improved LV relaxation (E/A ratio) and ameliorated cardiac hypertrophy
    1 context sentence
    Summary · context
    After 12 weeks of hypercholesterolemic (HC)-RVH or control (n=14 each), pigs were treated for another 4 weeks with vehicle or with the mitochondrial-targeted peptide (MTP), Bendavia (0.1 mg/kg subcutaneously, 5 days/week), which stabilizes mitochondrial inner-membrane cardiolipin (n=7 each).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with hypercholesterolemic renovascular hypertension, Bendavia did not affect blood pressure.

    In plain wordsIn pigs with high blood pressure from kidney artery narrowing, Bendavia did not change blood pressure.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeBlood pressure
    Study

    pign: not reported in source

    Swine with hypercholesterolemic renovascular hypertension (HC-RVH)
    Comparator
    Vehicle
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    0.1 mg/kg · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Mitoprotection also improved LV relaxation (E/A ratio) and ameliorated cardiac hypertrophy, without affecting blood pressure or systolic function.
    1 context sentence
    Summary · context
    After 12 weeks of hypercholesterolemic (HC)-RVH or control (n=14 each), pigs were treated for another 4 weeks with vehicle or with the mitochondrial-targeted peptide (MTP), Bendavia (0.1 mg/kg subcutaneously, 5 days/week), which stabilizes mitochondrial inner-membrane cardiolipin (n=7 each).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with hypercholesterolemic renovascular hypertension, Bendavia did not affect systolic function.

    In plain wordsIn pigs with high blood pressure from kidney artery narrowing, Bendavia did not change the heart's pumping strength.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeSystolic function
    Study

    pign: not reported in source

    Swine with hypercholesterolemic renovascular hypertension (HC-RVH)
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.1 mg/kg · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Mitoprotection also improved LV relaxation (E/A ratio) and ameliorated cardiac hypertrophy, without affecting blood pressure or systolic function.
    1 context sentence
    Summary · context
    After 12 weeks of hypercholesterolemic (HC)-RVH or control (n=14 each), pigs were treated for another 4 weeks with vehicle or with the mitochondrial-targeted peptide (MTP), Bendavia (0.1 mg/kg subcutaneously, 5 days/week), which stabilizes mitochondrial inner-membrane cardiolipin (n=7 each).
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with hypercholesterolemic renovascular hypertension, myocardial remodeling improved only in Bendavia-treated pigs.

    In plain wordsIn pigs with high blood pressure from kidney artery narrowing, heart muscle remodeling improved only with Bendavia.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMyocardial remodeling
    Study

    pign: not reported in source

    Swine with hypercholesterolemic renovascular hypertension (HC-RVH)
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.1 mg/kg · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Myocardial remodeling and coronary endothelial function improved only in MTP-treated pigs.
    1 context sentence
    Summary · context
    After 12 weeks of hypercholesterolemic (HC)-RVH or control (n=14 each), pigs were treated for another 4 weeks with vehicle or with the mitochondrial-targeted peptide (MTP), Bendavia (0.1 mg/kg subcutaneously, 5 days/week), which stabilizes mitochondrial inner-membrane cardiolipin (n=7 each).
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with hypercholesterolemic renovascular hypertension, coronary endothelial function improved only in Bendavia-treated pigs.

    In plain wordsIn pigs with high blood pressure from kidney artery narrowing, heart artery lining function improved only with Bendavia.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseCoronary endothelial function
    Study

    pign: not reported in source

    Swine with hypercholesterolemic renovascular hypertension (HC-RVH)
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.1 mg/kg · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Myocardial remodeling and coronary endothelial function improved only in MTP-treated pigs.
    1 context sentence
    Summary · context
    After 12 weeks of hypercholesterolemic (HC)-RVH or control (n=14 each), pigs were treated for another 4 weeks with vehicle or with the mitochondrial-targeted peptide (MTP), Bendavia (0.1 mg/kg subcutaneously, 5 days/week), which stabilizes mitochondrial inner-membrane cardiolipin (n=7 each).
  10. 10LabIn vitro (cells)Mechanism

    In rat cardiomyocytes exposed to tBHP, the mitochondrial-targeted peptide attenuated the fall in cardiolipin content.

    In plain wordsIn rat heart cells under chemical stress, the peptide limited the loss of a key mitochondrial lipid.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseCardiolipin content in cardiomyocytes exposed to tBHP
    Study

    ratn: not reported in source

    Rat cardiomyocytes incubated with tert-butyl hydroperoxide (tBHP)
    Comparator
    Untreated cardiomyocytes
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In tBHP-treated cardiomyocytes, mitochondrial targeting attenuated a fall in cardiolipin content and bioenergetics.
    1 context sentence
    Summary · context
    Additionally, mitochondrial cardiolipin content, oxidative stress, and bioenergetics were assessed in rat cardiomyocytes incubated with tert-butyl hydroperoxide (tBHP) untreated or treated with MTP.
  11. 11LabIn vitro (cells)Mechanism

    In rat cardiomyocytes exposed to tBHP, the mitochondrial-targeted peptide attenuated the fall in bioenergetics.

    In plain wordsIn rat heart cells under chemical stress, the peptide limited the drop in cell energy production.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseBioenergetics in cardiomyocytes exposed to tBHP
    Study

    ratn: not reported in source

    Rat cardiomyocytes incubated with tert-butyl hydroperoxide (tBHP)
    Comparator
    Untreated cardiomyocytes
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In tBHP-treated cardiomyocytes, mitochondrial targeting attenuated a fall in cardiolipin content and bioenergetics.
    1 context sentence
    Summary · context
    Additionally, mitochondrial cardiolipin content, oxidative stress, and bioenergetics were assessed in rat cardiomyocytes incubated with tert-butyl hydroperoxide (tBHP) untreated or treated with MTP.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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